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Database: UniProt
Entry: H0VPZ0_CAVPO
LinkDB: H0VPZ0_CAVPO
Original site: H0VPZ0_CAVPO 
ID   H0VPZ0_CAVPO            Unreviewed;      1943 AA.
AC   H0VPZ0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   28-MAR-2018, entry version 49.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSCPOP00000012586};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012586};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012586};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012586}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012586};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AAKN02049254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000014109; ENSCPOP00000012586; ENSCPOG00000013968.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    158    177       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    189    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    371    398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    694    715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    802       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    863    886       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1146   1164       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1185   1201       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1213   1232       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1277   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1350   1368       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1388   1411       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1534   1553       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1589   1617       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1685   1708       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      664    890       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      900   1140       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1144   1419       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1469   1718       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1943 AA;  218874 MW;  B8061E21C963EB33 CRC64;
     MELPFGFLET TNFRRFTPES LAEIEKQIAA LKAGKKVRDK HREQKDQKEK PRPQLDLKAC
     NQLPKFYGEL PAELIGEPLE DLDPFYKAHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS WFTLFITLTI VANCVCMTRS DLPEKIEYLF TVIYTFEALI KILARGFCLN
     EFTYLRDPWN WLDFSVITLA YVGTATDLKG FSGLRTFRVL RALKTVSVIP GLKVIVGALI
     HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCVRNG TTPQQAANCS SADYTYAIKP
     GTLDPLLCGN GTGAGLCPDG YICLKTCENP DFNYTSFDSF AWAFLSLFRL MTQDSWERLY
     QQTLRASGKM YMVFFVIVIF LGSFYLVNLI LAVVTMAYEE QNQATIAEIE AKEKTFQEAL
     ERRRKEQEVL LAMGIDTASL PSRNGSPLGS KNTSERRHRM KSRASEGSTE DNKSPQSEQY
     NQRRMSFLGL TSGRRRASHG NAFHFRAPGQ DVSFPDGIAD DGVFHGDHES RQGSLLLGRG
     AGQQGSLPRS PLPQPPNPGS RHEEEGHPTL PAIELPPGAT EVLAFDAGQK KIFLSADYLN
     EPFRAQRAMS VVSIMTSVIE ELEESERKCP PCLTSLAQKY LIWECCPTWL KLKEVLFKLV
     TDPFAELTIT LCIVVNTIFM AMEHHGMSSA FESMLQIGNI VFTIFFTAEM VFKIIAFDPY
     YYFQKKWNIF DCVIVTVSLL ELSMVKKGSL SVLRTFRLLR VFKLAKSWPT LNTLIKIIGN
     SVGALGNLTI ILAIIVFIFA LVGKQLLGEA YCTKGNILPG DEPPRWHMHD FFHSFLIVFR
     ILCGEWIENM WACMQVSEKP LCLILFLTVM VLGNLVVLNL FIALLLNSFS ADNLTTPDDD
     GEVNKLQVAL GRLQVFGRQT RRALRGFFCR LCLLAGPKVE SQLTEKPPLS SSKAENHIAA
     SGSPRAPPPP RGPSAEHNDF ITNPNLWVSV PIAEGESDLD DSEDGEQDAP NSWPGTLEGL
     LPQAERCGDH LTPRSPCSGT SSEDLAPFQA SEGEEWVRAG SRPWASVLQV MDDTSSSEGS
     TVDCPDPEEI LRKIPELADD LQEPDDCFTE GCLRYCPCCN VNITKLPWAM GWQLRKTCYR
     IVEHSWFESF IIFMILLSSG SLAFEDCYLD QKPTVKALLE YTDRVFTFIF VFEMLLKWVA
     YGFKKYFTNA WCWLDFLIVN ISLVSLTAKI LEYSDVESIK ALRTLRALRP LRALSRFEGM
     RVVVDALLGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GRCINQTNGD FALVNWTVVN
     NMSECENQNY TGHLFWVNVK VNFDNVMMGY LALLQVATFK GWMDIMYAAV DSREVNSQPK
     WEDNVYMYLY FVIFIIFGGF FTLNLFVGVI IDNFNQQKKK IRGQDIFMTE EQKKYYNAMK
     KLGSKKPQKP IPRPLNKYQG FVFDIVTKQA FDISIMVLIC LNMITMMVET DDQSKEKTQV
     LGKINQFFVA VFTGECVLKM FALRHYYFTN GWNVFDLIVV LLSISSLIFS AILTSIESYF
     SPTLFRVIRL ARIGRILRLI RAAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMS
     SFPHVKEEAG IDDMFNFKTF ANSMLCLFQI TTSAGWDALL SPILNTGPPY CNGTRGDCGS
     PAVGIFFFTT YIIISFLIVV NMYIAVILEN FNAATEESTE PLSEDDFDMF YETWEKFDPE
     ATQFITFSAL SDFADTLSGP LRIPKPNRNI LIQMDLPLVP GDKIHCLDIL FAFTKKVLGE
     SGELDTLKAS MEEKFMATNL SKTSYEPIAT TLRWKQEDIS ATVIQKAYRS YVQHRSLACS
     NSSGVPRAEE EAESLPGEGF VAFMANENYA LPDKSETASA TSFPPSYDSV TRGLNDRITM
     STSSSIQNED EAMSKAVTDP GPQ
//
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