ID H0VN66_CAVPO Unreviewed; 399 AA.
AC H0VN66;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Torsin family 3 member A {ECO:0000313|Ensembl:ENSCPOP00000011880.2};
GN Name=TOR3A {ECO:0000313|Ensembl:ENSCPOP00000011880.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011880.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011880.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011880.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235}.
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DR EMBL; AAKN02017691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003474990.2; XM_003474942.3.
DR AlphaFoldDB; H0VN66; -.
DR STRING; 10141.ENSCPOP00000011880; -.
DR Ensembl; ENSCPOT00000013324.3; ENSCPOP00000011880.2; ENSCPOG00000013197.4.
DR GeneID; 100717295; -.
DR KEGG; cpoc:100717295; -.
DR CTD; 64222; -.
DR VEuPathDB; HostDB:ENSCPOG00000013197; -.
DR eggNOG; KOG2170; Eukaryota.
DR GeneTree; ENSGT00950000182888; -.
DR HOGENOM; CLU_053537_0_0_1; -.
DR InParanoid; H0VN66; -.
DR OMA; VARMMVF; -.
DR OrthoDB; 5087at2759; -.
DR TreeFam; TF314941; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013197; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR PANTHER; PTHR10760; TORSIN; 1.
DR PANTHER; PTHR10760:SF3; TORSIN-3A; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..399
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003542818"
FT DOMAIN 340..397
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
SQ SEQUENCE 399 AA; 45376 MW; A5D769B66D2F0EE6 CRC64;
MPRRWRRAVG LSFLLLLLLA GAPGCRGAER LWEGADEPGP AWGWPGLQRV REQLRAAGAL
SRRYWALLSC QVWPDDCEAD GEAAAGRLGQ TLIQLGQRSL DALTTWYCSF RDCCNGGDCR
ISNDFSGLDS DLSVRLHGQH LARELVFRTV RGYLEMPQPD KALALSFHGW SGTGKNFVAR
MVAENLYRDG LKSDCVKVFI TTIHFPHSKY VDLYKELLTD QIKQVQQRCH QSLFIFDEAE
KLHPELLELL GPHLERQALE GHRTKSPRAI FLFLSNLGGN VINKVVLNLL KAGWAREEIS
MEHLQAHLQA EIKESTESGF GHSRLVKDNL IDFFVPFLPL EYRHVRLCAR DAFQSQELLY
TEETLDEVAK MMTYVPKEEK LFSSQGCKSV SQRINYFLP
//
