ID H0VYJ9_CAVPO Unreviewed; 1418 AA.
AC H0VYJ9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=A-kinase anchoring protein 13 {ECO:0008006|Google:ProtNLM};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015781.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015781.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015781.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AAKN02016080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02016082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000015781; -.
DR Ensembl; ENSCPOT00000009039.3; ENSCPOP00000015781.2; ENSCPOG00000013090.4.
DR VEuPathDB; HostDB:ENSCPOG00000013090; -.
DR GeneTree; ENSGT00940000154146; -.
DR HOGENOM; CLU_002466_1_0_1; -.
DR InParanoid; H0VYJ9; -.
DR OMA; SIMTFHG; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013090; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20878; C1_AKAP13; 1.
DR CDD; cd13392; PH_AKAP13; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944:SF18; A-KINASE ANCHOR PROTEIN 13; 1.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 399..446
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 600..797
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 837..939
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 65..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 953..984
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 65..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 160486 MW; 362F8B8DF9D0C331 CRC64;
MYERHKRRYS LCDISKVDRT VDVVLLKINR ESWCALEPCA AATSLLASKQ NPKCENLDVG
PDRECTSKQG VHQRESGSDS DLFRSLSDDT DSIVFPKPEI CDIVGSSSTD DTASLDRHSS
QGSDVSLPQI SKLNRARDQQ SSDGFCSHGM EAEGQENESE PAASGEIEEE EMDSITEVPA
NCRRSSMRSL SPFRRHSWGP GKNAASDAEM NHRSFSLEGL IGAAGIGNKL SSSLEVNAVN
SKELRHTFSG EERGDSLMSL SEEDLESHQR EHRMFDQQMY HRAKQQGFNY CTSAISSPLT
KSISLMTISH PGLDIIFLKT SFLCFFSITE ENYDFLPPNP SKKDFEEKSG TKVSRTFSYI
RNKMSSSKKS KEKEKEKEKI KEKEKDSKEK EKDKKTVNGH TFSSIPIVGP ISCTHCLKPF
TNKDAYTCAN CSAFVHKGCR ESLASCAKVK MKPKGNFQAQ DTSSLPVIMR NKPSQPKERP
RSAVLLAEDT IAAPVFANRR SQQSVSLSKS VSIQNITGVG SEENMSNTWK FLSHSTDSLN
KISKVNESTE SLTDEGVGTD MNEGQLMGDF EIDSKQLEAE SWSRVVDSKF LKQQKKDVVK
QQEVIYELMQ TEFHHIRTLK IMSDVYSRGM MTELLFEQQT VDRLFPCLDE LISIHSQFFQ
RILERKKESL VDKSEKNFLV KRIGDVLVNQ FSGDSAERLK KTYGKFCGQH NQSVNYFKDL
YTKDKRFQAF VKKKMSSSVV RRLGIPECIL LVTQRITKYP VLFQRILQCT KDSEVERDDL
AQSLSLVKDV IGAVDSKVAS YEKKVRLNEI YMKTDSKSIM RMKSGQMFAK EDLKRKKLVR
DGSVFLKSAT GRLKEVQAVL LTDILVFLQE KDQKYIFASL DQKSTVISLK KLIVREVAHE
EKGLFLISMG VKDPEMVEVH ASSKEERNSW IQIIQDTINT LNRDEDEGIP SENEEEKKML
DTKTRELKEQ LQQKDQQILL LLEEKEMIFR DMTQCSTPLP DDCSPAQSPR TLFRSNTEEA
LKGGPLMKSA INEVELLQGL VSGSLGGTFA QAVGSSVEQE AMVGPVSLPR RAETFGGFDS
HQMNVAKGGE KEEGDEGQDL RRTESDSGLK KGGNANLVFV PKRNSEVVRS IVHLYELLST
LQGVVLQQDS YIEDQKLVLT ERALTRSVSR PSSLIEQEKQ RSLEKQRQDL ANLQKQQAQH
LEEKRRRERE WEARERELRE REARLAEREE KVQRGQQDLH RDWEELQQKK GVYQSDLERL
RTAQKQLERE QEQLRRDMEQ FSQRQMERNL SQVSQHTKLM RIPSFLPSPE ESSLPSVPAV
TKSGSLDSEL SVSPKRNSIS RTHKDKGPFH ILSSTSQTNK VPEGQSQAPS STSTSTRLFG
LAKPKEKKEK KKKNKGSRPQ PGDGPASEAS AEGEEIFC
//
