ID H0VIA4_CAVPO Unreviewed; 436 AA.
AC H0VIA4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Keratin 40 {ECO:0000313|Ensembl:ENSCPOP00000009918.3};
GN Name=KRT40 {ECO:0000313|Ensembl:ENSCPOP00000009918.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009918.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009918.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009918.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AAKN02042401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VIA4; -.
DR STRING; 10141.ENSCPOP00000009918; -.
DR Ensembl; ENSCPOT00000011138.3; ENSCPOP00000009918.3; ENSCPOG00000011037.4.
DR VEuPathDB; HostDB:ENSCPOG00000011037; -.
DR eggNOG; ENOG502SHG0; Eukaryota.
DR GeneTree; ENSGT00940000161968; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; H0VIA4; -.
DR OMA; CAASRCQ; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011037; Expressed in zone of skin.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF90; KERATIN, TYPE I CYTOSKELETAL 40; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 89..400
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 93..163
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 258..399
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 436 AA; 48141 MW; 04A617308ACB6179 CRC64;
MTAAGSLVRG SPESCARDVG CAPASTCSPA VTRLSSAGPV SGCQASSLLP GTHLSPGCPA
PCYLAVGCDG GCLVENGPWC EDGAFNSHEK ETMQFLNDRL ANYLEKVRCL EEANAELESK
IQGQCEPDAL VVCPDYQCYF DTIEDLQQKI LCTKAENSRL AVQLDNRKLA VDDFRSRYDS
ELSLRQLLEN DISGLRGILG ELSLCRSDLE AQVESLKDDL LCLKKSHQEE VSVLRAQLGD
RLNVELDMAP TVDLNGALEE MRRQYETVLA NNRKEAEEWF SAQAEELSQQ QLSSAEQLQG
CQVEILELKR TANTLEIELQ AQQNLTDSLE CTMAETEAQY STQLAQMQGL IDNVETQLEE
IRCDLERQNQ EYQVLLDTKA RLEQEIATYR RLLDREDSRQ VPQLASSPCS VVMPSSGNPC
EPGSAYILCT VENCCA
//
