ID H0VSM2_CAVPO Unreviewed; 405 AA.
AC H0VSM2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=CWC25 spliceosome associated protein homolog {ECO:0000313|Ensembl:ENSCPOP00000013636.3};
GN Name=CWC25 {ECO:0000313|Ensembl:ENSCPOP00000013636.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013636.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013636.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013636.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CWC25 family.
CC {ECO:0000256|ARBA:ARBA00006695}.
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DR EMBL; AAKN02042377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VSM2; -.
DR STRING; 10141.ENSCPOP00000013636; -.
DR Ensembl; ENSCPOT00000015274.3; ENSCPOP00000013636.3; ENSCPOG00000015127.4.
DR VEuPathDB; HostDB:ENSCPOG00000015127; -.
DR GeneTree; ENSGT00440000039055; -.
DR HOGENOM; CLU_025093_1_0_1; -.
DR InParanoid; H0VSM2; -.
DR OMA; SWHPHTM; -.
DR TreeFam; TF320801; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015127; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:Ensembl.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR InterPro; IPR019339; CIR_N_dom.
DR InterPro; IPR022209; CWC25.
DR PANTHER; PTHR16196; CELL CYCLE CONTROL PROTEIN CWF25; 1.
DR PANTHER; PTHR16196:SF0; PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG; 1.
DR Pfam; PF10197; Cir_N; 1.
DR Pfam; PF12542; CWC25; 1.
DR SMART; SM01083; Cir_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 11..47
FT /note="CBF1-interacting co-repressor CIR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01083"
FT REGION 145..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 23..66
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 145..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..194
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 47335 MW; BB67DE5948D7B7E8 CRC64;
MGGGDLNLKK SWHPQTLRNV EKVWKAEQKH EAERKKIEEL QRELREERAR EEMQRYAEDV
GAVKKKEEKL DWMYQGPGGM VNRDEYLLGR PIDKYVFEKA EDKEAGCSSE TGLLPGSIFA
PAGANSLLDM ASKIREDPLF LIRKKEEEKK REVLNNPVKM KKIRELLQMS LEKKEKKKKK
EKKKKHKKHK HRSSSSTRSS SEDEPSRGRA QKKATDSFPV LSKVPGYGLQ VRDPARGQRP
RARLGNDRSR SPSSSRSPSR HASRRNPKDR SPRDRSPRSP HNGKGSHRER APTQSPSPSL
KKACLQRRMP GYTRKLSPEE LERKRQEMLQ NARWREEERL DALRRHARED EREHRLEQLD
SRDGRFIHRM KLESAATSSL EDRVKRNIHS LQRTSAALER NFMRR
//
