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Database: UniProt
Entry: H0VPI4_CAVPO
LinkDB: H0VPI4_CAVPO
Original site: H0VPI4_CAVPO 
ID   H0VPI4_CAVPO            Unreviewed;       727 AA.
AC   H0VPI4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   SubName: Full=Leucine rich repeat and sterile alpha motif containing 1 {ECO:0000313|Ensembl:ENSCPOP00000012409.2};
GN   Name=LRSAM1 {ECO:0000313|Ensembl:ENSCPOP00000012409.2};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012409.2, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012409.2}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012409.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AAKN02030238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02030239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003470807.1; XM_003470759.3.
DR   RefSeq; XP_013008797.1; XM_013153343.1.
DR   RefSeq; XP_013008798.1; XM_013153344.1.
DR   RefSeq; XP_013008799.1; XM_013153345.1.
DR   RefSeq; XP_013008800.1; XM_013153346.1.
DR   STRING; 10141.ENSCPOP00000027314; -.
DR   Ensembl; ENSCPOT00000013913.3; ENSCPOP00000012409.2; ENSCPOG00000013773.4.
DR   Ensembl; ENSCPOT00000044519.1; ENSCPOP00000027314.1; ENSCPOG00000013773.4.
DR   GeneID; 100727397; -.
DR   KEGG; cpoc:100727397; -.
DR   CTD; 90678; -.
DR   VEuPathDB; HostDB:ENSCPOG00000013773; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00930000151044; -.
DR   HOGENOM; CLU_022990_0_0_1; -.
DR   OMA; FWLLQYQ; -.
DR   OrthoDB; 1043058at2759; -.
DR   TreeFam; TF329645; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000013773; Expressed in thyroid gland and 13 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0045806; P:negative regulation of endocytosis; IEA:Ensembl.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR   GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:Ensembl.
DR   GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR   CDD; cd16515; RING-HC_LRSAM1; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF19; LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00364; LRR_BAC; 4.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          578..632
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          679..714
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          638..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          325..376
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          511..546
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   727 AA;  84101 MW;  3F44E1F9D1DABA7D CRC64;
     MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LTEIPFGAFA TCKVLQKKVL
     IVHTNQLTFL LPKSCSLLSL ATIKVLDLHS NQLTALPDDM GQLTALQVLN VERNQLTYLP
     RSIGNLAQLQ TLNVKDNKLK ELPDTLGELR SLRTLDISEN GIKRLPQMLA HVRTLETLSL
     DALAMVFPPP EVCSNGTAAI QQFLCKESGL EYYPPSQYLL PVLEQDGADS VRDSPDRPPD
     RFSREEAEWQ NKFSDYEKRK EQKMLEKLEF ERRLELGQRQ HAQLLRQSHI QKDEVLQTLR
     EEQSRLEQGL SEHQRYLDGE RQRLLQQLKE AEQSVTGRIQ KLLQENRRQK QSSEILKSLE
     NERIRMEQLM AITQEETENL RRREIASAMQ QMLTESCKSR LVQMAYESQR QSLVRQACSS
     MAEMDERFQQ ILSWQQMDQN KAITQILQES SMQKAAFEAL QVKKDRMHRQ IRNQIRLIET
     ELLQLTQLEL KRKSLDTETL QEVVAEQRWA LSSLLQQLLK EKKQREEELR DLLAELEAKS
     ETKQENYWLI QYQRLLNQKP LSLRLQEEGM ERQLVAILVE LSAKHYLPIF AHHRISLDML
     SRMSPGDLAK VGVSEAGLQH EILQKVWELR DVARTQPELK PPKGEVVETP EPPTAPLEPA
     ELVRPSAPPA EPKVQMSECV VCLEQEAQTV FLPCGHVCCC QQCCQPLRTC PLCRRDIAQS
     LRIYHSS
//
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