ID H0VXA3_CAVPO Unreviewed; 839 AA.
AC H0VXA3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Adhesion G protein-coupled receptor D2 {ECO:0000313|Ensembl:ENSCPOP00000015333.2};
GN Name=ADGRD2 {ECO:0000313|Ensembl:ENSCPOP00000015333.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015333.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015333.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015333.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAKN02030285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02030286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VXA3; -.
DR STRING; 10141.ENSCPOP00000015333; -.
DR Ensembl; ENSCPOT00000023450.2; ENSCPOP00000015333.2; ENSCPOG00000027184.2.
DR VEuPathDB; HostDB:ENSCPOG00000027184; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161534; -.
DR HOGENOM; CLU_015074_0_0_1; -.
DR InParanoid; H0VXA3; -.
DR OMA; SCEQQFG; -.
DR TreeFam; TF351999; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000027184; Expressed in adrenal gland and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF58; ADHESION G-PROTEIN COUPLED RECEPTOR D2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..758
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 97..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 90274 MW; 27ECDCEA9B9C40D3 CRC64;
RSGASLAPPL TPQQSQGFLG PQVDLVAPGE VVETTDSVCK FPGQRLSWWQ AQESCEQRFG
HLALGPPDGI LAPPLSDSVW VGQRDASMQR LPQRREWGSG MGAYSDSPLG KAPKRNTSPY
LPALLRRMES RSDPVHLYAM LPDQLPMPSL GSVTTGRSVR APPTPRGGSS GCCLDPALAP
LVPSEECPTW NPGLGTAGSE LCVQARLFLC CYRKEIYEQL RDIQLWPGQD VISRVNALAE
DTVLLPDPLS EAPAPLSLDK ACSFLGILES VLAPEPELGP AALLAVVHFL KRVSALGARE
PQPLAGPWEQ LARGVLSVTS LVLEERLAGT WLSISKVVGG PMALLATVQP LASLLSTTLS
PEQPRIHIQY RHMGLSGVTA IHSWFSSSVF QRTLGAPSLK PQFPASPEEA SRMQRFLSTQ
VGSAVLSSEL QDAAGPVSTA VTFHLRHQAQ ELSASSPPPS PETGGSWATT SCSVLALHRD
STACFCNHST SFAILLQVYD VQRGPEEESL LRTLSFVGCG VSFCALATTF LLFLVARVPK
SERTTVHKNL TFSLASAEGL LMASEWAKTS QVACVAVTAA MHLLFLAAFS WMLVEGLLLW
SKVVAVSMRP GPRMWLYYTA GWGSPTVIVA VTLVTSPGDY VASGHCWLNV HTDAIWAFAG
PVLFVLAANT CILFRVVTVT VSSARRRARM LSPQPGLQQQ LGIQMWATVK PVLVLLPVLG
LTWLVGVLVH LSPAWAYAAV GLNSLQGPYI FLVYAACNAE VRNALQRVTE KKAALAAPRG
GPDAHARAFQ TRSQEGPTAW SPPRRHLALR GPASPPAVPR FPLGRRQRRE DSDTPCQLV
//
