ID H0VPH8_CAVPO Unreviewed; 860 AA.
AC H0VPH8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Transcription factor E2F8 {ECO:0000256|ARBA:ARBA00039673};
GN Name=E2F8 {ECO:0000313|Ensembl:ENSCPOP00000012402.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012402.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012402.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012402.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; AAKN02053489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003462648.1; XM_003462600.2.
DR RefSeq; XP_012999810.1; XM_013144356.1.
DR STRING; 10141.ENSCPOP00000032943; -.
DR Ensembl; ENSCPOT00000013906.3; ENSCPOP00000012402.3; ENSCPOG00000013766.4.
DR Ensembl; ENSCPOT00000043444.1; ENSCPOP00000032943.1; ENSCPOG00000013766.4.
DR GeneID; 100723781; -.
DR KEGG; cpoc:100723781; -.
DR CTD; 79733; -.
DR VEuPathDB; HostDB:ENSCPOG00000013766; -.
DR eggNOG; KOG2578; Eukaryota.
DR GeneTree; ENSGT00940000158651; -.
DR HOGENOM; CLU_014845_2_0_1; -.
DR OMA; FFEPHKK; -.
DR OrthoDB; 1761at2759; -.
DR TreeFam; TF105567; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013766; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0033301; P:cell cycle comprising mitosis without cytokinesis; IEA:Ensembl.
DR GO; GO:0060718; P:chorionic trophoblast cell differentiation; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0032466; P:negative regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0032877; P:positive regulation of DNA endoreduplication; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF40; TRANSCRIPTION FACTOR E2F8; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 108..177
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 256..342
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 93471 MW; 331158CE32176CE9 CRC64;
MDNEKENLFI EPHKRGLMRS PLKESTKENV SPNLGPLTTP TKPKEVSQGE PWTPTANLKM
LISAVSPEIR SRDQKRGLFD NRMGLPEAKD CLQEHLSGDE YEKSQPSRKE KSLGLLCHKF
LARYPKYPNP AVNNDICLDE VAEELNVERR RIYDIVNVLE SLHMVSRLAK NRYTWHGRHN
LNKTLGTLKS VGEENKYAEQ IMMIKKKEYE QEFDFIKSYS IEDHIIKSNT GQNGHTEMCF
VELPGMEFRA ASVNSRKDKS LRVMSQKFVM LFLVSTPQIV SLEIAAKILI GEDHVEDLDK
SKFKTKIRRL YDIANVLSSL DLIKKVHVTE ERGRKPAFKW TGPEISPNTS GSSPVLPSAT
SDLGVRRSAK ENCAKNLFST RGKPNFTRHP SLIKLVKSIE SDRRKINSAP SSPVKHSKAE
SSQNSPPFPN KMAQLAAICK MQLEEQSEPL KKMKVQLARS GHCKPVTLLD ASANTELELT
TPSLIQPLGV VPLVPSPLSP AVPVILPQAA SGPSYAIYLQ PAQTQTVTPP QGLSPTVCPT
HCSKATRAKD STDATTEKAT NSASRASSSS RAGSLLPAPE RQGAKNQTKE APGERGSKRS
SMFEDCVSKK KYKEDLKGLE NMSATLFPGY LIPLTQCSSL GAESILSNKE NSGTPSPNHR
IYSSPIAGVI PVTSSELTAV NFPSFHVTPL KLMVSPTSVA AVHGGNSPAL ASSHPIAIQN
PSSAIVNFTL QHLGLISPSV QVSASPGPGS GTIPVSPKIE AISVVPEHAG CQQGKATSSD
SPVPGQSQPN GQSVTVTGTQ QPVPVTPKGS ELVAESFFRT PGGPTKPAGL SCVDFDGASK
TFGTFFVPQR KLEVSTEDVH
//
