ID H0VPY8_CAVPO Unreviewed; 1446 AA.
AC H0VPY8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Pleckstrin homology, MyTH4 and FERM domain containing H2 {ECO:0000313|Ensembl:ENSCPOP00000012584.3};
GN Name=PLEKHH2 {ECO:0000313|Ensembl:ENSCPOP00000012584.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012584.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012584.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012584.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02023895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02023896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000014107.3; ENSCPOP00000012584.3; ENSCPOG00000013966.4.
DR VEuPathDB; HostDB:ENSCPOG00000013966; -.
DR eggNOG; KOG0248; Eukaryota.
DR GeneTree; ENSGT00940000157675; -.
DR HOGENOM; CLU_001626_3_1_1; -.
DR InParanoid; H0VPY8; -.
DR OMA; WCILIGK; -.
DR TreeFam; TF312866; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013966; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0030835; P:negative regulation of actin filament depolymerization; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17179; FERM_F1_PLEKHH2; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 698..872
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 908..1063
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1074..1404
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 212..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 212..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1430..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 163474 MW; 284AB160328E7396 CRC64;
MAELSEPEGP VDWKERCVAL ESQLIKFRVQ ASKIRELLAE KMQQLERQVI DAERQAEKAF
QQVQVMEEKL KTANIQTSES ETRLYKKCQD LESLIQEKDD IIQNLELQLE EQKQIRIQEA
KIIEEKAAKI KEWVTIKLNE LELDNQNLRL INQKQNEEIR AIQSKLQEVQ EKKLSAVATP
KLSEGQRLSS LTFGCFLSRA RSPPQIVKYE ETSKLSSKEA EFTKEKNIEE IPEKFADNQV
QENDRGPRTL PQTCCSSEQK RKTRTSCATD GGTSQNSVAP ASDWSSDEED GSKERPKSRC
TSTLSSHTSE EGAHGGRRGS EAYLTASDDS SSIFEEETFG IKRPEHKKLY SWQLEAQWKA
QNSLGKGSSE LNKKEQDCSS EELSKRFQSQ RLDYSSSSSE ANTPSPILSP ALVPKHPNLL
PGKRTPLAPS ARLPPPRLRI PNAFSKSVAL AKRHLSQPQL SSDRMFGTNR NAISMIRPLK
PQETDLDLID CDGEVLENMD TSCDDGLFSC VSLESPYADD QEPGDSAKKA AASKPPTPPL
HRFPSWESRI YAVAKSGIRM SEACNMENVN KNSATMLSNS TSGLYTSLIY KNLTTPVYTT
LKGKATQISS NAFQDDDSSE EEDGSRCSLQ TSELEPRRRS GPGSPRPLKR GVSLTSVASE
NDYAIPPDAY STDTECAQPE QKLPKTCSSS SENGKNEPLE KSGYLLKMSG KVKTWKRRWF
VLKGGELLYY KSPSDVIRKP QGHIELSASC SIVRGDNKQT VQLMTEKHTY YLSVKHGYSK
RVWCILIGKM LYYFRSQEDK FPLGQIKLWE AKVEEVDRSC DSDEDYEASG RSLLSTHYTV
VVHPKDQGPT YLLIGSKHEK DTWLYHLTVA AGSNNVNVGS EFEQLVCKLL NIEGEPSSQI
WRHPTLCHSK EGILSPLTSL PSEALQTEAI KLFKTCQLFI NAAVDSPAID YHISLAQSAL
QICLTHPELQ NEICCQLIKQ TRRRQPQNQP GPLQGWQLLA LCVGLFLPHH PFLWLLRLHL
KRNADSRTEF GKYAIYCQRC VERTQQNGDR EARPSRMEIL STLLRNPYHH SLPFSIPVHF
MNGLYQVVGF DASTTVEEFL NTLNQDTGMR KPVLSGFALF TDDPAGRDLE HCLQGNIKIC
DIISKWEQAS KEQQPGKCEG TRTVRLTYKN RLYFSMQAHG ETDREKLLLM YQTNEQIING
LFPLNKDLAV EMAALLAQVE IGDFERPFST PEGHVTNQCK ANQTLKQVIE KFYPKRYRDS
FTEEQLRQLY QRLSTRWMAL RGRSGVDCVR IYLTVARKWP FFGAKLFFAK PITPPSLGNA
FMWLAINENG LSILEFNSMR LLISYAYKNL MTFGGYQDDF MVVINNLHSK DKPTEKLLFA
MAKPKILEIT LLIASYINNF HQQKAAFHHL SAPALLSVKP QEPQARAKGS QHLLPSSRPT
KGPTLL
//
