ID H0VQV9_CAVPO Unreviewed; 3022 AA.
AC H0VQV9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 12-AUG-2020, entry version 51.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSCPOP00000012948};
GN Name=CENPF {ECO:0000313|Ensembl:ENSCPOP00000012948};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012948, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Ensembl:ENSCPOP00000012948, ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012948,
RC ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012948}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012948};
RG Ensembl;
RL Submitted (JAN-2012) to UniProtKB.
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DR EMBL; AAKN02018975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02018976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013013117.1; XM_013157663.1.
DR Ensembl; ENSCPOT00000014519; ENSCPOP00000012948; ENSCPOG00000014374.
DR GeneID; 100720167; -.
DR CTD; 1063; -.
DR GeneTree; ENSGT00730000111187; -.
DR HOGENOM; CLU_000551_0_0_1; -.
DR InParanoid; H0VQV9; -.
DR OrthoDB; 205405at2759; -.
DR TreeFam; TF101133; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014374; Expressed in uterine cervix and 5 other tissues.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 3.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1..310
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 2108..2247
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2290..2429
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2882..2925
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 213..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1702..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2801..3022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..198
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 526..618
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 654..769
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 834..854
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 863..883
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 909..960
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 972..1027
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1039..1059
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1085..1112
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1128..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1213..1247
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1289..1323
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1442..1462
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1541..1600
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1781..1829
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1881..1971
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2014..2076
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2091..2111
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2119..2174
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2189..2255
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2301..2430
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2445..2522
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2527..2623
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2645..2690
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2695..2776
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1362..1389
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2868..2883
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2911..2962
