ID H0VQ75_CAVPO Unreviewed; 1305 AA.
AC H0VQ75;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Tetratricopeptide repeat domain 21A {ECO:0000313|Ensembl:ENSCPOP00000012682.3};
GN Name=TTC21A {ECO:0000313|Ensembl:ENSCPOP00000012682.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012682.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012682.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012682.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TTC21 family.
CC {ECO:0000256|ARBA:ARBA00010935}.
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DR EMBL; AAKN02049261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000012682; -.
DR Ensembl; ENSCPOT00000014221.3; ENSCPOP00000012682.3; ENSCPOG00000014079.4.
DR VEuPathDB; HostDB:ENSCPOG00000014079; -.
DR eggNOG; ENOG502QQAB; Eukaryota.
DR GeneTree; ENSGT00390000005979; -.
DR HOGENOM; CLU_006149_0_0_1; -.
DR InParanoid; H0VQ75; -.
DR OMA; QCPCLAG; -.
DR TreeFam; TF314664; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014079; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR040364; TTC21A/TTC21B.
DR PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR PANTHER; PTHR14699:SF2; TETRATRICOPEPTIDE REPEAT PROTEIN 21A; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 13.
DR SUPFAM; SSF48452; TPR-like; 5.
DR PROSITE; PS50005; TPR; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 326..359
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 494..527
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 721..754
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 755..788
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 882..915
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 949..982
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 369..396
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1305 AA; 148032 MW; B7BC43094F5D03BD CRC64;
MSSSDSSLLA GIIYYSQEKY FRHVQRAAAV GLEKFSNDPV LQFFKAYGVL REERIQDAIN
ELENVRGHPD LSLCSIIALL YAHRRCETLD REAIQELESE LKEVHRLASE TALYYAGLFL
WLIGRHDKAK EYVDHMLKVS SSSREGCVLK GWVDLTSEKP HLVKKSIKYL EQGIQSNKDV
LGLMGKATYL MMQQNYSGAL DTVNQISLAS GSFLPALILK MQLFLAQQDW EQMIETVHRI
LEKDDSNIDA CQILAVHQLM REGNVTTATD HVRNLIKALE RREPQNPSLH LKKVLVICRL
CGRHRAILQL VSNFMERIFL AVPSCAQVAT ELGYLFILQN QEKEAALWYS KAMKLGENSM
AALAGTIWCH ILKDELEEAE HQLEFLKEVQ QSLGRSEVLV FLQALLASKK HKGEQEVTAL
LQEAAELHFS NVQGLPLSPQ YLEKLDPPFL VCIAKEYLQF CPKQPRAPGQ LVSPLLKQAA
LILNPVVKAA PALIDPLYVM GQVQYLSGEL ENAQSTVQRC LELDPTSTDA HLLMAQIYLV
QGNFAMCSHC LELGVSHNFQ VRDHPLYHLI KARALNKSGD YQEAIKTLKM IMKLPTLKAE
EGRKTRRPFV QPSERVSILL ELVSALRLNG ELHEATKVMQ DAIIEFSGTT EEISITIANV
DLALSKGNVD LALSMLKDIT SKQPCYMEAK EKMASIYLQN RKDTYLYIGC YRELCEHLPG
PHTSLLLGDA FMKIQEPEKA LEVYNEAYKK NPHDASLVSR IGQAYVKTHQ YSKAINYYEA
AQKISGQDSL CCDLAELLLK LKKFNKAEKV LKQALEHDFV KDIPSMMNDV KCLLLLAKVY
KSYKREEVSE TLNKALNLQS RILKRVPLEQ PEMLPSQKQL AASICMLFGE FYWAEKDYAR
AEQSYKEALS YSPIDNKVVL ELARLSLLQG YLDSCEQHCT VLLQTDQTHE SASVMADLMF
RKQNYDAAFN LYHQVLEKAP DNFLVLDKLI DLLRRSGTLE EAPAFFQSAQ KMSSRVPMEP
GFNYCRGIYC WHIGQPNQAL KFLNKARKDI TWGQKANYYM VHICLNPDNE LVGGEAQGSA
TRKESEQQGI RTAEKLLRDF YPLSASGQTQ LRLLQSLCLL TTREKANVEA ALGAFLEIAQ
AEKDSVPALL GMAQACVLLK QIPKARTQLK RLAKAPWTLA EAEDLEKSWL LLADIYCSGG
KFDLATELLR HCIQYNKSCY KAYEYMGFIM EKEQSYKDAA TSYELAWKYS HQANPAIGFR
LAFNYLKAKK FVEAIEVCHN VLREHPSYPK IREEILEKAQ KSLRP
//
