ID H0VTE8_CAVPO Unreviewed; 629 AA.
AC H0VTE8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=EF-hand calcium binding domain 7 {ECO:0000313|Ensembl:ENSCPOP00000013939.3};
GN Name=EFCAB7 {ECO:0000313|Ensembl:ENSCPOP00000013939.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013939.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013939.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013939.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02005151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479171.1; XM_003479123.3.
DR AlphaFoldDB; H0VTE8; -.
DR STRING; 10141.ENSCPOP00000013939; -.
DR Ensembl; ENSCPOT00000015609.3; ENSCPOP00000013939.3; ENSCPOG00000015458.4.
DR GeneID; 100728294; -.
DR KEGG; cpoc:100728294; -.
DR CTD; 84455; -.
DR VEuPathDB; HostDB:ENSCPOG00000015458; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00390000015466; -.
DR HOGENOM; CLU_031520_1_0_1; -.
DR InParanoid; H0VTE8; -.
DR OMA; KTIDKYW; -.
DR OrthoDB; 23056at2759; -.
DR TreeFam; TF329354; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015458; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:1903569; P:positive regulation of protein localization to ciliary membrane; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46819; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7; 1.
DR PANTHER; PTHR46819:SF1; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 102..137
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 402..437
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 190..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 71576 MW; 467978524FECF27B CRC64;
MATSPGSDIA FASQKSMPSE NLRTKKLPLS EEEVFYMNCR AVYLTVFKSS LENIISKDQL
YLALQHAGRN PSQKTIDKYW TPQTAKLNFD DFCVILRKEK PTSKAELLKS FKQLDVNDDG
YILHTDLYKF LTKRGEKMTP EEVNTIINLP NINADGKFDY IKFCKLYMTT SGQCLKTALE
RLQVDSKQRR QQFGSHMEEL PARDPSSVLK PSPRILRNSD QETLSNRGDP RASLLSTARK
FKASVTCTIS MAANGNQNAK LTEPNLKDWP GVQSRGCFFL EDDGETVSHQ YRLHMAQRST
VHLTIKPLNL SQVEGKLSPW SSVDTALYIL KENEDQVDPQ LVCFTDLQHR EGFGWTGELT
PGLYRLLPST SGCRLRKERT PEPEEAQLVC RDDAGDLFLT QAFKAALSDV FDVIDLDGNG
FLSLEEYNFF ELRTSGEKCG EEAWLLCREH FDTKKNELTR QGFMDLHLME ANDREGDPCD
LWVTLRAMGY NRALELKEAC PFVIDLHAER CKPRLKAVRM EASRGQLEKA TCQSVLLQGE
ARAMDGYENV LVHTRSWDFR ITSVIENKSD NKVIIHINNE LSKNCVNNRG LNVFAVEVAP
QSSMVCQHVM PLNEHQEWVH HCVYSLISS
//
