ID H0VY70_CAVPO Unreviewed; 496 AA.
AC H0VY70;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Tubulin tyrosine ligase like 10 {ECO:0000313|Ensembl:ENSCPOP00000015651.2};
GN Name=TTLL10 {ECO:0000313|Ensembl:ENSCPOP00000015651.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015651.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015651.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015651.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02055863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VY70; -.
DR STRING; 10141.ENSCPOP00000015651; -.
DR Ensembl; ENSCPOT00000021455.2; ENSCPOP00000015651.2; ENSCPOG00000026364.2.
DR VEuPathDB; HostDB:ENSCPOG00000026364; -.
DR eggNOG; KOG2157; Eukaryota.
DR GeneTree; ENSGT00940000160919; -.
DR HOGENOM; CLU_022993_1_0_1; -.
DR InParanoid; H0VY70; -.
DR OMA; SRMWICK; -.
DR TreeFam; TF329363; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000026364; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:UniProt.
DR GO; GO:0140096; F:catalytic activity, acting on a protein; IEA:UniProt.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR InterPro; IPR027752; TTLL10.
DR PANTHER; PTHR46810; INACTIVE POLYGLYCYLASE TTLL10; 1.
DR PANTHER; PTHR46810:SF1; INACTIVE POLYGLYCYLASE TTLL10; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 441..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..480
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 56359 MW; 3BB90A2274B554FA CRC64;
MGSSGEEQLS QLVSDADLLD GADTASCPAA LLKEFLQDRD KHFPSNGQGP FFYIGGSNGA
SIISAYCRSK GWQRTQDSRR EDYKLKWCEI KCRDNYHSFR EGQQLLFQLP NNKLLTTKIG
LLSALREHER TVSKVNRMPP GTQPRVLKME DFFPETYRLD VSNERQAFFT LFDETQMWIC
KPTASNQGKG IFLIRSQEEL ATLQAKIQSM DDGPLHCKIP FRGPQARVVQ RYIQNPLLLN
GKKFDVRSYL LIACAVPYMV FFGHGYARLT LNLYDPHSSD LSGHLTNQFM QKQSPLYMLL
KEDTVWSMDH LNRYINDKFQ RTKGLPQDWV FTTFTKRMQQ IMSHCFLAVK SKLECKLGYF
DLIGCDFLID ENFKVWLLEM NSNPALHTNC EVLKKVIPGV VMETLDLALE TSQKSLRGQK
MLPLRAQRRF ALLHNGEADP RPLLRPRLGA TGARPRPLAP LPHACPRPRP PGPAPNTGPA
PGEPCAERRG TGHRGS
//
