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Database: UniProt
Entry: H0VTW5_CAVPO
LinkDB: H0VTW5_CAVPO
Original site: H0VTW5_CAVPO 
ID   H0VTW5_CAVPO            Unreviewed;      4554 AA.
AC   H0VTW5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSCPOP00000014131};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSCPOP00000014131};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014131};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000014131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014131};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000014131}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014131};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AAKN02042203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02042204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02042205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02042206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000014131; -.
DR   Ensembl; ENSCPOT00000015824; ENSCPOP00000014131; ENSCPOG00000015669.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155288; -.
DR   InParanoid; H0VTW5; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000015669; Expressed in 2 organ(s), highest expression level in brain.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4165   4188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4354   4376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4435   4458       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1356   1569       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     2647   2667       {ECO:0000256|SAM:Coils}.
FT   COILED     3105   3125       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4554 AA;  514030 MW;  E504AB7DD2CA94DC CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSGMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTT HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSCCE EGYVTGGHVL RLFHGHMDEC LTISPADSDD
     QRRLVYYEGG SVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
     VVDASKAHTK ATSFCFRVSK EKLDMAPKRD VEGMGPPEIK YGESLCFVQH MASGLWLTYA
     APDPKALRLG VLKKKAMLHQ EGHMDDALSL TRCQHEESQA ARMIHSTAGL YNQFIKGLDS
     FSGKPRGSGP PAGSALPIES VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
     EGMLTLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYELLASLI RGNRANCALF
     STNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGTTQYG
     KWYFEVMVDE VDPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWTGHVARPV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLDGLFFPV
     VSFSAGIKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LHLEPIKEYR REGPRGPHLV
     GPSRCLSHTD FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGPVRDDN
     KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTYM
     MSNGYKPAPL DLSHVRLTPA QTTLVDRLAE NGHNVWARDR VGQGWSYSAV QDIPARRNPR
     LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVENQSRWD RVRIFRAEKS
     YAVQSGRWYF EFEAVTTGEM RVGWARPELR PDVELGADDL AYVFQWGQRW HLGSEPFGRP
     WQSGDVVGCM IDLTENTIIF TLNGEVLMSD SGSETAFREI EIGDGFLPVC SLGPGQVGHL
     NLGQDVSSLR FFAICGLQEG FEPFAINMQR PVTTWFSKSL PQFEPVPFDH PHYEVARMDG
     TVDTPPCLRL THRTWSSQNS LVEMLFLRLS LPVQFHQHFR CTAGATPLAP PGLQPPAEDE
     ARAAEPDPDY ENLRRSAGGW GEAEGGKEGT AKEGAPGGTL QAGVEAQPAR AENEKDATTE
     KNKKRGFLFK AKKAAMMTQP PATPTLPRLP HDVVPTDDRD DPEIILNTTT YYYSVRVFAG
     QEPSCVWVGW VTPDYHQHDM NFDLSKVRAV TVTMGDEQGN VHSSLKCSNC YMVWGGDFVS
     PGQQGRISHT DLIIGCLVDL ATGLMTFTAN GKESNTFFQV EPNTKLFPAV FVLPTNQNVI
     QFELGKQKNI MPLSAAMFVS ERKNPAPQCP PRDWRCGHTR AASAWMAVQC QEPLTMMALH
