ID H0VIB3_CAVPO Unreviewed; 422 AA.
AC H0VIB3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Interleukin 13 receptor subunit alpha 1 {ECO:0000313|Ensembl:ENSCPOP00000009932.2};
GN Name=IL13RA1 {ECO:0000313|Ensembl:ENSCPOP00000009932.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009932.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009932.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009932.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AAKN02039608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003467644.1; XM_003467596.2.
DR AlphaFoldDB; H0VIB3; -.
DR STRING; 10141.ENSCPOP00000009932; -.
DR Ensembl; ENSCPOT00000011152.3; ENSCPOP00000009932.2; ENSCPOG00000011050.4.
DR GeneID; 100731095; -.
DR KEGG; cpoc:100731095; -.
DR CTD; 3597; -.
DR VEuPathDB; HostDB:ENSCPOG00000011050; -.
DR eggNOG; ENOG502RYXH; Eukaryota.
DR GeneTree; ENSGT00940000160896; -.
DR HOGENOM; CLU_039945_1_0_1; -.
DR InParanoid; H0VIB3; -.
DR OMA; YDICEKQ; -.
DR OrthoDB; 5305678at2759; -.
DR TreeFam; TF331549; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011050; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040566; Il13Ra_Ig.
DR InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF89; INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1; 1.
DR Pfam; PF18001; Il13Ra_Ig; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..422
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003542017"
FT TRANSMEM 339..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 222..336
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 422 AA; 48016 MW; 2FA2AA05570B83E1 CRC64;
MELPARVCGL WALLLGAGVG AAPPETQPPV TNLSVSVENL CTVIWTWNPP EGASPNCSLR
YFSHFDDQQE KKIAPETHRS KEVPLNEKIC LQVGSQCSTN ESEKRSILLE KCISPLEGDP
ESAVTELQCI WHNLRLMNCS WLPGKNSSPD TNYTLFYWHS SLGKILQCEN IYKDGQYIGC
SFDLSKVKTS SFEQHSVQIM VKDNAGKIRP SFHIVPLTSR VKPDPPHIKN LLFKEGTLYV
QWKNPPNFES RCLSYEVEVN KSQTEIHRLF STDEDGCQNA VFERNMNDTT CFMVPGVLPD
TFYTVRIRVK TNKLCYEDDK LWSNWSQVMG IGKKPNSTFY MTMLLIIPVI IAGAIIVLLL
YLKRLKIIIF PPIPDPGKIF KEMFGDQNDD TLHWKKYDIC EKQSKEDTDS VVLIENLKKA
SQ
//
