ID H0VP51_CAVPO Unreviewed; 1163 AA.
AC H0VP51;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=TBC1 domain family member 1 {ECO:0000313|Ensembl:ENSCPOP00000012257.3};
GN Name=TBC1D1 {ECO:0000313|Ensembl:ENSCPOP00000012257.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012257.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012257.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012257.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02027991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02027994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VP51; -.
DR Ensembl; ENSCPOT00000013751.3; ENSCPOP00000012257.3; ENSCPOG00000013615.4.
DR VEuPathDB; HostDB:ENSCPOG00000013615; -.
DR eggNOG; KOG4436; Eukaryota.
DR GeneTree; ENSGT00940000157949; -.
DR HOGENOM; CLU_005350_13_0_1; -.
DR TreeFam; TF317184; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013615; Expressed in testis and 13 other cell types or tissues.
DR CDD; cd00934; PTB; 1.
DR CDD; cd01269; PTB_TBC1D1_like; 1.
DR Gene3D; 1.10.10.2750; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR021785; DUF3350.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF18; TBC1 DOMAIN FAMILY MEMBER 1 ISOFORM X1; 1.
DR Pfam; PF11830; DUF3350; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 290..369
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 795..989
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 208..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 132277 MW; E480D2C68F79BBAD CRC64;
MEPITFTARK HPFPSEVSIN FGLQLVGSLP VHSLTTMPML PWVVAEVRRL SGQSSKKEPV
VRPVRLWVSP SGLRCEPDPG RSQQWDPLIC SSIFECKPQR VHKLIHNSHD PSYFACLIKE
DAAHRQSICY VFKADDQTKV PEIISSIRQA GKIARQEELR CPSEFDDTFA KKFEVLFCGR
VTVAHKKAPP ALIDECIEKF NHISSSLRAD GEPASVPSPG AARRRPMRKS QSQPGLRSLA
YRREFQDGGL RSSSFFSSFE ENDIENHLIS GHHIVQPTDI EENRTMLFTI GQSEVYLISP
DTKKIALEKN FKEISFCSQG IRHVDHFGFI CREALGGGGF HFVCYVFQCA NEALVDEIMM
TLKQAFTVAA VQQTAKAPAQ LCEACPLQGL HKLCERIEGM NSSKTKLELQ KHLTTLTNQE
QATIFEEVQK LRPRNEQREN ELIISFLRCL YEEKQKEHIH IGEMKQTPQI AAENIGSELP
ASAPRFRLDM LKNKAKRSLT ESLESILSRG SKARGLQEHS ASVDLDSSVS STLSSTSKEP
STGDKEALPV SESSFKLLGS SDDLSSDSES HPLEEPAPLS PQQAFRRRAN TLSHFPVQCP
APPEPAQGSP GVIQRKLMRY HSVSTETPHE RKDFESKADH LEDVGETPVK TRRHSWRQQI
FLRVATPQKA SDSPGRFEDY SELGELPPRS PLEPVCEDGP FGPVPEEKKR TPRELRELWR
KAILQQILLL RMEKENQKLQ ASENDLLNKR LKLDYEEITP CLKEVTTVWE KMLSFPGRSK
TKFDMEKMHS AVGQGVPRHH RGEIWKFLAE QFHLKHPFPS KQQPKDVPYK ELLKQLTSQQ
HAILIDLGRT FPTHPYFSAQ LGAGQLSLYN ILKAYSLLDQ EVGYCQGLSF VAGILLLHMS
EEEAFKMLKF LMFDMGLRKQ YRPDMIILQI QMYQLSRLLH DYHRDLYDHL EEHEIGPSLY
AAPWFLTVFA SQFPLGFVAR VFDMIFLQGS EVIFKVALSL LGSHKPLILQ HENLETIVDF
IKNTLPNLGL VQMEKTINQV FEMDIAKQLQ AYEVEYHVLQ EELIDSSPLS DNQRMDKLEK
TNSSLRKQNL DLLEQLQVAH SKIQSLEATV EKLLTNENKL KQAVLTLEGE RTALLEMVEK
LRRRPEELSA GQPDHSQHEP TGD
//