     IPEKNKVRAC LMASGQDAVT LWVRIEAQCL LIPQDTAREP LDTSQGPSSS QGMCHLLEYF
     CDQELQHRVE SLAAFAERYV DKLQANQRDR YSLLMKAFTM SAAETARRTR EFRSPPQEQI
     NMLLQFKDGA DEEDCPLPEE IRADLQDFHQ DLLAHCGIQL EGEEEEPEEE TTLGSRLMSL
     LEKVRLVKKK EEKPEEETPA EEPKPRSLQE LVSQMVVRWA QEDFVQSPEL VRAMFSLLHR
     QYDGLGELLR ALPRAYTISP SSVDDTMSLL ECLGQIRSLL IVQMGPQEEN LMIQSIGNIM
     NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEIRFP KMVTSCCRFL CYFCRISRQN
     QRSMFDHLSY LLENSGIGLG MQGSTPLDVA AASVIDNNEL ALALQEQDLE KVVSYLAGCG
     LQSCSMLLAK GYPDIGWNPC GGERYLDFLR FAVFVNGESV EENANVVVRL LIRKPECFGP
     ALRGEGGSGL LAAIEEAIRI SEDPARDGPG VRRDRRREHF GEEAPEENRV HLGHAIMSFY
     AALIDLLGRC APEMHLIQAG KGEALRIRAI LRSLVPLDDL VGIISLPLQI PTLGKDGALI
     QPKMSASFVP DHKASMVLFL DRVYGIENQD FLLHVLDVGF LPDMRAAASL DTATFSTTEM
     ALALNRYLCL AVLPLITKCA PLFAGTEHRA IMVDSMLHTV YRLSRGRSLT KAQRDVIEDC
     LMALCRYIRP SMLQHLLRRL VFDVPILNEF AKMPLKLLTN HYERCWKYYC LPTGWANFGV
     TSEEELHLTR KLFWGIFESL AHKKYDQELY RMAMPCLCAI AGALPPDYVD ASYSSKAEKK
     ATVDAEGNFD PRPVETLNVI IPEKLDSFIN KFAEYTHEKW AFDKIQNNWS YGDNIDEELK
     THPMLRPYKT FSEKDKEIYR WPIKESLKAM IAWEWTIEKA REGEEEKTEK KKTRKISQTA
     QTYDPREGYN PQPPDLSGVT LSRELQAMAE QLAENYHNTW GRKKKQELEA KGGGSHPLLV
     PYDTLTAKEK ARDREKAQEL LKFLQMNGYA VTRGLKDMEL DTSSIEKRFA FGFLQQLLRW
     MDISQEFIAH LEAVVSSGRV EKSPHEQEIK FFAKILLPLI NQYFTNHCLY FLSTPAKVLG
     SGGHASNKEK EMITSLFCKL AALVRHRVSL FGTDAPAVVN CLHILARSLD ARTVMKSGPE
     IVKAGLRSFF ESASEDIEKM VENLRLGKVS QARTQVKGVG QNLTYTTVAL LPVLTTLFQH
     IAQHQFGDDV ILDDVQVSCY RTLCSIYSLG TTRNPYVEKL RPALGECLAR LAAAMPVAFL
     EPQLNEYNAC SVYTTKSPRE RAILGLPNSV EEMCPDIPVL ERLMADIGGL AESGARYTEM
     PHVIEITLPM LCSYLPRWWE RGPEAPPPAL PAGAPPPCTA VTSDHLNSLL GNILRIIVNN
     LGIDEASWMK RLAVFAQPIV SRARPELLRS HFIPTIGRLR KRAGKVVAEE EQLRLEAKAE
     AEEGELLVRD EFSVLCRDLY ALYPLLIRYV DNNRAQWLTE PNPNAEELFR MVGEIFIYWS
     KSHNFKREEQ NFVVQNEINN MSFLTADSKS KMAKVGSGGS DQERTKKKRR GDRYSVQTSL
     IVATLKKMLP IGLNMCAPTD QELITLAKGR YALKDTDEEV REFLQNNLNL QGKVEGSPSL
     RWQMALYWGV PGREEDADNP EKIVRRVQEV SAVLYHLDQT EHPYKSKKAV WHKLLSKQRR
     RAVVACFRMT PLYNLPTHRA CNMFLESYKA GWLLSEDHSF EDRMIDDLSK AGEQDEEEEE
     VEEKKPDPLH QLVLHFSRTA LTEKSKLDED YLYIAYADIM AKSCHLEEGG ENGEAQEEEV
     EVSFEEKEME KQRLLYQQSR LHNRGAAEMV LQMISACKGE TGTMVSSTLK LGISILNGGN
     ADVQQKMLDY LKDKKEVGFF QSIQALMQTC SVLDLNAFER QNKAEGLGMV NEDGTVINRQ
     NGEKVMADDE FTQDLFRFLQ LLCEGHNNDF QNYLRTQTGN TTTINIIICT VDYLLRLQES
     ISDFYWYYSG KDVIEEQGKR NFSKAMSVAK QVFNSLTEYI QGPCTGNQQS LAHSRLWDAV
     VGFLHVFAHM MMKLAQDSSQ IELLKELLDL QKDMVVMLLS LLEGNVVNGM IARQMVDMLV
     ESSSNVEMIL KFFDMFLKLK DIVGSEAFQD YVTDPRGLIS KKDFQKAMDS QKQFTGPEIQ
     FLLSCSEADE NEMINCEEFA NRFQEPAREI GFNVAVLLTN LSEHVPHDPR LRNFLELAES
     ILDYFRPYLG RIEIMGASRR IERVYFEISE TNRAQWEMPQ VKESKRQFIF DVVNEGGEAE
     KMELFVSFCE DTIFEMQIAA QISEPEGEPE EDEDEGARGA VTVVVEEEGQ PQRLSHVPYS
     QVDGEEEELP PEPEPEPEPE KADAENGEKE EKEEAGGAGM EFWGELEFLN YLSRNFYTLR
     FLALFLAFAI NFILLFYKVS DSPPGEDDME GSAAGDMSGA GSGGGSGWGS GAGEEAEGDE
     DENMVYYFLE ESTGYMEPAL RCLSLLHTLV AFLCIIGYNC LKVPLVIFKR EKELARKLEF
     DGLYITEQPE DDDVKGQWDR LVLNTPSFPS NYWDKFVKRK VLDKHGDIYG RERIAELLGM
     DLATLEITAH NERKPDPPPG LLTWLMSIDV KYQIWKFGVI FTDNSFLYLG WYMVMSLLGH
     YNNFFFAAHL LDIAMGVKTL RTILSSVTHN GKQLVMTVGL LAVVVYLYTV VAFNFFRKFY
     NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED PAGDEYELYR VVFDITFFFF
     VIVILLAIIQ GLIIDAFGEL RDQQEQVKED METKCFICGI GSDYFDSTPH GFETHTLEEH
     NLANYMFFLM YLINKDETEH TGQESYVWKM YQERCWDFFP AGDCFRKQYE DQLS
//
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