GenomeNet

Database: UniProt
Entry: H0VQV9_CAVPO
LinkDB: H0VQV9_CAVPO
Original site: H0VQV9_CAVPO 
ID   H0VQV9_CAVPO            Unreviewed;      3022 AA.
AC   H0VQV9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   12-AUG-2020, entry version 51.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSCPOP00000012948};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSCPOP00000012948};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012948, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012948, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012948,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012948}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012948};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AAKN02018975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02018976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013013117.1; XM_013157663.1.
DR   Ensembl; ENSCPOT00000014519; ENSCPOP00000012948; ENSCPOG00000014374.
DR   GeneID; 100720167; -.
DR   CTD; 1063; -.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; H0VQV9; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014374; Expressed in uterine cervix and 5 other tissues.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN          1..310
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2108..2247
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2290..2429
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2882..2925
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          213..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1353..1389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1702..1731
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2801..3022
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..198
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          526..618
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          654..769
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          834..854
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          863..883
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          909..960
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          972..1027
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1039..1059
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1085..1112
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1128..1162
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1213..1247
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1289..1323
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1442..1462
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1541..1600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1781..1829
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1881..1971
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2014..2076
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2091..2111
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2119..2174
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2189..2255
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2301..2430
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2445..2522
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2527..2623
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2645..2690
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2695..2776
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1362..1389
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2868..2883
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2911..2962
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3022 AA;  343777 MW;  C0534520D3C6294C CRC64;
