GenomeNet

Database: UniProt
Entry: H0VNU9_CAVPO
LinkDB: H0VNU9_CAVPO
Original site: H0VNU9_CAVPO 
ID   H0VNU9_CAVPO            Unreviewed;       403 AA.
AC   H0VNU9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=DEP domain containing MTOR interacting protein {ECO:0000313|Ensembl:ENSCPOP00000012148.2};
GN   Name=DEPTOR {ECO:0000313|Ensembl:ENSCPOP00000012148.2};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012148.2, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012148.2}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012148.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAKN02000094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003479890.1; XM_003479842.3.
DR   AlphaFoldDB; H0VNU9; -.
DR   STRING; 10141.ENSCPOP00000012148; -.
DR   Ensembl; ENSCPOT00000013626.3; ENSCPOP00000012148.2; ENSCPOG00000013492.4.
DR   GeneID; 100721956; -.
DR   KEGG; cpoc:100721956; -.
DR   CTD; 64798; -.
DR   VEuPathDB; HostDB:ENSCPOG00000013492; -.
DR   eggNOG; ENOG502QS4Y; Eukaryota.
DR   GeneTree; ENSGT00520000055667; -.
DR   HOGENOM; CLU_042535_0_0_1; -.
DR   InParanoid; H0VNU9; -.
DR   OMA; HVCDDHL; -.
DR   OrthoDB; 2953750at2759; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000013492; Expressed in ovary and 13 other cell types or tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
DR   GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0045792; P:negative regulation of cell size; IEA:Ensembl.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR   GO; GO:1903940; P:negative regulation of TORC2 signaling; IEA:Ensembl.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   CDD; cd04442; DEP_1_DEP6; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR037335; DEPTOR_DEP_1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR22829:SF18; DEP DOMAIN-CONTAINING MTOR-INTERACTING PROTEIN; 1.
DR   Pfam; PF00610; DEP; 2.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50186; DEP; 2.
DR   PROSITE; PS50106; PDZ; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN          30..113
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          145..213
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          324..401
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  44921 MW;  45796E4317E21A12 CRC64;
     MEQGSSGSDG HPGGGARQRE LERTAEVLVT GEQLRLRLHE EKVIKDRRHH LKTYPNCFVA
     KELVDWLLAH KEASDRETAV RLMQKLADRG IIHHVCDEHK EFKDAKLLYR FRKDDGTFPL
     DGEVKACVRG QRLYEKLMSP DCALLQPREE DGVRYERTFV ASELLDWLVQ EGEATTRPEA
     EQLCRRLVEQ GIVQHVSGKR PFTDSNLLCQ FRTNFRRRRR LMELLSEPTP GAPDTHDSPF
     CPRRQSHDAR KATSFVSVSP SKEIKVASVG RRSSLSSGGS SGYFSSSPTL GSSPPVLCNP
     KSVLKRPVTS EELLSPGAPY ARKTFTIVGD AVGWGFVVRG SKPCHIQAVD PSGPAAAAGM
     KVCQFVVSVN GLNVLHVDYR TVSHLILTGP RTIVMEVMEE LES
//
DBGET integrated database retrieval system