ID H0W1R8_CAVPO Unreviewed; 272 AA.
AC H0W1R8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN Name=IL1A {ECO:0000313|Ensembl:ENSCPOP00000016908.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000016908.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000016908.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016908.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU003753}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003753}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC ECO:0000256|RuleBase:RU003753}.
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DR EMBL; AAKN02046997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003465104.1; XM_003465056.2.
DR AlphaFoldDB; H0W1R8; -.
DR Ensembl; ENSCPOT00000025309.2; ENSCPOP00000016908.2; ENSCPOG00000026158.2.
DR GeneID; 100135555; -.
DR KEGG; cpoc:100135555; -.
DR CTD; 3552; -.
DR VEuPathDB; HostDB:ENSCPOG00000026158; -.
DR GeneTree; ENSGT00390000013353; -.
DR InParanoid; H0W1R8; -.
DR OMA; SNMKYNF; -.
DR OrthoDB; 4640109at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000026158; Expressed in zone of skin and 3 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001660; P:fever generation; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR003295; IL-1_alpha.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR003502; IL-1_propep.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078:SF33; INTERLEUKIN-1 ALPHA; 1.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR Pfam; PF00340; IL1; 1.
DR Pfam; PF02394; IL1_propep; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01358; INTRLEUKIN1A.
DR PRINTS; PR01357; INTRLEUKN1AB.
DR SMART; SM00125; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU003753};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|RuleBase:RU003753};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|RuleBase:RU003753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Pyrogen {ECO:0000256|ARBA:ARBA00022620, ECO:0000256|RuleBase:RU003753};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Secreted {ECO:0000256|RuleBase:RU003753}.
FT DOMAIN 1..114
FT /note="Interleukin-1 propeptide"
FT /evidence="ECO:0000259|Pfam:PF02394"
FT REGION 41..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 31027 MW; AE695E36424D1A85 CRC64;
MAQCPNMLED LKSCYSENEE YASAIDHLSL NQKSFYDTNY DPLHENRVDK PVSPNPYENS
EESNFTLEDS SDSSAVVLTS AHGEVLKKRR LSLNQTMSNE DLEAIANDSE EEIIEPWSVP
YSFQSNLKFK YQRSIKKGAV ITDAMHQSLI RESNGQHLKA MHVVDRKHEV KFDIDGYVST
ATRIRPVTLK ISKTQLYVCA QEEGQPVLLK EMPETPRVIT GNDVNLVFFW EIQRNHNFFR
SAANTDLFIA TKMTGPVHMA KTLPSMLDFQ IS
//