     MSWALEEWKE GLPSRALQKI QELEVQLDKL KKEKQQRQFQ LDTLEAALQK QKQKVETEKN
     EGTNLKRENQ RLMEICENLE KSKQKISHEL QVKETQVNFQ EGQLNAGKKQ IEHLEQELKR
     CKSELERSQQ ATQPADVSLG SCITPQKIFA TPLTPSQHYS GSKYEDLKEK YSREVEERKR
     LEVEVKALQA KVSQKASQAA PQATMNHRDI ARHQASSSVF SWQQDRTPQR LSCHSQKTPS
     RRNFSSSHIF GQEEVTPSRS ILQTGKRDAN SSSCDPASGS PLLDQLKGQN QELRSKVNEL
     ELRLQGQEKE MKGHAHRSQE LQLQLEKTKA ELMEKDKVLN KNRDELGRMT AQYDQAAAKC
     SALEQKLKKL TEDLSCQRQN AESARCSLEQ RIKEKEKELQ EELSRQQRAF QTLEQEFVQT
     KARLTQELQQ ARNALRGPEA ELDRVTAVKQ QLEKNLEEFK QKLSRMEQAS MERQEEEAAL
     RRSSEEMKKE NAFLRNQSEQ RAREVSHLEE ELQKVRACLS QSQNFVEELR AKNTSQETVL
     RELQEKINQQ ENSLTLEKLK LALADLEKQR DCSQDLLKKR ECHIEQLNER LSKTEKESKT
     LLSALESTKK EYEALNEEKT QFSHWKSENE KLLHQMESDK EGLQSKINHL ETCLKTQQIK
     SHEYNERVRT LEMERDNLGV EMRNLRNLVD SKMREVETQK QAYEELQQKA ERSDQKHKKE
     IENLCLKTSQ LTAQVEDLEQ KLQRLSSELM DKDRHYQDLQ AECESLRDLL KSRDSAVPQE
     DQQSSCLAFE QKAAMNTSLV NVMGEQGSNS SDRSQWLLDA DASPRSLGIL QNRVVSLESS
     LESQKQMNSD LQKQCEELVY IKEEEIEENL NKAEQMHESF VAETSQRICQ LQEDTSVHQS
     VITETLVALE HKEKELELWK ARLEAEQAEI QELKKSNQLL EDSLKELQLL SETLSSEKKE
     MSSIISLSKK EIEELARENG TLKDMNEILN QEKINLLQKN EKFSNCIEEQ EKSISELSAQ
     YKQETLILLQ RCEETGRAFE DLGEKYKAAQ EKNSRLECLL SECTSVCESR KNELEQLKET
     SVKEHQEFLT KLAFAEEQNQ KLILEFEVAQ QALKSEMRDL HISSKSEADG LKQEIMTLKE
     EQNKMQKEVN DLLQENQQLV KLTKTKHEDQ HLKLEPVRDS VKETEDEINA CSFQLQMDPG
     DRDAAPSSYN AQLVQLEAMI RNMELKLEEC EKEKEHLQQE LQTLRGDLGA GNVHGCLPQE
     MSDLTDGEVD AEGKYSLGLC ELSPRQGDNA QVQCSLQAAL SKLEELEKIC EVLQVEKLQL
     VSELNNSRSE CITATSKMAG EVEKLVNEMK ILNDDSGLPR SESVEESLTS ESKGQQNEQT
     PVSLMPLDDS NSYEQLTLSS KEVQTHFAEL QEKFSSLQSE HKILHDQHCQ MSSKMSELQS
     YVDTLKAENS ALSMNLRNLQ VDLAKEMKPE GPILSLSFSC VTDSPSTTSV GESSFYRDAL
     EHIEGASLLN HLGESVSANT SLEEERTLST KEVLTTPEKN VEELETLCQG YLQSLKNLEE
     KMESQAATKD KEIQELGQLL SSERTQLDSL RKQYLSQNEE WQRKLTSVTL EMESKLAAEK
     RQTEHLVLEL EVARLQLQAL ELSSQSLLGA DIEGAIEDQN DGCALKELEE NTSEITEETP
     QQDNHQICEE AVRQDLHVET EVASGTLPVT PGAGERPSET SDGAAAGDKS QGCLEHTPEL
     LSCDSHALVP MEFVENHVSI QHLQLQVKET VNENLRLCHA VEDQDRKVQS LLSEIKDLGA
     KLESQELQLK TKIEICLQLE RIVEELQKEK CDLTERLEAF LCAGQELGPS IETSQTLSSN
     LEMGTNESSE EVLEENVTKV DENWKERFLH LEDELDRIKA ENARAECRAL ALETDLEVAQ
     TEKLCLEKEN ENNQKAIVRL EEELSVATSE RKHLDGELEA MKKENQTLTQ MGEIMKEKVQ
     VLEAEIRDKA AGLEALSSQV SQLLEDKGDL QEWLQRLEGD SQALSSAVQE LESQVRQLEE
     EKASLVREAK SLEARLRELE QERLIESRAL EVARLEKDKF AERLCSTQEE VHQLREGMEK
     LRVRIEADEK RQLDVLQKLR GSERENDVLR DKVEGLQREL QMSEENQELV ILDAENAKAE
     VEILRAQVEE VGESLRDSQA DLAVLRSEKG DLAKQLQEKQ GHVEELEALV SSLRSLVEEK
     ERARVQMQED SKTMVETIQA QLRELTEEVA ASCEDHGTPE AREENLDTPG SEVARLRGHI
     GRLRACVEAD RKEQLQVLEQ LKESQCREDL LKGRVEGLER ELELSGRDLE QAVREAENSR
     AEVQTLKAEV QELSQHLRDL EADLVNIKSE KEKLTKGLRE EQAQVSELEI LNSSLEKRLQ
     EKEDQKVQMR EESETAMHML QAQIKLLTER RTALSSDLEA CKIKEQTLSS QVDSLELEKA
     QLLRDLETKE QTLSSQVDSL ELEKAQLLRD LETKEQTLSS RVDSLELEKA QLLQDLEEAK
     HNYIVLQSSV NGLMQEAENS KQKLEEKEEE LSWLKGQVQD REQLASKLAQ VEGEQQRWQE
     QKAALGTLAV ELEQKVQELQ SKNHALQDSF EVLQNSCKEL ESELTLTRGE NTSLVEKVST
     LTAREAELQG KVQDMAQKTT KLEEEYSGEK TRLTEKLNAL LEEVKSSKAD HLKYVDKLKK
     ENERALGKIK LLLKSCKQLE EEKKMLQKEL SQLEAAQKQN TGAALEAEVE ELTTEIRELK
     EALEEKAKEA DEYLDKYCSL LISHEKLERA KEMLETQVTR LSSQPAKLDP SGSPLASLVT
     PGPSAGPSAG ERKMSSGRSK AAGKRQRSSG AWESGGGLTP AALETFPKKS RKAIRSGSPH
     PDQDEEEFEP EGLPEVVKKG FADIPSGKTS PYVLRRTTMA TRTSPRLAAQ KSVLSPQSVG
     KENLAKSPKP TAGGSRSQKV KFRQKSPAGF AEPTVKPVSA GYPPGRSTTH SPRDGPRTRG
     SLLIPTLDAR PDPPNSENCR VQ
//
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