ID H0VLJ3_CAVPO Unreviewed; 975 AA.
AC H0VLJ3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=ELKS/RAB6-interacting/CAST family member 2 {ECO:0000313|Ensembl:ENSCPOP00000011232.3};
GN Name=ERC2 {ECO:0000313|Ensembl:ENSCPOP00000011232.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011232.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011232.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011232.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AAKN02001338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VLJ3; -.
DR STRING; 10141.ENSCPOP00000011232; -.
DR Ensembl; ENSCPOT00000012603.3; ENSCPOP00000011232.3; ENSCPOG00000012484.4.
DR VEuPathDB; HostDB:ENSCPOG00000012484; -.
DR GeneTree; ENSGT00650000093320; -.
DR HOGENOM; CLU_009304_0_0_1; -.
DR InParanoid; H0VLJ3; -.
DR OMA; EEILEMX; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012484; Expressed in frontal cortex and 4 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0098831; C:presynaptic active zone cytoplasmic component; IEA:Ensembl.
DR GO; GO:0098882; F:structural constituent of presynaptic active zone; IEA:Ensembl.
DR GO; GO:0150037; P:regulation of calcium-dependent activation of synaptic vesicle fusion; IEA:Ensembl.
DR GO; GO:0099509; P:regulation of presynaptic cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0016082; P:synaptic vesicle priming; IEA:Ensembl.
DR Gene3D; 1.10.287.1490; -; 1.
DR InterPro; IPR019323; ELKS/CAST.
DR PANTHER; PTHR18861; ELKS/RAB6-INTERACTING/CAST PROTEIN; 1.
DR PANTHER; PTHR18861:SF3; ERC PROTEIN 2; 1.
DR Pfam; PF10174; Cast; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 145..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 231..282
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 338..925
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..957
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 112842 MW; FE83B1CCB6D4365F CRC64;
YGSARAITNL EGSPSRSPRL PRSPRLGHRR TSSGGGGGAG KTLSMENIQS LNAAYATSGP
MYLSDHEGVA STTYPKGTMT LGRATNRAVY GGRVTAMGSS PNIASAGLSH TDVLSYTDQH
GLTSSSHHHH HQVPSMLRQV RDSTMLDLQA QLKELQREND LLRKELDIKD SKLGSSMNSI
KTFWSPELKK ERVLRKEEAA RMSVLKEQMR VSHEENQLLE ARRTKHLQLT IQALQDELRT
QRDLNHLLQQ ESGNRGAEHF TIELTEENFR RLQAEHDRQA KELFLLRKTL EEMELRIETQ
KQTLNARDES IKKLLEMLQS KGLPSKSLED DNERTRRMAE AESQVSHLEV ILDQKEKENI
HLREELHRRS QLQQEPAKTK ALQTVIEMKD TKIASLERNI RDLEDEIQML KANGALNTED
REEEIKQIEV YKSHSKFMKT KIDQLKQELS KKESELLALQ TKLETLSNQN SDCKQHIEVL
KESLTAKEQR AAILQTEVDA LRLRLEEKES FLNKKTKQLQ DLTEEKGTLA GEIRDLKDML
EVKERKINVL QKKIENLQEQ LRDKDKQLTN LKDRVKSLQT DSSNTDTALA TLEEALSEKE
RIIERLKEQR ERDDRERLEE IESFRKENKD LKEKVNALQA ELTEKESSLI DLKEHASSLA
SAGLKRDSKL KSLEIAIEQK KEECSKLEAQ LKKQAEQLFN QMYNPAHNIE DDSRMNPEFA
DRLKQLDKEA SYYRDECNKA QAEVDRLLEI LKEVENEKND KDKKIAELES LTLRHMKDQN
KKVANLKHNQ QLEKKKNAQL LEEVRRREDS MADNSQHLQI EELMNALEKT RQELDATKAR
LASTQQSLAE KEAHLANLRV ERRKQLEEIL EMKQEALLAA ISEKDANIAL LELSASKKKK
TQEEVMALKR EKDRLVHQLK QQTQNRMKLM ADNYDEDHHH YHHHHHHHHH RSPGRSQHSN
HRPSPDQDDE EGIWA
//
