ID H0VSU3_CAVPO Unreviewed; 1317 AA.
AC H0VSU3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Pogo transposable element derived with ZNF domain {ECO:0000313|Ensembl:ENSCPOP00000013711.3};
GN Name=POGZ {ECO:0000313|Ensembl:ENSCPOP00000013711.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013711.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013711.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013711.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02003945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000015357.3; ENSCPOP00000013711.3; ENSCPOG00000015210.4.
DR VEuPathDB; HostDB:ENSCPOG00000015210; -.
DR GeneTree; ENSGT00940000160649; -.
DR HOGENOM; CLU_002015_0_0_1; -.
DR TreeFam; TF331707; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015210; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24403:SF59; POGO TRANSPOSABLE ELEMENT WITH ZNF DOMAIN; 1.
DR PANTHER; PTHR24403; ZINC FINGER PROTEIN; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 398..425
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 434..462
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 919..989
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000259|PROSITE:PS51253"
FT REGION 143..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..832
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1317
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1317 AA; 145646 MW; 43F5746B9F0738FC CRC64;
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQQVS APVPIAAHAS
VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAPGTQF VKPTVGVPQV FSQMTPVRPG
STMPVRPTTN TFTTVIPATL TIRSTVPQSQ SQQTKSTPST STTPTATQPT SLGQLAVQPP
GQSNQTSNPK LAPSFPSPPA VSIASFVTVK RPGVTGENNN EVAKLVNTLN TIPSLGQSPG
PIVVSNNSSA HGAQRTSGPE SSLKVTSSLP VFDLQDGGRK ICPRCNAQFR VTEALRGHMC
YCCPEMVEYQ KKGKSLDSEP GVPSAAKPSS PEKTAPVTST PSTPIPALSP PTKVPEPNEN
VGDAVQTKLI MLVDDFYYGR DSGKASQLTN FPKVATSFRC PHCTKRLKNN IRFMNHMKHH
VELDQQNGEV DGHTICQHCY RQFSTPFQLQ CHLENVHSPY ESTTKCKICE WAFESEPLFL
QHMKDTHKPG EMPYVCQVCQ YRSSLYSEVD VHFRMVHEDT RHLLCPYCLK VFKNGNAFQQ
HYMRHQKRNV YHCNKCRLQF LFAKDKIEHK LQHHKTFRKP KQLEGLKPGT KVTIRASRGQ
PRTVPVSSSD TPPSAVQEAA PLTSSADPLP VFLYPPVQRN IQKRAVRKMS VMGRQTCLEC
SFEIPDFPNH FPTYVHCSLC RYSTCCSRAY ANHMINNHVP RKSPKYLALF KNSVSGIKLA
CTSCTFVTSV GDAMAKHLVF NPSHRSSSIL PRGFTWMSHS RHGQARDRGH DRNLKNMCSI
SSFTPTKAAT TKPVGATPAE SEELPASMAQ ALPSPASTAT PPPTPTQPQP LALPPLATEV
AECLNVDDQD EGSPLTQEPE PASGGGGSSE VGKKEQLSVK KLRVVLFALC CNTEQAAEHF
RNPQRRIRRW LRRFQASQGE NLEGKYLSFE AEEKLAEWVL TQREQQLPVN EETLFQKATK
IGRSLEGGFK ISYEWAVRFM LRHHLTPHAR RAVAHTLPKD VAENAGLFIE FVQRQIHNQD
LPLSMIVAID EVSLFLDTEV LSSDDRKENA LQTVGTGESW CDVVLAILAD GTILPTLVFY
RGQINQPANV PDSILLEAKE SGYSDDEIME LWSTRVWQKH TTCQRGKGML VMDCHRTHLS
EEVLAMLSAS STLPAVVPAG CSSKIQPLDV CIKRTVKNFL HKKWKEQARE MADNACDSDV
LLQLVLVWLG EVLSVIRDCP ELVQRSFLVA SVLPGPDGNI NSPTRNADMQ EELIASLEEQ
LKLSGEQSEE PSASTPRPRS SPEETVEPES LHQLFEGESE TESFYGFEEA DLDLMEI
//
