ID H0VNR4_CAVPO Unreviewed; 710 AA.
AC H0VNR4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Transglutaminase 7 {ECO:0000313|Ensembl:ENSCPOP00000012101.3};
GN Name=TGM7 {ECO:0000313|Ensembl:ENSCPOP00000012101.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012101.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012101.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012101.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AAKN02015939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VNR4; -.
DR STRING; 10141.ENSCPOP00000012101; -.
DR Ensembl; ENSCPOT00000013572.3; ENSCPOP00000012101.3; ENSCPOG00000013440.4.
DR VEuPathDB; HostDB:ENSCPOG00000013440; -.
DR eggNOG; ENOG502QTRA; Eukaryota.
DR GeneTree; ENSGT01050000244866; -.
DR HOGENOM; CLU_013435_1_0_1; -.
DR InParanoid; H0VNR4; -.
DR OMA; TDHITFV; -.
DR TreeFam; TF324278; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013440; Expressed in adult mammalian kidney.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF41; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE Z; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 271..364
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 279
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 338
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 361
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 401
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 403
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 450
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 710 AA; 79854 MW; 56DF9B9A64215122 CRC64;
SDQLAALELR SVDLHSARNN KEHHTQEMGV ERLILRRGQL FSLQLAFNRP FQPHSDHITF
VAETGPEPSE LLGTRARFFL TQAQHGNVWN VSDFTVDSIS LQVSLFTPAS AAIGHYTLRM
EIAQSQGHSL TYLLGTFILL FNPWSTEDDV YLPSETLLQE YIMRDYGFVY KGHDSFITSW
PWNYGQFEKD IIDICFEILN KSLYFLKNPA KDHSQRNDVV YVCRVVSAMI NSNDDSGVLE
GNWGEDYSRG ISPLEWNGSV AILRQWSAQG GQPVKYGQCW VFASVMCTVM RCLGVPTRVV
SNFHSAHNTD GNLTIDTYYD RSAEMLPTQK RDQVWNFHVW NECWMIRKDL PPGYNGWQVL
DPTPQQTSSR LFCCGPASVK AIKEGDVHLA YDTPFVFAEV NADEVIWLFE DGTVQEILAH
NASAIGKEIS TKMVGSDQRQ DITYVYKYPE GSPEERSVFM KASRKMLGQE GASSSLLDLL
GSAAFKSQPA RLRLYLARAP TWGQDLLLTL HVQRVRDSTH RQGPIRLEVR FCAQALLHGG
GTREPLWKQA VHLDLDFGQE IHWPLLLPFT NYRNKLTDEK LIRMSGIAKD EETGRSMLVV
KDLCLEPPHL SIEVSQTAEV GKALKVQISL TNTLTVALND CTMVLEGSGL INGQITEELG
TLKSGDTIQI HLDLYPSKAG PRQLQVLISS SEIKEMKGYK DIFVAAAAAP
//
