ID H0VPI4_CAVPO Unreviewed; 727 AA.
AC H0VPI4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Leucine rich repeat and sterile alpha motif containing 1 {ECO:0000313|Ensembl:ENSCPOP00000012409.2};
GN Name=LRSAM1 {ECO:0000313|Ensembl:ENSCPOP00000012409.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012409.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012409.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012409.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAKN02030238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02030239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003470807.1; XM_003470759.3.
DR RefSeq; XP_013008797.1; XM_013153343.1.
DR RefSeq; XP_013008798.1; XM_013153344.1.
DR RefSeq; XP_013008799.1; XM_013153345.1.
DR RefSeq; XP_013008800.1; XM_013153346.1.
DR STRING; 10141.ENSCPOP00000027314; -.
DR Ensembl; ENSCPOT00000013913.3; ENSCPOP00000012409.2; ENSCPOG00000013773.4.
DR Ensembl; ENSCPOT00000044519.1; ENSCPOP00000027314.1; ENSCPOG00000013773.4.
DR GeneID; 100727397; -.
DR KEGG; cpoc:100727397; -.
DR CTD; 90678; -.
DR VEuPathDB; HostDB:ENSCPOG00000013773; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00930000151044; -.
DR HOGENOM; CLU_022990_0_0_1; -.
DR OMA; FWLLQYQ; -.
DR OrthoDB; 1043058at2759; -.
DR TreeFam; TF329645; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013773; Expressed in thyroid gland and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0045806; P:negative regulation of endocytosis; IEA:Ensembl.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR CDD; cd16515; RING-HC_LRSAM1; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF19; LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 578..632
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 679..714
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 638..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 325..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 511..546
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 84101 MW; 3F44E1F9D1DABA7D CRC64;
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LTEIPFGAFA TCKVLQKKVL
IVHTNQLTFL LPKSCSLLSL ATIKVLDLHS NQLTALPDDM GQLTALQVLN VERNQLTYLP
RSIGNLAQLQ TLNVKDNKLK ELPDTLGELR SLRTLDISEN GIKRLPQMLA HVRTLETLSL
DALAMVFPPP EVCSNGTAAI QQFLCKESGL EYYPPSQYLL PVLEQDGADS VRDSPDRPPD
RFSREEAEWQ NKFSDYEKRK EQKMLEKLEF ERRLELGQRQ HAQLLRQSHI QKDEVLQTLR
EEQSRLEQGL SEHQRYLDGE RQRLLQQLKE AEQSVTGRIQ KLLQENRRQK QSSEILKSLE
NERIRMEQLM AITQEETENL RRREIASAMQ QMLTESCKSR LVQMAYESQR QSLVRQACSS
MAEMDERFQQ ILSWQQMDQN KAITQILQES SMQKAAFEAL QVKKDRMHRQ IRNQIRLIET
ELLQLTQLEL KRKSLDTETL QEVVAEQRWA LSSLLQQLLK EKKQREEELR DLLAELEAKS
ETKQENYWLI QYQRLLNQKP LSLRLQEEGM ERQLVAILVE LSAKHYLPIF AHHRISLDML
SRMSPGDLAK VGVSEAGLQH EILQKVWELR DVARTQPELK PPKGEVVETP EPPTAPLEPA
ELVRPSAPPA EPKVQMSECV VCLEQEAQTV FLPCGHVCCC QQCCQPLRTC PLCRRDIAQS
LRIYHSS
//