ID H0VLN0_CAVPO Unreviewed; 1389 AA.
AC H0VLN0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=YEATS domain containing 2 {ECO:0000313|Ensembl:ENSCPOP00000011275.3};
GN Name=YEATS2 {ECO:0000313|Ensembl:ENSCPOP00000011275.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011275.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011275.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011275.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00376}.
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DR EMBL; AAKN02012293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000011275; -.
DR Ensembl; ENSCPOT00000012651.3; ENSCPOP00000011275.3; ENSCPOG00000012531.4.
DR VEuPathDB; HostDB:ENSCPOG00000012531; -.
DR eggNOG; KOG3149; Eukaryota.
DR GeneTree; ENSGT00940000156789; -.
DR HOGENOM; CLU_258270_0_0_1; -.
DR InParanoid; H0VLN0; -.
DR OMA; XVVDVEL; -.
DR TreeFam; TF314586; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012531; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0140672; C:ATAC complex; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0140566; F:histone reader activity; IEA:Ensembl.
DR GO; GO:0140030; F:modification-dependent protein binding; IEA:Ensembl.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0051302; P:regulation of cell division; IEA:Ensembl.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:Ensembl.
DR GO; GO:0090043; P:regulation of tubulin deacetylation; IEA:Ensembl.
DR CDD; cd16907; YEATS_YEATS2_like; 1.
DR Gene3D; 2.60.40.1970; YEATS domain; 1.
DR InterPro; IPR038704; YEAST_sf.
DR InterPro; IPR005033; YEATS.
DR PANTHER; PTHR23195; YEATS DOMAIN; 1.
DR PANTHER; PTHR23195:SF7; YEATS DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF03366; YEATS; 1.
DR PROSITE; PS51037; YEATS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00376}; Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 117..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 147496 MW; 23A0CAB73F033024 CRC64;
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF ALEMKNKEHE
IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGAK TCDTMVFNHP AIKKFLESPS
RSSSPTNQRS ETPSANHSES DSLSQHNDFL SDKDNNSTMD MEERLSNSLE QRPRRNAGRD
TSSVTGSRKT EQRDTDLTGD ETSRLFVKKT IVVGNVSKYI PPDKREENDQ STHKWMVYVR
GSRREPSINH FVKKVWFFLH PSYKPNDLVE VREPPFHLTR RGWGEFPVRV QVHFKDSQNK
RIDIIHNLKL DRTYTGLQTL GAETVVDVEL HRHSLGEDCV YPQSSESDVS DAPPSLPLTI
PAPVKASSPI KQSLEPGPDA AGEKGFPAST EAERHTTFYS LPSSLERTPT KVTASQKVTF
CSHGNSAFQP IASSCKIVPQ SQIPNPESPG KSFQPITMSC KIVSGSPIST PSPSPLPRTP
TSTPVHVKQG TASSVINNPY VIVDKPGQVV GASTASTGSP TNKLSTASQV SQGTGSPVPK
IHGSSFVTSA VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH
VPTTGAAGQS PLPQYVTVKG GHMITVSPQK QVITTAEGTA QSPKIQPSKV VGVPVGAALP
SSVKQAVAIG GGQILVAKAS SSVAKAVGPK QVMTQGVAKA IVSGGGGTIV AQPVQTLSKA
QVAASGPQKS GPQGSVMATL QLPATNLANL ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG
AILRATNSAS LQSSSATASA GGAGGGGGGG GSSGGAAGGT QSTTGLGGIS QHLTYTSYIL
KQTPQGTFLV GQPSPQTSGK QLAAGSVVQG TLGVGSSSAQ GQQTLKVISG QKTTLFTQAA
SGGQASLMKI SDSTLKSVPA TSQLSKPGTT MVRVAGGVIT TAAPPTMALS ANGPAQQSEG
TVPSSSAAAG SAMKTVGQTQ VTASLVSAPS PVSGKATMSG LLKIHSSQSS PQQAVLTIPS
QLKPLSVNTS GGVQTILMPV NKVVQSFSAS KSPTILPVAS PAPAVPSSAP TAVTKVKTEP
EAPAPSCLSQ EVQTAVKTEE SSELGSYVIK IEHLETIQQL LTAVVKKIPL ITAKSEDTSC
FSAKSVEQYY SWNIGKRRAA EWQRAMTMRK VLQEILEKNP RFHHLTPLKT KHIAHWCRCH
GYTPPDPESL RSEGDSIEDV LTQIDSEPEC PSSFSSADNL CRKLEDLQQF QKREPENEEE
VDILSLSEPL KINIKKEQEE KQEEMKFYLP PTPGSEFIGD ITQKIGITLQ PVALHRHVYA
SVVEDMILKA TEQLVSDILR QALAVGYQTV SHNRIPKEIT VSNIHQAICN IPFLDFLTNK
HMGVLSVDP
//
