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Database: UniProt
Entry: H0VP34_CAVPO
LinkDB: H0VP34_CAVPO
Original site: H0VP34_CAVPO 
ID   H0VP34_CAVPO            Unreviewed;       486 AA.
AC   H0VP34;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   10-APR-2019, entry version 42.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL4 {ECO:0000313|Ensembl:ENSCPOP00000012239};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012239};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012239}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012239};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012239}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012239};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AAKN02017418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003475093.1; XM_003475045.1.
DR   STRING; 10141.ENSCPOP00000012239; -.
DR   Ensembl; ENSCPOT00000013730; ENSCPOP00000012239; ENSCPOG00000013594.
DR   GeneID; 100713959; -.
DR   CTD; 23553; -.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H0VP34; -.
DR   OrthoDB; 1096692at2759; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0030207; P:chondroitin sulfate catabolic process; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   ACT_SITE    147    147       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    368    368       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     59    351       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    223    237       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    376    387       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    381    435       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    437    446       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   486 AA;  55372 MW;  1112669F02879360 CRC64;
     MKLVAEGQFR LCVIQSIHLT PWLLVFLSLK SVCSLKPARL PLYQRKPFIA AWNTPTDQCL
     MKYKLRLNLE MFQVAGSTLT KARGQNVTIF YPRRLGYYPW YTSQGVPING GLPQNTSLKV
     HLKKVDQDIK YYIPVKDFRG LAVIDWEYWR PQWDRNWNAK DVYRRKSKEL IFDLQQNVKA
     SDIEYLAKAT FEESAKAFMI ETIKLGIKRR PKGLWGYYLY PDCHNYNMDD PSYTGSCPEE
     EVLKNNELSW LWDSSTALYP SVVIKKSLRN SENVLHFSKF RVQEAMRIST MTSHKYALPV
     FVYTRLGYRE DPLFFLSQQD LINTIGESAA LGAAGIVIWG DMNLTLSEDN CTKVKQFVSS
     DLGSYIVNVS TAAEICSLHL CRSNGRCVRK MWNASDYLHL SNKSYRIETS GNGGFTAKGN
     VSDADLIVMK QKFFCQCYQG HEGANCQEMK EVDGSTGLSS CPGLLMTLCL LSLASYHNIQ
     VGDNAG
//
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