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Database: UniProt
Entry: H0VWW4_CAVPO
LinkDB: H0VWW4_CAVPO
Original site: H0VWW4_CAVPO 
ID   H0VWW4_CAVPO            Unreviewed;      2467 AA.
AC   H0VWW4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 66.
DE   SubName: Full=Nuclear receptor corepressor 2 {ECO:0000313|Ensembl:ENSCPOP00000015192.2};
GN   Name=NCOR2 {ECO:0000313|Ensembl:ENSCPOP00000015192.2};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015192.2, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000015192.2}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015192.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC       {ECO:0000256|ARBA:ARBA00010097}.
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DR   EMBL; AAKN02055653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000015192; -.
DR   Ensembl; ENSCPOT00000025739.2; ENSCPOP00000015192.2; ENSCPOG00000025915.2.
DR   VEuPathDB; HostDB:ENSCPOG00000025915; -.
DR   eggNOG; KOG1878; Eukaryota.
DR   GeneTree; ENSGT00940000159022; -.
DR   HOGENOM; CLU_000922_0_0_1; -.
DR   InParanoid; H0VWW4; -.
DR   OMA; RAMPHDS; -.
DR   TreeFam; TF106423; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000025915; Expressed in cerebellum and 13 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0017053; C:transcription repressor complex; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:1902894; P:negative regulation of miRNA transcription; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0010565; P:regulation of cellular ketone metabolic process; IEA:Ensembl.
DR   CDD; cd00167; SANT; 1.
DR   Gene3D; 1.20.5.430; -; 1.
DR   Gene3D; 1.20.58.1880; -; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR031557; N-CoR_GPS2_interact.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR   PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR   Pfam; PF15784; GPS2_interact; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 2.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   PROSITE; PS51294; HTH_MYB; 1.
DR   PROSITE; PS50090; MYB_LIKE; 1.
DR   PROSITE; PS51293; SANT; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          427..478
FT                   /note="SANT"
FT                   /evidence="ECO:0000259|PROSITE:PS51293"
FT   DOMAIN          600..651
FT                   /note="SANT"
FT                   /evidence="ECO:0000259|PROSITE:PS51293"
FT   DOMAIN          603..647
FT                   /note="Myb-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50090"
FT   DOMAIN          604..651
FT                   /note="HTH myb-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51294"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..1029
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1076..1113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1249..1275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1303..1323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1405..1441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1519..1574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1733..1825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1891..1980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1995..2019
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2033..2076
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2130..2185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2200..2220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2337..2453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..557
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..711
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        726..745
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..791
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        809..834
