ID H0VKF8_CAVPO Unreviewed; 140 AA.
AC H0VKF8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Transmembrane protein 234 {ECO:0000313|Ensembl:ENSCPOP00000010786.3};
GN Name=TMEM234 {ECO:0000313|Ensembl:ENSCPOP00000010786.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010786.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000010786.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010786.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM234 family.
CC {ECO:0000256|ARBA:ARBA00005977}.
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DR EMBL; AAKN02028598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003471132.1; XM_003471084.3.
DR AlphaFoldDB; H0VKF8; -.
DR STRING; 10141.ENSCPOP00000010786; -.
DR Ensembl; ENSCPOT00000012104.3; ENSCPOP00000010786.3; ENSCPOG00000011988.4.
DR GeneID; 100729647; -.
DR KEGG; cpoc:100729647; -.
DR CTD; 56063; -.
DR VEuPathDB; HostDB:ENSCPOG00000011988; -.
DR eggNOG; KOG4831; Eukaryota.
DR GeneTree; ENSGT00940000162781; -.
DR HOGENOM; CLU_108086_2_0_1; -.
DR InParanoid; H0VKF8; -.
DR OMA; WGGTNPL; -.
DR OrthoDB; 253393at2759; -.
DR TreeFam; TF300180; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011988; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018908; TMEM234.
DR PANTHER; PTHR28668; TRANSMEMBRANE PROTEIN 234; 1.
DR PANTHER; PTHR28668:SF1; TRANSMEMBRANE PROTEIN 234; 1.
DR Pfam; PF10639; TMEM234; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..140
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011448694"
FT TRANSMEM 57..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 140 AA; 14961 MW; 1A8FDD8DE60CB62C CRC64;
MAASLGQVLA LVLVAALWGG TQPLLKRASA GLQEVQERNW ARQLLQEMKT LFLNTEYLMP
FLLNQCGSLL YYLTLASTDL TLAVPICNSL AIVFTLIVGK LLGEDVGGKQ AAAGMVLTVT
GITLCIMSSV NKTQGQPSTF
//
