ID H0VIN5_CAVPO Unreviewed; 364 AA.
AC H0VIN5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Fetuin B {ECO:0000313|Ensembl:ENSCPOP00000010077.3};
GN Name=FETUB {ECO:0000313|Ensembl:ENSCPOP00000010077.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010077.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000010077.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010077.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02012343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VIN5; -.
DR STRING; 10141.ENSCPOP00000010077; -.
DR Ensembl; ENSCPOT00000011313.3; ENSCPOP00000010077.3; ENSCPOG00000011207.4.
DR VEuPathDB; HostDB:ENSCPOG00000011207; -.
DR GeneTree; ENSGT00950000182930; -.
DR HOGENOM; CLU_044085_1_0_1; -.
DR InParanoid; H0VIN5; -.
DR OMA; TIRYHIF; -.
DR TreeFam; TF333729; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011207; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 2.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR025764; Cystatin_Fetuin_B.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR001363; Prot_inh_fetuin_CS.
DR PANTHER; PTHR13814; FETUIN; 1.
DR PANTHER; PTHR13814:SF10; FETUIN-B; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 2.
DR PROSITE; PS51530; CYSTATIN_FETUIN_B; 1.
DR PROSITE; PS01255; FETUIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..364
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013356839"
FT DOMAIN 146..252
FT /note="Cystatin fetuin-B-type"
FT /evidence="ECO:0000259|PROSITE:PS51530"
FT REGION 258..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 40173 MW; FF2714741CE0CCA9 CRC64;
MDLRWSLVLC ALAQVTCCGA RSVPLQPLSF PNPLPRGCND SDVLFFSGLA LKHINADQQD
GYVLGLNRVH DAWEHIQVSR GSLFYLTLDV LETSCHVLSR KDWTDCGGRP LYESVIVCFV
AIDKIENRYF LKKLFSLISI VSRRKLLCPD CPFPSTTDFS DDGILKAATE TLAKYNNESA
SKQYSLDKVT RVSRQWVSGP AYYVEYLIRE SPCNKSQASS CPLQPSASAP VGFCHGSLIE
SLFKKYISVT CNIFKSQVQT PGSENSPENT APSSSPAERK PRGSIQHLPA VDHEKPEDSQ
DKDQEIFPVQ LDLTTNPLGG HLDISSIFIG PQKEQLVVLP FPKAPRSAEC PGPARETSSL
VLPP
//
