ID H0VU24_CAVPO Unreviewed; 953 AA.
AC H0VU24;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Thyroid hormone receptor associated protein 3 {ECO:0000313|Ensembl:ENSCPOP00000014195.3};
GN Name=THRAP3 {ECO:0000313|Ensembl:ENSCPOP00000014195.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014195.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014195.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014195.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BCLAF1/THRAP3 family.
CC {ECO:0000256|ARBA:ARBA00006481}.
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DR EMBL; AAKN02028512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003471366.1; XM_003471318.3.
DR RefSeq; XP_005004267.1; XM_005004210.2.
DR AlphaFoldDB; H0VU24; -.
DR STRING; 10141.ENSCPOP00000014195; -.
DR Ensembl; ENSCPOT00000015897.3; ENSCPOP00000014195.3; ENSCPOG00000015742.4.
DR GeneID; 100733607; -.
DR KEGG; cpoc:100733607; -.
DR CTD; 9967; -.
DR VEuPathDB; HostDB:ENSCPOG00000015742; -.
DR eggNOG; ENOG502QR38; Eukaryota.
DR GeneTree; ENSGT00950000183163; -.
DR HOGENOM; CLU_014485_1_0_1; -.
DR InParanoid; H0VU24; -.
DR OMA; SHSYKVE; -.
DR OrthoDB; 5323286at2759; -.
DR TreeFam; TF335939; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015742; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0035145; C:exon-exon junction complex; IEA:Ensembl.
DR GO; GO:0016592; C:mediator complex; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:Ensembl.
DR GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0048255; P:mRNA stabilization; IEA:Ensembl.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0042753; P:positive regulation of circadian rhythm; IEA:Ensembl.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR InterPro; IPR029199; THRAP3_BCLAF1.
DR PANTHER; PTHR15268; THRAP3/BCLAF1; 1.
DR PANTHER; PTHR15268:SF16; THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF15440; THRAP3_BCLAF1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..49
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..139
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..775
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 108428 MW; DF6E292BA7348262 CRC64;
MSKTNKSKSG SRSSRSRSAS RSRSRSFSKS RSRSRSVSRS RKRRLSSRSR SRSYSPAHNR
ERNHPRVYQN RDFRGHNRGY RRPYYFRGRN RGFYPWGQYN RGGYGNYRSN WQNYRQAYSP
RRGRSRSRSP KRRSPSPRSR SHSRNSDKSS SDRSRRSSSS RSSSNHSRVE SSKRKSAKEK
KSSSKDSRPS QATGDNQGDE AKEQTFSGGT SQDTKTSESS KPWPDATTYS TGSASRASAV
SDLSPRERSP ALKSPLQSVV VRRRSPRPSP VPKPSPPLSS TSQMGSSLPS GTGYQSGSHQ
SQFDHGSGSL SPSKKSPVGK SPPASGSTYG SSQKEESAAS GGAAYTKRYL EDQKTENGKD
KEQKQTNSDK EKGKEKGSFS DVDAKVKSDS FVSKTDTEKP FRGSQSPKRY KLRDDFEKKM
ADFHKEEMDD QDKDKPKGRK ESEFDDEPKF MSKVIAGASK SQEEEKSGKW EGLVYSGKEK
QRKAEELEEE SFTERSKKEE RGGAKRSESG HRGFVPEKNF RVTAYKAVQE KSSSPPPRKT
SESREKLGGK GDFSSGKSSF SITREAQVNV RMDSFDEDLA RPSGLLAQER KLCRDLVHSN
KKEQEFRSIF QHIQSAQSQR SPSELFAQHI VTIVHHVKEH HFGSSGMTLH ERFTKYLKRG
AEQEAAKNKK SPEIHRRIDI SPSTFRKHGL AHDEMKSPRE PGYKAEGKYK DDPVDLRLDI
ERRKKHKERD LKRGKSRESV DSRDSSHSRE RSTEKTEKTH KGSKKQKKHR RARDRSRSSS
SSSQSSHSYK VEEYPEETEE REESTTGFDK SRLGTKDFVG PSERGGGRAR GTFQFRARGR
GWGRGNYSGN NNNSNNDFQK RNREEEWDPE YTPKSKKYYL HDDREGEGSD KWVSRGRGRG
AFPRGRGRFM FRKSSTSPKW AHDKFSGEEG EIEDDESGTE NREEKDNLQP TTE
//