ID H0VYQ1_CAVPO Unreviewed; 896 AA.
AC H0VYQ1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Nuclear transcription factor, X-box binding like 1 {ECO:0000313|Ensembl:ENSCPOP00000015833.2};
GN Name=NFXL1 {ECO:0000313|Ensembl:ENSCPOP00000015833.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000015833.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000015833.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000015833.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR EMBL; AAKN02028220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02028221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02028222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013009916.1; XM_013154462.1.
DR RefSeq; XP_013009917.1; XM_013154463.1.
DR RefSeq; XP_013009918.1; XM_013154464.1.
DR RefSeq; XP_013009919.1; XM_013154465.1.
DR RefSeq; XP_013009920.1; XM_013154466.1.
DR Ensembl; ENSCPOT00000019738.2; ENSCPOP00000015833.2; ENSCPOG00000014371.4.
DR Ensembl; ENSCPOT00000032904.1; ENSCPOP00000026634.1; ENSCPOG00000014371.4.
DR GeneID; 100720623; -.
DR KEGG; cpoc:100720623; -.
DR CTD; 152518; -.
DR VEuPathDB; HostDB:ENSCPOG00000014371; -.
DR GeneTree; ENSGT00940000157059; -.
DR HOGENOM; CLU_014224_0_0_1; -.
DR OrthoDB; 1412at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014371; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06008; NF-X1-zinc-finger; 6.
DR CDD; cd16697; RING-CH-C4HC3_NFXL1; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360:SF1; NF-X1-TYPE ZINC FINGER PROTEIN NFXL1; 1.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR Pfam; PF01422; zf-NF-X1; 11.
DR SMART; SM00438; ZnF_NFX; 11.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 874..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..205
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 815..855
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 896 AA; 100509 MW; 646E5940663F88EF CRC64;
MDASWRQVAG GRGRARGRPA AAPSPGNGVP LRSAGGGREK RSGGPVPAGP GRGRGPETPA
AAELMSQRKF EEIKKANQAA AKKLVEEHFS SSSEEEGDED FEGKQGKIVT KTFITYTTQT
DGDTRELERT KQYVNEAFQA GAVTCLICIA SVKRSQAVWS CLGCFSIFHM PCIQKWAKDS
QFLLSSLTDD DFGTRDYPWP CPKCRFEYKR SETPSRYYCY CGKVEDPPLD PWLVPHSCGQ
VCERQFKPPC GHKCLLLCHP GPCPPCPKMV TTTCYCKKAK SIPRRCSAKE WSCQQPCGQK
LLCGQHKCEN PCHAGNCQPC PRVSRQKCVC GKKVAERSCA SPLWHCDQVC GKTLPCRNHT
CEQVCHIGAC GECPRSGKRF CPCQKSKFSL PCTEDVPTCG DSCDKVLECG IHRCSQRCHR
GPCETCRQEV EKQCRCGKHT KRMPCHKPYL CETKCVKMRD CQKHQCRRKC CPGNCPPCDQ
NCGRTLGCRN HKCPSVCHRG SCYPCPETVD VKCNCGNAKL TVPCGRERTT KPPKCKELCS
RPPTCHHTSR EKHRCHFGPC PPCHQPCKKV LEKCGHLCPA SCHDQALVKQ TGRHQPTGPW
EQSSEPAFIE TALPCPPCQV PIPLECLGKH EVSPLPCHAE GPYSCKRVCG RILDCQNHTC
LRECHKVTEV DGYTSKNKAG PECLRCEEGC SKSRPLGCPH PCVLPCHPGE CPPCVQMLRI
KCHCKITSLY VECRKITTAD VNEKNRLSCC KNQCPKELPC GHRCKEMCHP GECPFNCNQK
VKLRCPCKRI KKELQCSKVR ENQVSIECDT TCKEMKRKAS EIKEAEAKAA LEEEKRRQQA
ELEAFENRLR GRRKKNRKRD EVAIELSFWQ KYKYYFLPVC GVAMVVFAWY ITYDTD
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