ID H0VQR5_CAVPO Unreviewed; 712 AA.
AC H0VQR5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL10 {ECO:0000313|Ensembl:ENSCPOP00000012898.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012898.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012898.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012898.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; AAKN02001506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02001508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VQR5; -.
DR STRING; 10141.ENSCPOP00000012898; -.
DR Ensembl; ENSCPOT00000014460.3; ENSCPOP00000012898.3; ENSCPOG00000014318.4.
DR VEuPathDB; HostDB:ENSCPOG00000014318; -.
DR eggNOG; KOG2210; Eukaryota.
DR GeneTree; ENSGT00940000157880; -.
DR HOGENOM; CLU_012334_3_1_1; -.
DR InParanoid; H0VQR5; -.
DR OMA; GQHHNRT; -.
DR TreeFam; TF312807; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014318; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13291; PH_ORP10_ORP11; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF47; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10; 1.
DR Pfam; PF01237; Oxysterol_BP; 2.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 45..122
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 254..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 79892 MW; C17A46B52E3FFCCF CRC64;
RCGWDTKGEA ERSATLMSTS GLFHFFCFAV WSRLVEKNDV LSLCRYFVLD FEAGILQYFV
NEQSKHQKPR GVLSLSGAIV SMSDEAPHML VVYSASGEMY KLRAADAKER QFWVTQLRAC
AKYHMETNSK STPSSRSRSL TLLPHGTPNS ASPCSQRHLI AGAPAVVTVT HHKSPAAARR
TKSQYPGQLH EVREMMNQVE GQQKNLVHAI ESLPGSGPLT AFDQDLLLLK ATSAATLSCL
GECLSLLQHS VHQGAASSHK PGPSESILGW HGSKSHSTEQ LKNGTLGSLP SASANITWAI
LPNSTEDEQT LEPEPEPNSD PELVLSEDEK TDHEDTEETE LGVMEDQRSV ILHLISQLKL
GMDLTKVVLP TFILEKRSLL EMYADFMAHP DLLLAITAGA TPEERVICFV EYYLTAFHEG
RKGALAKKPY NPIIGETFHC SWEVPKYRVK PKRTSLAGCQ EYPAADDPSK SYKLRFIAEQ
VSHHPPISCF YCECKEKRLC INTHVWTKSK FMGMSVGVSM VGEGVLRLLE HGEEYVFTLP
SAYARSILTI PWVELGGKVS INCAKTGYSA TVTFHTKPFY GGKVHRVTAE VKHNPTNTIV
CKAHGEWNGT LEFIYSNGET KVIDTTTLPV YPKKIRPLEK QGPMESRNLW QEVTRYLRLG
DIDAATEQKR RLEEKQRIEE RKRESLRTPW QPKYFIQEGD GWVYFNPLWK TH
//
