ID H0W5S2_CAVPO Unreviewed; 1157 AA.
AC H0W5S2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Zinc finger protein 516 {ECO:0000313|Ensembl:ENSCPOP00000018326.1};
GN Name=ZNF516 {ECO:0000313|Ensembl:ENSCPOP00000018326.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000018326.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000018326.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000018326.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AAKN02051422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003463374.1; XM_003463326.3.
DR AlphaFoldDB; H0W5S2; -.
DR STRING; 10141.ENSCPOP00000018326; -.
DR Ensembl; ENSCPOT00000026827.2; ENSCPOP00000018326.1; ENSCPOG00000020183.2.
DR VEuPathDB; HostDB:ENSCPOG00000020183; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160839; -.
DR HOGENOM; CLU_009481_0_0_1; -.
DR InParanoid; H0W5S2; -.
DR OMA; YQGWGVG; -.
DR OrthoDB; 3849084at2759; -.
DR TreeFam; TF332241; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000020183; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060612; P:adipose tissue development; IEA:Ensembl.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF3; ZINC FINGER PROTEIN 516; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 34..61
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 62..84
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 236..263
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 264..291
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 323..350
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 504..531
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1092..1115
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..997
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 125052 MW; 635AEFD14BF78120 CRC64;
MDRSREAEME LKRGPSPPRA SRSQEVDGDK AACHSCCICG KSFPFQSSLS QHMRKHTGEK
PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPETGEV QLGEMRVSEG LDGCASPTKS
TSACNRILNG VAQVDSSKIL LRSSRKEVEG PAGAVEEAEA VTQCSFCKSQ FQRKKDLELH
VHQAHKPFRC RLCSYMTLRE ESLLSHIERD HITAQVPNGG EACMENGKPD LSPGEFPCEV
CGQAFSQTWF LKAHMKKHRG SFDHGCHICG RRFKEPWFLK NHMKAHGPKT GSKNRPKSDL
DPIATINNVV QEEVIVAGLS LYEVCTKCGN LFTNLDSLNA HNAIHRKVEA SRTRALAEEP
ATESPLDTKQ FFLQCLNLRP SVADDASSAG QAGRRVAELD PINSYQAWQL ATRGKVAEPA
EYLKYGAWDE ALAGDVAFDK DRREYILVSQ EKRKREQDAP TVQGPPRKRA SLPGDPVLPG
HFEPRPVARA SRRAAASAGH GKSSECFECG KIFRTYHQMV LHSRVHRRAR RDRDSNGDRV
ARARCGSLSE GDSASQPSSP GSACATVDSP GSGLADEAAD DSGEESMPEP APGGHPRRCC
SSEDIASTVL SNGDQSHRLG NNLPGKDVSE SKVGIATPVS ILENSSRETS KRPEQHRFSL
DLKMPAFRPK QEAPSSSDDV DFPSSPEGAD LQLTLESQAG HPKDKLSDLH SKEHSGGGKS
TPAPDLTPLD LSARSTRDDS SSKEVASSLQ AALVIHPCPY CNHKTYYPEV LWMHKRVWHR
VSCNSMAPQW IQPNGYKSIR SNLVYLARNG RTGPPPALGG KECQPLLVAR FTRTQVPGGA
PGPKGSSSPL GVTTKAATMP KNKESHSTGP CALWATGPDG YRQTKPSQGQ ESSSTSVQGP
PAKSKLEASS KPAPALGSGG LGRSATPTPS VITRVGAQPL ASNKPVENFG VSSVGAGFAP
PNKHSAPDSL KAKFSPQPQG QPPAKGEVSP PLPLREPPSK AAQELRMLAT CSAGSRGDAA
LQGQPGMAGA PVLHSIKQEP VAEAHEKRLD ILNIFKTYIP KDFATLYQGW GVSSPGPEHR
GTLRTQARPG DFVCVECGKN FHQPSNLRAH MRAHTVVFEC DGPRGAEVHT VSMDAPKQGR
DHANTGTVQT VPLRKGT
//