ID H0VWW4_CAVPO Unreviewed; 2467 AA.
AC H0VWW4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Nuclear receptor corepressor 2 {ECO:0000313|Ensembl:ENSCPOP00000015192.2};
GN Name=NCOR2 {ECO:0000313|Ensembl:ENSCPOP00000015192.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015192.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015192.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015192.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR EMBL; AAKN02055653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000015192; -.
DR Ensembl; ENSCPOT00000025739.2; ENSCPOP00000015192.2; ENSCPOG00000025915.2.
DR VEuPathDB; HostDB:ENSCPOG00000025915; -.
DR eggNOG; KOG1878; Eukaryota.
DR GeneTree; ENSGT00940000159022; -.
DR HOGENOM; CLU_000922_0_0_1; -.
DR InParanoid; H0VWW4; -.
DR OMA; RAMPHDS; -.
DR TreeFam; TF106423; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000025915; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0017053; C:transcription repressor complex; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1902894; P:negative regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0010565; P:regulation of cellular ketone metabolic process; IEA:Ensembl.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 427..478
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 600..651
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 603..647
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 604..651
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1995..2019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2033..2076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2130..2185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2200..2220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2337..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..711
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..791
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1422..1440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1759..1778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1779..1825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1921..1948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2206..2220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2378..2392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2467 AA; 268114 MW; FF2563B9B981DD13 CRC64;
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI TRPHTDVGLL EYQHHPRDYT SHLSPGSIIQ
PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKADL EFMESKRPRL ELMSDPLLRP
SPLLATGQPC ASEDLSKDRS LGGKLEPVSP PSPPHADAEL ELAPPRLSKE ELIQNMDRVD
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG
LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM
KVYKDRQVMN MWSEQEKETF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK
SLVRRSYRRR GKSQVRQQQQ PPPPPRSSQE EKEEKEKEAE KEEEKPDVEN GKEELIKEKT
DDTSGEDNDE REAVASKGRK TANSQGRRKG RITRSMASEA NSDEAVTPQQ SAELASLEMN
ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK NFYFNYKKRQ NLDDILQQHK
LKMEKERNAR RKKKKAPATA SEEAAFPPVV EDEEMEASGA SGNEEEMAEE AEALPVPGSE
VSRGECSGPA TVNNGSDTES VPSPRASEAT KEPKPPPTAV PDGLPAPPPT PPPDDAPTPV
EPAPGPEASG RPTSPAAPSS PAVAPAVAPK EEEVEEAAMA VPPAEDREEQ KPQAPEQLAG
DLGKVEEPGA APKELVQSVC VPEAAETALT RSLEDTPEGA PEGPLKTEKK EGAGGKASAA
KSSGTPQDSD SSATCSADEV DEPEGSDKGR LLSPRPSLLT PGGDPRASAS PQKPLDLKQL
KQRAAAIPPI VTKTHEPSQE DAALPQLAPA PPPPAQHLQP ESDAPHHPSS SPQGKRSPVP
SAEKEAEKPT FFPAFAAEGQ KLPAEPPCWT SGLPFPMPPR EVIKASPHAP DASAFSYTPP
GHPLPLSLHE GARPGPPRPP TISNPPPLIS SAKHPGVLER QMGTITQGVS VQLHGPFSEH
AKAPVGPVTM GLPLAMDPKK LGTALGSVPG GSITRGIPST RAPPESPGTY RGSITHGTPA
DVLYKGTITR IVGEESPSRL DRAREDSLPK GHVIYEGKKG HVLSYEGAMQ VSQCSKEDGR
SSSGPAHEPA APKRTYDMME GRVGRALASA GIEGLMGRAI PPEHHSPHHL KEQHHLRGSI
TQGTPRSYVE AQEDYLRREA KLLKREGSPP PPPPPRDLAE AYKGRPLDAL GPLKLKPAHE
GLVATVKEAG RSIHEIPREE LRHTPELPLA PRPLKEGSIT QGTPLKYDTG TSSASSKKHD
VRSIIGSPGR TFPPVLPLDV VADARVLERA CYEENLKGRP GAAGGSGGSI TRGAPVVVPE
LGKPRQSPLT YEDHAAAFAS HLPRGSPVTT REPTPRLQEG DLLSSKTSQD RKLTSTPREV
ARSPHSTVPE HPPHPMSPYE HLLRGVSGVD LYRSHIPLAF DPASISRGIP LDAAAAYYLP
RHLAPNPTYP HLYPPYLIRG YPDTAALENR QTIINDYITS QQMHHSAATA MAQRADMLRG
LSPRESSLAL NYATGPRGII DLSQVPHLPV LVPPTPSAPA AAMERLAYLP AAPQPFGSRH
SSSPLSPGGP SHLTKPTAVS SSERERERDR ERDKSILTST TTVEHAPIWR PGTEQSSGSG
SSGSRPTTHT HAHQHSPISP RTQDALQQRP SVLHNAGMKG LITSVEPSTP TVLRSTSTSS
PIRLAATFPP TTHCPLGSTL DGVYPTLMEP VLLPKESTRG TRTERPRTDT GHAFLTKPPA
REPTSSPSKS SEPRPLAPPS SSHAAITHTP AKSLAPHHAS PDPPAPPNSA SDPHRGKTQS
KPFSIQELEL RSLGYHGYSP EGVEPVSPVS SPSLTQDKGL PKHLEELDKG HLEGELRHKP
PGPGKIGGEA THLPHLRPVP ESQTASSPLL QTAPGVKGHQ RVVTLAQHIS EVITQDYTRH
HPQQLSTTLP APLYSFPGAS CPVLDLRRPP SDLYLPHPEH NTPARGSPHS EGGKRSPEPS
KTLVLGGEDG IEPVSPPESM SEPGHARSAM YPLLYRDGEQ AEPRMGSKSP GNTSQPPAFF
SKLTESNSAM VKSKKQEINK KLNTHNRNEP EYNIGQPGTE IFNMPAITGA GLMTCRSQAV
PEHTSTSMGL EAIIRKALMG KYDQWEEPPP LGANAFNPLN ASASLPTAAM PVTAAADGRS
DPALTSPGGG GKAKVSGRPS SRKAKSPAPG LASGDRPPSV SSVHSEGDCN RRTPLTNRVW
EDRPSSAGST PFPFNPLIMR LQAGVTASPP PPGLAAGSGP LAGAHHAWEE EPKPLLCSQY
ETLSDSE
//