ID H0VU20_CAVPO Unreviewed; 1281 AA.
AC H0VU20;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN Name=NPHP3 {ECO:0000313|Ensembl:ENSCPOP00000014191.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014191.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014191.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014191.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02013012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02013013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000014191; -.
DR Ensembl; ENSCPOT00000015892.3; ENSCPOP00000014191.3; ENSCPOG00000015737.4.
DR VEuPathDB; HostDB:ENSCPOG00000015737; -.
DR eggNOG; KOG1840; Eukaryota.
DR GeneTree; ENSGT00940000156398; -.
DR HOGENOM; CLU_007418_0_0_1; -.
DR InParanoid; H0VU20; -.
DR OMA; FKIHQKA; -.
DR TreeFam; TF314010; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015737; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0097543; C:ciliary inversin compartment; IEA:Ensembl.
DR GO; GO:0003283; P:atrial septum development; IEA:Ensembl.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0071908; P:determination of intestine left/right asymmetry; IEA:Ensembl.
DR GO; GO:0071910; P:determination of liver left/right asymmetry; IEA:Ensembl.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IEA:Ensembl.
DR GO; GO:0071909; P:determination of stomach left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060993; P:kidney morphogenesis; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0048496; P:maintenance of animal organ identity; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; IEA:Ensembl.
DR GO; GO:0072189; P:ureter development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 936..969
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1044..1077
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1086..1119
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1128..1161
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1170..1203
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1212..1245
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1249..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..179
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1253..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1281 AA; 145872 MW; E98F468D4EC4EB22 CRC64;
MGTASSLVSP AGGEACEIPV EVKPKARLLR SSFRRGAGAA AGTGPGSLPR AAGGAGLLGL
EYAAAEYERL KKEYEIFRVS KNQELLSMGR REAKLDTENK RLRAELQALQ KTYQKILREK
ESALEAKYQA MERAATFEHD RDKVKRQFKI FRETKENEIQ DLLRAKRELE SKLQRLQAQG
IQVFDPGESD SDDNCTDVTA SGTQCEYWAG GALGSEPSLG SMIQLQQSFR GPEFAHSSVD
VEGPFANVNR DDWDIAVASL LQVTPLFSHS LWSNTVRCYL MYTDETQPEM DLFLKDYSPK
LKRMCETMGY FFHAVYFPVD VENQYLTIRK WEIEKSSLVI LFIHSTLPSS DSVQQLIDQV
CNLSKAHKAK IIDHSGDPAE GVYKTYICVE KIIKQDILGF ENTDLESKDL GAEEPIPEED
DFGDVLWDIH DEQEQMEAFQ QASNSAHELG FEKYYQRLND LVAAPAPIPP LLVSGGPGSG
KSLLLSKWIQ LQQKSSPNML ILSHFVGRPM STSSESSLII KRLTLKLMQH SWSVSTLTLD
PAKLLEEFPH WLEKLSARHQ GSIIIIIDSI DQVQQVEKHM KWLIDPLPVN VRVIVSVNVE
TCPAAWRYAS WDRTKHLKGK QGKVSINILT ASLQRCLYFV MFCELVQEKK LEQHCRCPAT
CNALYVTLFG KMMARAGKRG NLDKILHQCL QCQDTVALYR LVLHSIQESM ASDVEKELMR
QVLCLINVSH NGLSESELME LYPETPWAIL TSLIYSLYSM CLLTYGCGLL RFQHLQAWET
VRLEYMNDPT VISSYRQKLI SYFTLQLSQD RVTWRSADEL PWLFQQQGGR QKLHDCLLNL
FVSQNLYKRG HFAELLSYWQ FVGKDKSAMA TEYFDSLKQY EKNCEGEENM ICLADLYETL
GRFLKDLGLL SQAVVPLQRS LEIRETALDP DHPRVAQSLH QLASVYVQWK KFGNAEQLYK
QALEISENAY GADHPHTARE LEALATLYQK QNKYEQAEHF RKKSFKIRQK ATRKKGNLYG
FALLRRRALQ LEELTLGKDT PENARTLNEL GVLYYLQNSL ETADQFLKRS LEMRERVLGA
NHPDCAQSLN NLAALYHEKK QYDKAEELYE RALDIRRRAL APDHPSLAYT VKHLAILYKK
MGKFDKAVPL YELAVEIRQK SFGQKHPSVA TALVNLAVLY SQMKKYNEAL PLYERALKIY
EDSLGQMHPR VGETLKNLAV LSYEEGDFEK AAELYKRAME IKEAEMSLLG GKAPSRHSSS
GDTLSLKTTH SPNVFLPQGQ R
//
