ID H0VJ64_CAVPO Unreviewed; 785 AA.
AC H0VJ64;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN Name=CUL5 {ECO:0000313|Ensembl:ENSCPOP00000010281.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010281.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000010281.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010281.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AAKN02053832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VJ64; -.
DR Ensembl; ENSCPOT00000011542.3; ENSCPOP00000010281.3; ENSCPOG00000011436.4.
DR VEuPathDB; HostDB:ENSCPOG00000011436; -.
DR GeneTree; ENSGT00940000156648; -.
DR HOGENOM; CLU_004747_5_0_1; -.
DR TreeFam; TF105874; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011436; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 408..643
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 785 AA; 91467 MW; ADA24BA63BBAA895 CRC64;
MLCLSLSPTP NLLNKGSLQF EDKWDFMRPI VLKLLRQESV TKQQWFDLFS DVHAVCLWDD
KGPAKIHQAL KEDILEFIKQ AQARVLSHQD DTALLKAYIV EWRKFFTQCD ILPKPFCQLE
ITLMGKQGSN KKTNVEDSIV RKLMLDTWNE SIFSNIKNRL QDSAMKLVHA ERLGEAFDSQ
LVIGVRESYV NLCSNPEDKL QIYRDNFEKA YLDSTERFYR TQAPSYLQQN GVQNYMKYAD
AKLKEEEKRA LRYLETRREC NSVEALMECC VNALVTSFKE TILAECQGMI KRNETEKLHL
MFSLMDKVPN GIEPMLKDLE EHIISAGLAD MVAAAETITT DSEKYVEQLL TLFNRFSKLV
KEAFQDDPRF LTARDKAYKA VVNDATIFKL ELPLKQKGVG LKTQPESKCP ELLANYCDML
LRKTPLSKKL TSEEIEAKLK EVLLVLKYVQ NKDVFMRYHK AHLTRRLILD ISADSEIEEN
MVEWLREVGM PADYVNKLAR MFQDIKVSED LNQAFKEMHK NNKLALPADS VNIKILNAGA
WSRSSEKVFV SLPTELEDLI PEVEEFYKKN HSGRKLHWHH LMSNGIITFK NEVGQYDLEV
TTFQLAVLFA WNQRPREKIS FENLKLATEL PDAELRRTLW SLVAFPKLKR QVLLYEPQVS
SPKDFTEGTL FSVNQEFSLI KNAKVQKRGK INLIGRLQLT TERMREEENE GIVQLRILRT
QEAIIQIMKM RKKISNAQLQ TELVEILKNM FLPQKKMIKE QIEWLIEHKY IRRDESDINT
FIYMA
//
