ID H0VRL5_CAVPO Unreviewed; 475 AA.
AC H0VRL5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=WH2 domain-containing protein {ECO:0000259|PROSITE:PS51082};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013232.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013232.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013232.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02016013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VRL5; -.
DR STRING; 10141.ENSCPOP00000013232; -.
DR Ensembl; ENSCPOT00000014829.3; ENSCPOP00000013232.3; ENSCPOG00000014684.4.
DR VEuPathDB; HostDB:ENSCPOG00000014684; -.
DR eggNOG; ENOG502QPSI; Eukaryota.
DR GeneTree; ENSGT00510000046704; -.
DR HOGENOM; CLU_012316_1_0_1; -.
DR InParanoid; H0VRL5; -.
DR OMA; IQFYEIQ; -.
DR TreeFam; TF331023; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014684; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR Gene3D; 6.10.280.150; -; 1.
DR InterPro; IPR031738; JMY/WHAMM.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR23330; P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED; 1.
DR PANTHER; PTHR23330:SF6; WASP HOMOLOG-ASSOCIATED PROTEIN WITH ACTIN, MEMBRANES AND MICROTUBULES; 1.
DR Pfam; PF15871; JMY; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 411..427
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 295..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 55067 MW; 5F6F4CA1B6331251 CRC64;
MVALMELYEK EDEVYRELVL AATKFFQFLL TPLRNKREHA TSRRLNILKS LDNDNLGPQR
VATLQMEAQM WASEAEEAVA TIQDTTVDYF KETVKALTEM QKQMEADSKR FGQAAWASAT
PRLENLKLMV AKETLQLMRA KELCLNHKKA AIERKMEDLP GQDKKNICII DELEIQCYEI
QLEIYEIKFE ILKNEEILLI TKLDSVKRLI KEKQDEVVYY DTCESPEEIQ GLSCHVAAQD
VEIAEMRALS LRRRQLEKKR GKISAKRAQL RNKTDQCKAN HHLRLQQAEK SVRHLHEHHS
IQMKRDKIKE EEQKKKEWVN QERQKTLRRL RAYKEVSSTN NHLNFFLSQT DTHRNPGPRA
SVDDDQPRSL MCVSPPEGSM DEVLASLRHD RTRLQKTENR SALSPSRASV NEDILMAIRQ
GVKLKKVPQN PGSGPSTRPA SDLERSIKAA LQRIKQVSAD SEEDSDEQNH DQWNH
//
