GenomeNet

Database: UniProt
Entry: H0VK50_CAVPO
LinkDB: H0VK50_CAVPO
Original site: H0VK50_CAVPO 
ID   H0VK50_CAVPO            Unreviewed;      1356 AA.
AC   H0VK50;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   26-FEB-2020, entry version 56.
DE   SubName: Full=CASK interacting protein 1 {ECO:0000313|Ensembl:ENSCPOP00000010658};
GN   Name=CASKIN1 {ECO:0000313|Ensembl:ENSCPOP00000010658};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010658};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000010658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010658};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000010658}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010658};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAKN02007402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005007475.1; XM_005007418.2.
DR   Ensembl; ENSCPOT00000011963; ENSCPOP00000010658; ENSCPOG00000011848.
DR   GeneID; 100732339; -.
DR   CTD; 57524; -.
DR   eggNOG; KOG0507; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   GeneTree; ENSGT00940000158025; -.
DR   HOGENOM; CLU_003619_1_1_1; -.
DR   InParanoid; H0VK50; -.
DR   OrthoDB; 75723at2759; -.
DR   TreeFam; TF320582; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000011848; Expressed in brain and 1 other tissue.
DR   CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR   CDD; cd12062; SH3_Caskin1; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR027013; Caskin-1/2.
DR   InterPro; IPR032232; Caskin1-CID.
DR   InterPro; IPR035498; Caskin1/2_SAM_2.
DR   InterPro; IPR035495; Caskin1_SH3.
DR   InterPro; IPR032117; Caskin_C.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR24174:SF11; PTHR24174:SF11; 2.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF16632; Caskin-tail; 1.
DR   Pfam; PF16600; Caskin1-CID; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00454; SAM; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00752027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00752241};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192}.
FT   DOMAIN          41..289
FT                   /note="ANK_REP_REGION"
FT                   /evidence="ECO:0000259|PROSITE:PS50297"
FT   DOMAIN          281..347
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          474..534
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          349..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          420..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          940..967
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1001..1043
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1055..1298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1314..1342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..372
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..589
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..824
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1012..1027
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1070..1087
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1091..1106
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1113..1159
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1192..1210
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1212..1226
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1227..1241
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1248..1265
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1356 AA;  142720 MW;  45BE80809BCCDACC CRC64;
     MGKEQELVQA VKAEDVGTAQ RLLQRARPGK AKLLGSTKKI NVNFQDPDGF SALHHAALNG
     NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL VLKAGSAVNV PSDEGHIPLH
     LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT PLDLACEFGR VGVVQLLLSS NMCAALLEPR
     PSDTTDPNGT SPLHLAAKNG HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL
     LDSGINAQVR NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
     LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG SRVGSEPSTA
     QVGSSSGSSA PSEEIWVLRK PFAGGDRSGS LSSVAGGRSG GGHTLHAGSE GVKLLATVLS
     QKSVSESSPG DSPVKPPEGT TGAARSQPPV AHTGQVYVEQ PPKKLEPASE GKANLAVWLS
     MIGLAQYYKV LVDNGYENID FITDITWEDL QEIGITKLGH QKKLMLAVRK LAELQKAEYA
     KYEGGPLRRK APQSLEMMAI ESPPPPEPAP ADCQSPKMTT FQDSELSGEL QAAMTGPAEG
     GTAEKPSNHL PTPKATMRHE PSLGGRVRHM SSSQELLGEG PPGSGSPMSR SQEYLLDEGQ
     VPGTPPKEVR PSRHGHSVKR ASVPPVPGKP RQVLPPSGSH FTPPQTPTKA RPGSPQALTG
     PHGPSPVTAK VKPTPQLLPP TERPMSPRSL PQSPTHRGFA YVLPQPVEGD TGPATPGPVP
     QTMPVAVPTL CLPPEAEAEP GRPKKRAHSL NRYAASDSEP ERDELLVPAA AGPYATVQRR
     VGRSHSVRAP AGTDKNVNRS QSFAVRPRKK GPPPPPPKRS SSAMASANLV DEPAPDAETE
     DDRLGVRAQR RRASDLAGSV DTGSAGSVKS IAAMLELSSI GGGGRAARRP PEGHPTPHPA
     SPEPGRVATV LASVKHKEAI GPDGEVVNRR RTLSGPVTGL LATARQGPGE PTDHGHFVED
     GKARQRPQGP AKGETSVDGP PLARVEASAT LKRRIRAKQN QQENVKFILT ESDTVKRRPK
     AKEREAGSET LPSLSVYQNG TATVRRRPAS EQAGPPELPP PPPPAEPPPT DLAHLPPLPL
     PEGDARKPAK PPVSPKPVLT QPVPKIQGSP TPSSKKVPLP GPGSPEVKRA HGTPPPVSPK
     PPPPPTAPKP AKATTGLQSG STTPSPAPSP VRQPPAALAK PASTPPSLSA SPAKPPSPSA
     PALHVPAKPP RAAAAAAAGA PTVLDGASPG DSARQKLEET SACLAAALQA VEEKIRQEDR
     QGSRPSAAEE KSTGSILDDI GSMFDDLADQ LDAMLE
//
DBGET integrated database retrieval system