ID H0VNU9_CAVPO Unreviewed; 403 AA.
AC H0VNU9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=DEP domain containing MTOR interacting protein {ECO:0000313|Ensembl:ENSCPOP00000012148.2};
GN Name=DEPTOR {ECO:0000313|Ensembl:ENSCPOP00000012148.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012148.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012148.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012148.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAKN02000094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479890.1; XM_003479842.3.
DR AlphaFoldDB; H0VNU9; -.
DR STRING; 10141.ENSCPOP00000012148; -.
DR Ensembl; ENSCPOT00000013626.3; ENSCPOP00000012148.2; ENSCPOG00000013492.4.
DR GeneID; 100721956; -.
DR KEGG; cpoc:100721956; -.
DR CTD; 64798; -.
DR VEuPathDB; HostDB:ENSCPOG00000013492; -.
DR eggNOG; ENOG502QS4Y; Eukaryota.
DR GeneTree; ENSGT00520000055667; -.
DR HOGENOM; CLU_042535_0_0_1; -.
DR InParanoid; H0VNU9; -.
DR OMA; HVCDDHL; -.
DR OrthoDB; 2953750at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013492; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0045792; P:negative regulation of cell size; IEA:Ensembl.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR GO; GO:1903940; P:negative regulation of TORC2 signaling; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR CDD; cd04442; DEP_1_DEP6; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR037335; DEPTOR_DEP_1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF18; DEP DOMAIN-CONTAINING MTOR-INTERACTING PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 30..113
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 145..213
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 324..401
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 44921 MW; 45796E4317E21A12 CRC64;
MEQGSSGSDG HPGGGARQRE LERTAEVLVT GEQLRLRLHE EKVIKDRRHH LKTYPNCFVA
KELVDWLLAH KEASDRETAV RLMQKLADRG IIHHVCDEHK EFKDAKLLYR FRKDDGTFPL
DGEVKACVRG QRLYEKLMSP DCALLQPREE DGVRYERTFV ASELLDWLVQ EGEATTRPEA
EQLCRRLVEQ GIVQHVSGKR PFTDSNLLCQ FRTNFRRRRR LMELLSEPTP GAPDTHDSPF
CPRRQSHDAR KATSFVSVSP SKEIKVASVG RRSSLSSGGS SGYFSSSPTL GSSPPVLCNP
KSVLKRPVTS EELLSPGAPY ARKTFTIVGD AVGWGFVVRG SKPCHIQAVD PSGPAAAAGM
KVCQFVVSVN GLNVLHVDYR TVSHLILTGP RTIVMEVMEE LES
//