ID H0W685_CAVPO Unreviewed; 459 AA.
AC H0W685;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Mitochondrial ribosome associated GTPase 2 {ECO:0000313|Ensembl:ENSCPOP00000018489.2};
GN Name=MTG2 {ECO:0000313|Ensembl:ENSCPOP00000018489.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000018489.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000018489.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000018489.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. OBG GTPase family. {ECO:0000256|ARBA:ARBA00007699}.
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DR EMBL; AAKN02052586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0W685; -.
DR STRING; 10141.ENSCPOP00000018489; -.
DR Ensembl; ENSCPOT00000021572.2; ENSCPOP00000018489.2; ENSCPOG00000023202.2.
DR VEuPathDB; HostDB:ENSCPOG00000023202; -.
DR eggNOG; KOG1489; Eukaryota.
DR GeneTree; ENSGT00940000157379; -.
DR HOGENOM; CLU_011747_2_3_1; -.
DR InParanoid; H0W685; -.
DR OMA; VVFDWEP; -.
DR TreeFam; TF314774; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000023202; Expressed in adrenal gland and 13 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005761; C:mitochondrial ribosome; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0070129; P:regulation of mitochondrial translation; IEA:Ensembl.
DR GO; GO:0044065; P:regulation of respiratory system process; IEA:Ensembl.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01898; Obg; 1.
DR Gene3D; 2.70.210.12; GTP1/OBG domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01454; GTPase_Obg; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR InterPro; IPR006169; GTP1_OBG_dom.
DR InterPro; IPR036726; GTP1_OBG_dom_sf.
DR InterPro; IPR045086; OBG_GTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR02729; Obg_CgtA; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR11702; DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11702:SF31; MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2; 1.
DR Pfam; PF01018; GTP1_OBG; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF82051; Obg GTP-binding protein N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51710; G_OBG; 1.
DR PROSITE; PS51883; OBG; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 123..277
FT /note="Obg"
FT /evidence="ECO:0000259|PROSITE:PS51883"
FT DOMAIN 278..443
FT /note="OBG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51710"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 49288 MW; DD0B1EF41C790DBE CRC64;
MGARGSMSLS GGGQRESPDV LAWNTPRRLS SASFGRSGLA QVPYCPVPLS LGDMIPGRLS
SARPWTMLEG IMRGAVRTPA GLRLSRLLPQ QGHPRPLSMG CVDCTKHREP PGKKPLSEKK
LKKHFVDCRR VLVRGGGGGS GMSCFHSEPR KEFGGPDGGD GGSGGHVILR VDRQVKSLSS
VRSQYQGFSG EDGGSKNCSG RGGAALYIRV PVGTLVKEGD KVIADLSCPG DEYIAAHGGA
GGKGNRFFLA NDNRAPVTCT PGEPGQERVL HLELKTVAHA GMVGFPNAGK SSLLRVISNA
KPAVASYPFT TLKPHVGIVH YADHQQLAVA DIPGIIQGAH QNRGLGLSFL RHLERCRFLL
FVVDLALPEP WTQLEHLKYE LEKYKEGLSS RPHVVIGNKI DLPQARAHLA PLQAHLGQEV
IALSALTGEN LEQLLLHLKV LYDAYVEAEL GQGCQPLRW
//
