ID H0VMJ0_CAVPO Unreviewed; 1507 AA.
AC H0VMJ0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=DENN domain containing 4B {ECO:0000313|Ensembl:ENSCPOP00000011622.3};
GN Name=DENND4B {ECO:0000313|Ensembl:ENSCPOP00000011622.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011622.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011622.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011622.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02015637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013014273.1; XM_013158819.1.
DR STRING; 10141.ENSCPOP00000011622; -.
DR Ensembl; ENSCPOT00000013035.3; ENSCPOP00000011622.3; ENSCPOG00000012910.4.
DR GeneID; 100727143; -.
DR CTD; 9909; -.
DR VEuPathDB; HostDB:ENSCPOG00000012910; -.
DR eggNOG; KOG2127; Eukaryota.
DR GeneTree; ENSGT00940000160472; -.
DR HOGENOM; CLU_003074_0_0_1; -.
DR InParanoid; H0VMJ0; -.
DR OMA; VVWPGPI; -.
DR OrthoDB; 1079051at2759; -.
DR TreeFam; TF313237; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012910; Expressed in hypothalamus and 13 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032483; P:regulation of Rab protein signal transduction; IEA:Ensembl.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF18; DENN DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 55..214
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 206..656
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REPEAT 823..857
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 733..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 165449 MW; D22831C99AC48690 CRC64;
MEADAVSEGG VMAEERPPRL VDYFVVAGLA GNRAPIPEET RIPEPSGLLR PSRPAEPITD
VAVIARALGE EVPQGYTCIQ TSAGGHPLEL SAGLLGGTQP VICYRRGRDK PPLVELGVFY
EGKDRPKPGF QVLDTTPYSH SANLAPPGPG HPRTYLTYRR AAEGAGLHAL GITDLCLVLP
SKGEGPPHTY CRLPRNLNPG MWGPAVYLCY KVGLAKANTL VYEAELLGRY PEEDNEAFPL
PESVPVFCLP MGATIECWPA QTKYPVPVFS TFVLTGAAGD KVYGAALQFY EAFPRARLSE
RQAQALGLLS AVERGRALGG RAVRSRRAIA VLSRWPAFPA FRAFLTFLYR YSVSGPHRLP
LEAHISHFIH NVPFPSPQRP RILVQMSPYD NLLLCQPVSS PLPLSGASFL QLLQSLGPEP
AVTLLLAVLT EHKLLVHSLR PDLLTSVCEA LVSMIFPLHW QCPYIPLCPL VLADVLSAPV
PFIVGIHSSY FDLHDPPADV ICVDLDTNTL FPTEEKKPLS PRILPRKPYK VLLATLTNLY
QQLDQTYTGP EEEASLEFLL TDYEAVCGRR VRLEREVQGA FLRFMACLLK GYRDFLRPLT
QAPSEGARDV DNLFFLQGFL KSRERSSHKL YSQLLHTQMF SQFIEECSFG SSRHAALEFF
DSCVDKVHPE QEKPEPTPLV ELEELSGNEL TVFITPPEEP PVPEGSESTP QYCYDGFPEL
RAELFESLQE QAGTLPVPGP TRSAPSSPAP RRTKQEMKVA QRMAQKSAMA PELWARCLLG
HCYGLWFLCL PAYVRSAPSR VRALHTAYHV LREMESRKVV LPDEVCYRVL MQLCSHYGQP
ILSVRVMLEM RRAGIVPNTI TYGYYNKAVL ESKWPSGTPG GRLRWAKLRN VVLGAAQFRQ
PLRDRQQRQQ QQQQQQQQQR QRQQAAAPQE AGSSQTESYV QRPSPTRPLQ RQTTWAGRSL
RDPASPTGRL VKSGSLGSAR GAQPTVEAGV AHIIEALGVL EPRGPPVLWH DGSLSDLSLT
GEELAPGGSP GGSGSALSTQ STEALEGLSR RGSKAGGSQD EMGTPRRGLG ARLQQLLTPS
RRSPASRVSS SEVPSDLPVA ARSSPRDSLL WPRERPGSTA SESSASLGSE WDLSESSVSS
LSLRHSSERL SDTPGSFQPP SLEILLSSCS LCRACDSLVY DEEIMAGWAP DDSNLNTTCP
FCACPFVPLL SVQTFDSRLS ASSPKPAPTG SKDAPVPGGP GPVLSDRRLC LALDEPQLCN
GHMAGAPRRV ESGAWAYLSP LVLRKELESL VENEGSEVLA LPELPAAHPI IFWNLLWYFQ
RLRLPSILPG LVLVSCDGPP HPQAPSPWLT PDPASVQVRL LWDVLTPDPN SCPPLYVLWR
LHSQIPQRVV WPGPVPECLS LALLESVLRH VGLNEVHKAV GLLLETLGPP STGLYLQRGI
YREILFLTLA ALGKDHVDIV AFDKKYKSAF NKLASSMGKE ELRQRRAQMP SPKAIDCRKC
FGAPLEC
//