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3022 AA; 343777 MW; C0534520D3C6294C CRC64;
MSWALEEWKE GLPSRALQKI QELEVQLDKL KKEKQQRQFQ LDTLEAALQK QKQKVETEKN
EGTNLKRENQ RLMEICENLE KSKQKISHEL QVKETQVNFQ EGQLNAGKKQ IEHLEQELKR
CKSELERSQQ ATQPADVSLG SCITPQKIFA TPLTPSQHYS GSKYEDLKEK YSREVEERKR
LEVEVKALQA KVSQKASQAA PQATMNHRDI ARHQASSSVF SWQQDRTPQR LSCHSQKTPS
RRNFSSSHIF GQEEVTPSRS ILQTGKRDAN SSSCDPASGS PLLDQLKGQN QELRSKVNEL
ELRLQGQEKE MKGHAHRSQE LQLQLEKTKA ELMEKDKVLN KNRDELGRMT AQYDQAAAKC
SALEQKLKKL TEDLSCQRQN AESARCSLEQ RIKEKEKELQ EELSRQQRAF QTLEQEFVQT
KARLTQELQQ ARNALRGPEA ELDRVTAVKQ QLEKNLEEFK QKLSRMEQAS MERQEEEAAL
RRSSEEMKKE NAFLRNQSEQ RAREVSHLEE ELQKVRACLS QSQNFVEELR AKNTSQETVL
RELQEKINQQ ENSLTLEKLK LALADLEKQR DCSQDLLKKR ECHIEQLNER LSKTEKESKT
LLSALESTKK EYEALNEEKT QFSHWKSENE KLLHQMESDK EGLQSKINHL ETCLKTQQIK
SHEYNERVRT LEMERDNLGV EMRNLRNLVD SKMREVETQK QAYEELQQKA ERSDQKHKKE
IENLCLKTSQ LTAQVEDLEQ KLQRLSSELM DKDRHYQDLQ AECESLRDLL KSRDSAVPQE
DQQSSCLAFE QKAAMNTSLV NVMGEQGSNS SDRSQWLLDA DASPRSLGIL QNRVVSLESS
LESQKQMNSD LQKQCEELVY IKEEEIEENL NKAEQMHESF VAETSQRICQ LQEDTSVHQS
VITETLVALE HKEKELELWK ARLEAEQAEI QELKKSNQLL EDSLKELQLL SETLSSEKKE
MSSIISLSKK EIEELARENG TLKDMNEILN QEKINLLQKN EKFSNCIEEQ EKSISELSAQ
YKQETLILLQ RCEETGRAFE DLGEKYKAAQ EKNSRLECLL SECTSVCESR KNELEQLKET
SVKEHQEFLT KLAFAEEQNQ KLILEFEVAQ QALKSEMRDL HISSKSEADG LKQEIMTLKE
EQNKMQKEVN DLLQENQQLV KLTKTKHEDQ HLKLEPVRDS VKETEDEINA CSFQLQMDPG
DRDAAPSSYN AQLVQLEAMI RNMELKLEEC EKEKEHLQQE LQTLRGDLGA GNVHGCLPQE
MSDLTDGEVD AEGKYSLGLC ELSPRQGDNA QVQCSLQAAL SKLEELEKIC EVLQVEKLQL
VSELNNSRSE CITATSKMAG EVEKLVNEMK ILNDDSGLPR SESVEESLTS ESKGQQNEQT
PVSLMPLDDS NSYEQLTLSS KEVQTHFAEL QEKFSSLQSE HKILHDQHCQ MSSKMSELQS
YVDTLKAENS ALSMNLRNLQ VDLAKEMKPE GPILSLSFSC VTDSPSTTSV GESSFYRDAL
EHIEGASLLN HLGESVSANT SLEEERTLST KEVLTTPEKN VEELETLCQG YLQSLKNLEE
KMESQAATKD KEIQELGQLL SSERTQLDSL RKQYLSQNEE WQRKLTSVTL EMESKLAAEK
RQTEHLVLEL EVARLQLQAL ELSSQSLLGA DIEGAIEDQN DGCALKELEE NTSEITEETP
QQDNHQICEE AVRQDLHVET EVASGTLPVT PGAGERPSET SDGAAAGDKS QGCLEHTPEL
LSCDSHALVP MEFVENHVSI QHLQLQVKET VNENLRLCHA VEDQDRKVQS LLSEIKDLGA
KLESQELQLK TKIEICLQLE RIVEELQKEK CDLTERLEAF LCAGQELGPS IETSQTLSSN
LEMGTNESSE EVLEENVTKV DENWKERFLH LEDELDRIKA ENARAECRAL ALETDLEVAQ
TEKLCLEKEN ENNQKAIVRL EEELSVATSE RKHLDGELEA MKKENQTLTQ MGEIMKEKVQ
VLEAEIRDKA AGLEALSSQV SQLLEDKGDL QEWLQRLEGD SQALSSAVQE LESQVRQLEE
EKASLVREAK SLEARLRELE QERLIESRAL EVARLEKDKF AERLCSTQEE VHQLREGMEK
LRVRIEADEK RQLDVLQKLR GSERENDVLR DKVEGLQREL QMSEENQELV ILDAENAKAE
VEILRAQVEE VGESLRDSQA DLAVLRSEKG DLAKQLQEKQ GHVEELEALV SSLRSLVEEK
ERARVQMQED SKTMVETIQA QLRELTEEVA ASCEDHGTPE AREENLDTPG SEVARLRGHI
GRLRACVEAD RKEQLQVLEQ LKESQCREDL LKGRVEGLER ELELSGRDLE QAVREAENSR
AEVQTLKAEV QELSQHLRDL EADLVNIKSE KEKLTKGLRE EQAQVSELEI LNSSLEKRLQ
EKEDQKVQMR EESETAMHML QAQIKLLTER RTALSSDLEA CKIKEQTLSS QVDSLELEKA
QLLRDLETKE QTLSSQVDSL ELEKAQLLRD LETKEQTLSS RVDSLELEKA QLLQDLEEAK
HNYIVLQSSV NGLMQEAENS KQKLEEKEEE LSWLKGQVQD REQLASKLAQ VEGEQQRWQE
QKAALGTLAV ELEQKVQELQ SKNHALQDSF EVLQNSCKEL ESELTLTRGE NTSLVEKVST
LTAREAELQG KVQDMAQKTT KLEEEYSGEK TRLTEKLNAL LEEVKSSKAD HLKYVDKLKK
ENERALGKIK LLLKSCKQLE EEKKMLQKEL SQLEAAQKQN TGAALEAEVE ELTTEIRELK
EALEEKAKEA DEYLDKYCSL LISHEKLERA KEMLETQVTR LSSQPAKLDP SGSPLASLVT
PGPSAGPSAG ERKMSSGRSK AAGKRQRSSG AWESGGGLTP AALETFPKKS RKAIRSGSPH
PDQDEEEFEP EGLPEVVKKG FADIPSGKTS PYVLRRTTMA TRTSPRLAAQ KSVLSPQSVG
KENLAKSPKP TAGGSRSQKV KFRQKSPAGF AEPTVKPVSA GYPPGRSTTH SPRDGPRTRG
SLLIPTLDAR PDPPNSENCR VQ
//
