ID H0VKR4_CAVPO Unreviewed; 705 AA.
AC H0VKR4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=PWWP domain containing 3B {ECO:0000313|Ensembl:ENSCPOP00000010914.3};
GN Name=PWWP3B {ECO:0000313|Ensembl:ENSCPOP00000010914.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010914.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000010914.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010914.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PWWP3A family.
CC {ECO:0000256|ARBA:ARBA00008188}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02040878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005002669.1; XM_005002612.2.
DR RefSeq; XP_005002670.1; XM_005002613.2.
DR RefSeq; XP_013005462.1; XM_013150008.1.
DR AlphaFoldDB; H0VKR4; -.
DR STRING; 10141.ENSCPOP00000010914; -.
DR Ensembl; ENSCPOT00000012255.3; ENSCPOP00000010914.3; ENSCPOG00000012139.4.
DR GeneID; 100715873; -.
DR KEGG; cpoc:100715873; -.
DR CTD; 139221; -.
DR VEuPathDB; HostDB:ENSCPOG00000012139; -.
DR eggNOG; ENOG502QPRU; Eukaryota.
DR GeneTree; ENSGT00390000001700; -.
DR HOGENOM; CLU_388271_0_0_1; -.
DR InParanoid; H0VKR4; -.
DR OMA; KYRKHEG; -.
DR OrthoDB; 5403864at2759; -.
DR TreeFam; TF328774; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012139; Expressed in pituitary gland and 7 other cell types or tissues.
DR CDD; cd06080; PWWP_MUM1-like; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 6.10.300.20; -; 1.
DR InterPro; IPR035504; MUM1-like_PWWP.
DR InterPro; IPR040263; PWP3A_3B_4.
DR InterPro; IPR048795; PWP3A_3B_4_C.
DR InterPro; IPR048765; PWP3A_3B_4_N.
DR PANTHER; PTHR31333; PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR31333:SF3; PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3B; 1.
DR Pfam; PF20884; MUM1-like_PWWP; 1.
DR Pfam; PF20886; PWP3A-B_C; 1.
DR Pfam; PF20887; PWP3A-B_N; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 5..98
FT /note="PWWP"
FT /evidence="ECO:0000259|Pfam:PF20887"
FT DOMAIN 405..484
FT /note="MUM1-like PWWP"
FT /evidence="ECO:0000259|Pfam:PF20884"
FT DOMAIN 557..697
FT /note="PWWP"
FT /evidence="ECO:0000259|Pfam:PF20886"
FT REGION 171..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 80089 MW; 8C3E3A247D896CA3 CRC64;
MNPEYVLCNW KDQVWPAKVL SRSKTSSRGK RKSTSSLEVQ ILSLDETVKV KSTETKTLNK
SEIEAIVSSL AVQSEVSDVH REDTPYGRAL KEALHILDKR AILSQASITD EGETSIHTEN
VGQELSDIPP CKRYQKHEEC FEENEDQTPP LLSSESDVSL TDDEVEVHPT VDTVQNEEEI
QSPENFTSYQ ASPLLSEDND KKEDKIKIST FMSADSTVKG ESELVEDEKC VASSSSKDEK
CVQSSLSKDE NCVPSSSSDI LTASKGLKED TQDTCPDILP VSSECPTFSE TIEDPEEGPS
NPNPRLDVSQ GQSPVESEVG AETSSPSCSW QNQAAFSSTR PVLDYSLLVN SERYLQRLDI
EEFEEDALAS DKSLRLNAAS LSALDDDEED EELPRFIFQY EPRSFEAGMI VWFKYKKYPF
WPAVVKSIRR KEKKASVLFV EANMNPEKKG IRVPLRSLKK FDCKEKQELV DKAREEYNES
IDWCISLICD YRVRIGCGSF SGSFLEYYAA DISCPMRKAI QRDTFRNMFP KLPNEDTVEQ
MVVTSQSKKR SFQKILPDRM KAARDRANRN LVDYIVNAKG TDSHLVAILK RRKESRWLKS
FLHQSTIMPC IETYIEDEDQ LDEIVRYLQV LYDHIDKKLQ TLIRDDKINF ILQVLLPEAV
ICSISAVDGL DYETAEAKYL KGPSLGCRER ELFDAKILVG KRRKR
//
