ID H0VTR6_CAVPO Unreviewed; 546 AA.
AC H0VTR6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Oncoprotein induced transcript 3 {ECO:0000313|Ensembl:ENSCPOP00000014075.3};
GN Name=OIT3 {ECO:0000313|Ensembl:ENSCPOP00000014075.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014075.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014075.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014075.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02021259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02021260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VTR6; -.
DR STRING; 10141.ENSCPOP00000014075; -.
DR Ensembl; ENSCPOT00000015760.3; ENSCPOP00000014075.3; ENSCPOG00000015607.4.
DR VEuPathDB; HostDB:ENSCPOG00000015607; -.
DR eggNOG; ENOG502QW18; Eukaryota.
DR GeneTree; ENSGT00940000157851; -.
DR HOGENOM; CLU_037129_2_0_1; -.
DR InParanoid; H0VTR6; -.
DR OMA; GPQSQML; -.
DR TreeFam; TF330284; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015607; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003014; P:renal system process; IEA:Ensembl.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF18; ONCOPROTEIN-INDUCED TRANSCRIPT 3 PROTEIN; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..546
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011482941"
FT DOMAIN 261..516
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
SQ SEQUENCE 546 AA; 60006 MW; 8A54B335ED1AAF6F CRC64;
MPQSLLLTGL FILVTPVSPM ALDPCSAYIS LNEPWRNTDH QFDESQGTPL CDNHMDGEWY
RFTGMAGDAM PTFCVPENHC GTHAPIWLNG SQPLESDGIV QRQACTSFKG NCCLWDTTVE
VKACPGGYYV YRLSKPSVCF HVYCGHFYDI CDEDCHGSCL GTSQCTCSPG TVLGPDGQTC
FDENECEQDN GGCSEICVNL KHSYRCECGV GRVLRSDGKT CEDIKGCHNN NGGCSHSCLG
SEKGYQCECP RGLVLADDNH TCQVPVVCKS NAIEVNVPRE LVGGLELFLT NTSCRGVSNG
THVNIFFSLK TCGTVVNVVN DKIVASNLVT GLPKQTPGSS GDIIVRTSEL LIPVTCEFPR
LYTISEGYVP NLRSSPLEIL GRSHGVFPFT LEIFKDHEFE EPYREALPSL KLRDSLFFGI
EPLVHVSGLE SLVESCFATP TSKVDEILKY YLIRDGCVSD DSVKQYSSRD HLAKHFQVPV
FKFVGKDHKE VFLHCRVLVC GMLDTRSRCA QGCHQRVRRA AGEGENTAGL QSQILTGGPI
SIDWEH
//
