ID H0W3X7_CAVPO Unreviewed; 418 AA.
AC H0W3X7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Tektin {ECO:0000256|RuleBase:RU367040};
GN Name=TEKT1 {ECO:0000313|Ensembl:ENSCPOP00000017676.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017676.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017676.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017676.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. Required for normal sperm mobility.
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|RuleBase:RU367040}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}.
CC -!- SIMILARITY: Belongs to the tektin family.
CC {ECO:0000256|ARBA:ARBA00007209, ECO:0000256|RuleBase:RU367040}.
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DR EMBL; AAKN02033215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003469690.1; XM_003469642.3.
DR RefSeq; XP_013007824.1; XM_013152370.1.
DR RefSeq; XP_013007825.1; XM_013152371.1.
DR RefSeq; XP_013007826.1; XM_013152372.1.
DR RefSeq; XP_013007827.1; XM_013152373.1.
DR RefSeq; XP_013007828.1; XM_013152374.1.
DR RefSeq; XP_013007829.1; XM_013152375.1.
DR RefSeq; XP_013007830.1; XM_013152376.1.
DR RefSeq; XP_013007831.1; XM_013152377.1.
DR AlphaFoldDB; H0W3X7; -.
DR STRING; 10141.ENSCPOP00000017676; -.
DR Ensembl; ENSCPOT00000024230.2; ENSCPOP00000017676.1; ENSCPOG00000025887.2.
DR GeneID; 100725470; -.
DR KEGG; cpoc:100725470; -.
DR CTD; 83659; -.
DR VEuPathDB; HostDB:ENSCPOG00000025887; -.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_2_1; -.
DR InParanoid; H0W3X7; -.
DR OMA; VELCYDT; -.
DR OrthoDB; 2875854at2759; -.
DR TreeFam; TF320754; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000025887; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0005879; C:axonemal microtubule; IEA:Ensembl.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:UniProtKB-UniRule.
DR InterPro; IPR048256; Tektin-like.
DR InterPro; IPR000435; Tektins.
DR PANTHER; PTHR19960; TEKTIN; 1.
DR PANTHER; PTHR19960:SF25; TEKTIN-1; 1.
DR Pfam; PF03148; Tektin; 1.
DR PRINTS; PR00511; TEKTIN.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367040};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367040};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846, ECO:0000256|RuleBase:RU367040};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT COILED 268..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 341..382
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 418 AA; 48388 MW; 781D9CBAD8251219 CRC64;
MAKLLQALPK FLPLDWYIAN KNQYHRAEAQ KSRSERLVAE SQRLVDEVDK RTRKSQSDVN
KKLEQRLEEV RFWKKELDDK LEQLVHETED LLSYKSRLEK ALETFNEPLH ITERCLAYRE
KRVGIDLVHD VVEQELLKEA EIIRGIVALL TRTLEETSEQ IRLNRSAKYS LEKDLRDKFT
AITIDDVCFS LNNNSPNIRY SENVVRIEPN SVSLEDWLDF SNMNVQKADK QRNNSLTLKA
LVDQILSQTA SDLRRQCDIV DTAFQNGLRE TKDAKEKLAA HLAKVMEEIA SQEKNIAILE
KAILDQEGPA KLAHTRLETR AQRPNVELCR DVAQYRLIKE VHEINHNVAR LKETLAQAQV
ELKGLNRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPPR AVEDHGEALG GLRPEAVC
//
