ID H0VP44_CAVPO Unreviewed; 1590 AA.
AC H0VP44;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=TIAM Rac1 associated GEF 1 {ECO:0000313|Ensembl:ENSCPOP00000012249.3};
GN Name=TIAM1 {ECO:0000313|Ensembl:ENSCPOP00000012249.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012249.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012249.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012249.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02041958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02041959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02041960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013005211.1; XM_013149757.1.
DR STRING; 10141.ENSCPOP00000012249; -.
DR Ensembl; ENSCPOT00000013742.3; ENSCPOP00000012249.3; ENSCPOG00000013606.4.
DR VEuPathDB; HostDB:ENSCPOG00000013606; -.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000156294; -.
DR HOGENOM; CLU_000494_3_0_1; -.
DR InParanoid; H0VP44; -.
DR OMA; MQFYIPQ; -.
DR OrthoDB; 25601at2759; -.
DR TreeFam; TF319686; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013606; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 438..546
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 764..831
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 844..907
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1039..1233
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 552..579
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 21..45
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1590 AA; 177148 MW; 3EBFD39E6CAD0FA2 CRC64;
MGNAESQNVD HEFYREKHAS LGRKHTSRSL RLSHKTRRTR HASSGKAIHR NSEVSTRSSS
TPSIPQSLAE NGLEPFAQEG TLEDFGSPIW VDRVDMGLRP VSYTDSSVTP SVDSSIVLTA
ASVQSMPDSE ESRLYGDDAT YLAEGGRRQH PYASNGPTFM ETASFKKKRS KSADIWREDS
LEFSLSDLSQ EHLTSNEEIL GSAEEKDSEE ARGMETRASP RQLGTCQRAN SLGDLYAQKN
SGVTANGGPR SKFSGCCRNL VSDIPDLANH KMPPAAAEET ALYSNYNTLP CRKSHCLSEG
VSNPQISHSN SMRGRRAKTT QDVNAGEGSE FADSGIEGAA TDTDLLSRRS NATNSSYSPP
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTNSESL EEAGSAHSDE QSSGTLSSPG
QSDILLTAAQ GTVRKAGALA VKNFLVHKKN KKVESATRRK WKHYWVSLKG CTLFFYESDG
RSGIDHNSIP KHAVWVENSI VQAVPEHPKK DFVFCLSNSL GDAFLFQTTS QTELENWITA
IHSACAAAVA RHHHKEDTLR LLRSEIKKLE QKIDMDEKMK KMGEMQLSSV TDSKKKKTIL
DQIFVWEQNL EQFQMDLFRF RCYLASLQGG ELPNPKRLLA FASRPTKVAM GRLGIFSVSS
FHALVAARTG ETGVRRRTQA MSRSASKRRS RFSSLWGLDT TSKKKQGRPS INQVFGEGTD
AVKKSLEGLF DDIVPDGKRE KEVVLPSVHQ HNPDCDIWVH EYFTPSWFCL PNNQPALTVV
RPGDTARDTL ELICKTHQLD HSAHYLRLKF LIENKMQFYI PQPEEDIYEL LYKEIEICPK
VTQNIQIEKS DTAADNYGFS LSSVEEDGVR RLYVNSVKET GLASKKGLKA GDEILEINNR
TAGTLNSSML KDFLSQPSLG LLVRTCPKLE AGVELLESPP HRVDGPADLG ESPLAFLTSN
PGHSLCSEQS SSAETAPDET DGPDLESSDE TDHSSKSTEQ VAVFCRSLHE MNPSDSSPSP
PDATGPQLAT MRQLSDADKL RKVICELLET ERTYVKDLNC LMERYLKPLQ KEPFLTQDEL
DVLFGNLTEM VEFQVEFLKT LEDGVRLVPD LEKLEKVDQF KKVLFSLGGS FLYYADRFKL
YSAFCASHTK VPKVLVKAKT DTAFKAFLDA QNPRQQHSST LESYLIKPIQ RILKYPLLLK
ELFALTDAES EEHYHLDVAI KTMNKVASHI NEMQKIHEEF GAVFDQLIAE QTGEKKEVAD
LSMGDLLLHT TVIWLNPPAS LGKWKKEPEL AAFVFKTAVV LVYKDGSKQK KKLVGSHRLS
IYEEWDPFRF RHMIPTEALQ VRALASADAE ANAVCEIVHV KSESEGRPER VFHLCCSSPE
SRKDFLKAVH SILRDKHRRQ LLKTESLPSS QQYVPFGGKR LCALKGARPA MSRAVSAPSK
SLGRRRRRLA RNRFTIDSDA VSAGSPEKEP QQPPGGGDTD QWVEEQFDLA QYEEQDDIKE
TDILSDDDEF CESVKGASVD TDLQERLQAA SISHRERGRK SLDSHASRMA QLKKQAALSG
INGGLESTSE EVIWVRREDF GPSRKLNTEI
//
