ID H0W499_CAVPO Unreviewed; 523 AA.
AC H0W499;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Zic family member 2 {ECO:0000313|Ensembl:ENSCPOP00000017799.1};
GN Name=ZIC2 {ECO:0000313|Ensembl:ENSCPOP00000017799.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017799.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017799.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017799.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00010831}.
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DR EMBL; AAKN02008610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003477648.1; XM_003477600.3.
DR AlphaFoldDB; H0W499; -.
DR STRING; 10141.ENSCPOP00000017799; -.
DR Ensembl; ENSCPOT00000024531.2; ENSCPOP00000017799.1; ENSCPOG00000026926.2.
DR GeneID; 100723859; -.
DR KEGG; cpoc:100723859; -.
DR CTD; 7546; -.
DR VEuPathDB; HostDB:ENSCPOG00000026926; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160645; -.
DR InParanoid; H0W499; -.
DR OMA; HGPHSSQ; -.
DR OrthoDB; 2900023at2759; -.
DR TreeFam; TF351425; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000026926; Expressed in cerebellum and 2 other cell types or tissues.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR041643; Znf_ZIC.
DR PANTHER; PTHR19818:SF27; ZINC FINGER PROTEIN ZIC 2; 1.
DR PANTHER; PTHR19818; ZINC FINGER PROTEIN ZIC AND GLI; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF18366; zf_ZIC; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 304..331
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 332..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 362..391
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 392..414
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 408..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 54434 MW; F4EC919828DDEF22 CRC64;
MLLDAGPQFP AIGVGSFARH HHHSAAAAAA AAAEMQDREL SLAAAQNGFV DSAAAHMGAF
KLNPGAHELS PGQSSAFTSQ GPGAYPGSAA AAAAAAALGP HAAHVGSYSG PPFNSTRDFL
FRSRGFGDSA PGGGQHGLFG PGAGSLHHAH SDAQGHLLFP GLPEQHGPHG SQNVLNGQMR
LGLPGEVFGR SEQYRQVASP RTDPYSAAQL HNQYGPMNMN MGMNMAAAAA HHHHHHHHPG
AFFRYMRQQC IKQELICKWI DPEQLSNPKK SCNKTFSTMH ELVTHVSVEH VGGPEQSNHV
CFWEECPREG KPFKAKYKLV NHIRVHTGEK PFPCPFPGCG KVFARSENLK IHKRTHTGEK
PFQCEFEGCD RRFANSSDRK KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESFPQG
SESSPAASSG YESSTSPGLV SPSAEPQSSS NLSPAAAAAA AAAAAAVSAV HRGGGSGGGS
GGGSGSGGGG GGAGGGGGGS SGAGSGTAGA HSGLSSNFNE WYV
//