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        881..895
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        900..916
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1003..1017
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1090..1106
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1422..1440
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1736..1758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1759..1778
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1779..1825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1921..1948
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2206..2220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2378..2392
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2467 AA;  268114 MW;  FF2563B9B981DD13 CRC64;
     MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI TRPHTDVGLL EYQHHPRDYT SHLSPGSIIQ
     PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKADL EFMESKRPRL ELMSDPLLRP
     SPLLATGQPC ASEDLSKDRS LGGKLEPVSP PSPPHADAEL ELAPPRLSKE ELIQNMDRVD
     REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA
     AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
     RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG
     LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM
     KVYKDRQVMN MWSEQEKETF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK
     SLVRRSYRRR GKSQVRQQQQ PPPPPRSSQE EKEEKEKEAE KEEEKPDVEN GKEELIKEKT
     DDTSGEDNDE REAVASKGRK TANSQGRRKG RITRSMASEA NSDEAVTPQQ SAELASLEMN
     ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK NFYFNYKKRQ NLDDILQQHK
     LKMEKERNAR RKKKKAPATA SEEAAFPPVV EDEEMEASGA SGNEEEMAEE AEALPVPGSE
     VSRGECSGPA TVNNGSDTES VPSPRASEAT KEPKPPPTAV PDGLPAPPPT PPPDDAPTPV
     EPAPGPEASG RPTSPAAPSS PAVAPAVAPK EEEVEEAAMA VPPAEDREEQ KPQAPEQLAG
     DLGKVEEPGA APKELVQSVC VPEAAETALT RSLEDTPEGA PEGPLKTEKK EGAGGKASAA
     KSSGTPQDSD SSATCSADEV DEPEGSDKGR LLSPRPSLLT PGGDPRASAS PQKPLDLKQL
     KQRAAAIPPI VTKTHEPSQE DAALPQLAPA PPPPAQHLQP ESDAPHHPSS SPQGKRSPVP
     SAEKEAEKPT FFPAFAAEGQ KLPAEPPCWT SGLPFPMPPR EVIKASPHAP DASAFSYTPP
     GHPLPLSLHE GARPGPPRPP TISNPPPLIS SAKHPGVLER QMGTITQGVS VQLHGPFSEH
     AKAPVGPVTM GLPLAMDPKK LGTALGSVPG GSITRGIPST RAPPESPGTY RGSITHGTPA
     DVLYKGTITR IVGEESPSRL DRAREDSLPK GHVIYEGKKG HVLSYEGAMQ VSQCSKEDGR
     SSSGPAHEPA APKRTYDMME GRVGRALASA GIEGLMGRAI PPEHHSPHHL KEQHHLRGSI
     TQGTPRSYVE AQEDYLRREA KLLKREGSPP PPPPPRDLAE AYKGRPLDAL GPLKLKPAHE
     GLVATVKEAG RSIHEIPREE LRHTPELPLA PRPLKEGSIT QGTPLKYDTG TSSASSKKHD
     VRSIIGSPGR TFPPVLPLDV VADARVLERA CYEENLKGRP GAAGGSGGSI TRGAPVVVPE
     LGKPRQSPLT YEDHAAAFAS HLPRGSPVTT REPTPRLQEG DLLSSKTSQD RKLTSTPREV
     ARSPHSTVPE HPPHPMSPYE HLLRGVSGVD LYRSHIPLAF DPASISRGIP LDAAAAYYLP
     RHLAPNPTYP HLYPPYLIRG YPDTAALENR QTIINDYITS QQMHHSAATA MAQRADMLRG
     LSPRESSLAL NYATGPRGII DLSQVPHLPV LVPPTPSAPA AAMERLAYLP AAPQPFGSRH
     SSSPLSPGGP SHLTKPTAVS SSERERERDR ERDKSILTST TTVEHAPIWR PGTEQSSGSG
     SSGSRPTTHT HAHQHSPISP RTQDALQQRP SVLHNAGMKG LITSVEPSTP TVLRSTSTSS
     PIRLAATFPP TTHCPLGSTL DGVYPTLMEP VLLPKESTRG TRTERPRTDT GHAFLTKPPA
     REPTSSPSKS SEPRPLAPPS SSHAAITHTP AKSLAPHHAS PDPPAPPNSA SDPHRGKTQS
     KPFSIQELEL RSLGYHGYSP EGVEPVSPVS SPSLTQDKGL PKHLEELDKG HLEGELRHKP
     PGPGKIGGEA THLPHLRPVP ESQTASSPLL QTAPGVKGHQ RVVTLAQHIS EVITQDYTRH
     HPQQLSTTLP APLYSFPGAS CPVLDLRRPP SDLYLPHPEH NTPARGSPHS EGGKRSPEPS
     KTLVLGGEDG IEPVSPPESM SEPGHARSAM YPLLYRDGEQ AEPRMGSKSP GNTSQPPAFF
     SKLTESNSAM VKSKKQEINK KLNTHNRNEP EYNIGQPGTE IFNMPAITGA GLMTCRSQAV
     PEHTSTSMGL EAIIRKALMG KYDQWEEPPP LGANAFNPLN ASASLPTAAM PVTAAADGRS
     DPALTSPGGG GKAKVSGRPS SRKAKSPAPG LASGDRPPSV SSVHSEGDCN RRTPLTNRVW
     EDRPSSAGST PFPFNPLIMR LQAGVTASPP PPGLAAGSGP LAGAHHAWEE EPKPLLCSQY
     ETLSDSE
//
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