ID H0VU28_CAVPO Unreviewed; 649 AA.
AC H0VU28;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN Name=CNNM2 {ECO:0000313|Ensembl:ENSCPOP00000014199.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014199.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014199.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014199.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484,
CC ECO:0000256|RuleBase:RU369091}.
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DR EMBL; AAKN02016514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VU28; -.
DR STRING; 10141.ENSCPOP00000014199; -.
DR Ensembl; ENSCPOT00000015901.3; ENSCPOP00000014199.3; ENSCPOG00000015746.4.
DR VEuPathDB; HostDB:ENSCPOG00000015746; -.
DR GeneTree; ENSGT00940000159034; -.
DR HOGENOM; CLU_011310_1_1_1; -.
DR InParanoid; H0VU28; -.
DR TreeFam; TF101012; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015746; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:Ensembl.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF22; METAL TRANSPORTER CNNM2; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 229..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369091"
FT DOMAIN 225..405
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT REGION 102..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 71914 MW; 0534B50375913660 CRC64;
VIGCGACEPG VKMAGGQAAA ALPTRKMAAR RGLITRGRGF LRVEAGRQLP VALLETPMWT
SGETQKKGNL GRRLGGLQLF KLRGDRCKNI KQRDVSRIAF TEQERGRQRA RRGRARPDGG
PQRCGIRTSD IIIQPHIVLN RRTSGIIEIE IKPLRKMEKS KSYYLCTSLS TPALGAGGAG
SAGVAGSAKS GAGVAGLQPP PWAETTWIYH DGEDTKMIVG EEKKFLLPFW LQVIFISLLL
CLSGMFSGLN LGLMALDPME LRIVQNCGTE KEKNYAKRIE PVRRQGNYLL CSLLLGNVLV
NTTLTILLDD IAGSGLVAVV VSTIGIVIFG EIVPQAICSR HGLAVGANTI FLTKFFMMMT
FPASYPVSKL LDCVLGQEIG TVYNREKLLE MLRVTDPYND LVKEELNIIQ GALELRTKTV
EDVMTPLRDC FMITGEAILD FNTMSEIMES GYTRIPVFEG ERSNIVDLLF VKDLAFVDPD
DCTPLKTITK FYNHPLHFVF NDTKLDAMLE EFKKGGEIRY LSLACSFSLH SPLYLNPHPS
DQPPRQVGQN FSSLIIAELK ALLNPVQSFP SSLNFHTDVS KIGKAVFVSF CFWLSGDLWR
QKIESCLWGW RMGEPSATKN SSLILDLTCL RLYENQSSLL IYSLEVNFL
//
