ID H0VP46_CAVPO Unreviewed; 900 AA.
AC H0VP46;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN Name=OCRL {ECO:0000313|Ensembl:ENSCPOP00000012251.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012251.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012251.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012251.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR EMBL; AAKN02054408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012997656.1; XM_013142202.1.
DR AlphaFoldDB; H0VP46; -.
DR STRING; 10141.ENSCPOP00000012251; -.
DR Ensembl; ENSCPOT00000013744.3; ENSCPOP00000012251.3; ENSCPOG00000013608.4.
DR GeneID; 100733180; -.
DR KEGG; cpoc:100733180; -.
DR CTD; 4952; -.
DR VEuPathDB; HostDB:ENSCPOG00000013608; -.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000157996; -.
DR HOGENOM; CLU_006779_3_1_1; -.
DR InParanoid; H0VP46; -.
DR OMA; NVNNKPC; -.
DR OrthoDB; 21647at2759; -.
DR TreeFam; TF317034; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013608; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:Ensembl.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:Ensembl.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd13382; PH_OCRL1; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 2.30.29.110; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR037787; OCRL1_PH.
DR InterPro; IPR031995; OCRL_clath-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF176; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF16726; OCRL_clath_bd; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 720..900
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 161..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 104098 MW; 6E519C424F268EC9 CRC64;
MEPLLPIGAQ PLATIEGLEM KGPLREPCAL TLAQRNGQYE FIIQLQEKEH VQDIIPINSH
FRCVQEAEET LLIDIASNSG CKIRVQGDWT RERRFEIPDE EHCLKFLSEV LAAQEAQSQL
LVPEQKDSSS WYQKLDTKDK PSIFPGLLGF EDNFSSMNLD KKMNSQNQST GIHREPPPPP
PSVNRMLPRE KEASNKELPK VTNTMRKLFV PNTQSGTREG LIKHILAKRE KEYVNIQTFK
FFVGTWNVNG QSPDSGLEPW LNCDPNPPDI YCIGFQELDL STEAFFYFES VKEQEWCMAV
ERGLHSKAKY KKVQLVRLVG MMLLIFARKD QYRYIRDVAT ETVGTGIMGK MGNKGGVAVR
FVFHNTTFCI VNSHLAAHVE DFERRNQDYK DICARMSFVV PSQTLPQLNI MKHDVVIWLG
DLNYRLCMPD ANEVKSLINK NDLQRLLKFD QLNIQRTQKK AFIDFNEGEI KFIPTYKYDS
KTDRWDSSGK CRIPAWCDRI LWRGTNVNQL NYRSHMELKT SDHKPVSALF HIGVKVVDER
RYRKVFEDIV RIMDRMENDF LPSLELSRRE FVFENVKFRQ LQKEKFQISN NGQVTCHFSF
IPKLNDSQYC KPWLRAEPFE GYLEPNETVD ISLDVYVSKD SVTILNSGED KIEDILVLHL
DRGKDYFLTI SGNYLPSCFG TSLEALCRMK RPIREVPVTK LIDLEEDSFL EKEKSVLQMV
PLDEGASERP LQVPKEIWLL VDHLFKYACH QEDLFQTPGM QEELQQIIDC LDTSIPETIP
GSNHSVAEAL LIFLEALPEP VICYELYQRC LDSAHDPRIC RQIISQLPRC HRNVFRYLMA
FLRELLKFSE YNNVSANMIA TLFTSLLLRP PPNLMARPTS SDRQRAIQFL LGFLLGSDED
//
