ID H0W264_CAVPO Unreviewed; 483 AA.
AC H0W264;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=PR/SET domain 11 {ECO:0000313|Ensembl:ENSCPOP00000017055.2};
GN Name=PRDM11 {ECO:0000313|Ensembl:ENSCPOP00000017055.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017055.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017055.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017055.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02046827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02046828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0W264; -.
DR Ensembl; ENSCPOT00000020907.2; ENSCPOP00000017055.2; ENSCPOG00000019447.2.
DR VEuPathDB; HostDB:ENSCPOG00000019447; -.
DR GeneTree; ENSGT00940000159837; -.
DR HOGENOM; CLU_593911_0_0_1; -.
DR TreeFam; TF316279; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000019447; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR CDD; cd19195; PR-SET_PRDM11; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044405; PRDM11_PR/SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46880:SF11; PR_SET DOMAIN 11; 1.
DR PANTHER; PTHR46880; RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 92..226
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 244..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 54575 MW; 81B638BE7C8E2212 CRC64;
MTENMKECLA QTKAAVGDMV TVVKTEVCSP LRDQEYGQPC SRRPEPLAME VEPKKLKGKR
DLMVPKSFQQ VDFWFCESCQ EYFVDECPNH GPPVFVSDTP VPVGIPDRAA LTIPQGMEVI
KEAGGESDVR CINEVIPKGH IFGPYEGQIS TQDKSAGFFS WLIVDKNNRY KSIDGSDETK
ANWMRYVVIS REEREQNLLA FQHSERIYFR ACRDIRPGER LRVWYSEDYM KRLHSMSQET
IHRNLARGEK RLPREKSEQA LDNPEDLRGP IHLPVLRQGK SPYKRGFDEG DVHPQTKKKK
IDLIFKDVLE ASLESAKVEA HQLALSTSLV IRKVPKYQDD TYGRCATVSR TQGEGDWKTP
QGLAKEPGPL EDEDEEPAPF KADSPAEASL ASDPHELPTT SFCPNCIRLK KKVRELQAEL
DMLKSGKLPE PPVLPPQVLE LPEFSDPAGK LVWMRPVGAS VPQKFRCRRG VCCVLDPLPF
SGG
//
