ID H0W7Q1_CAVPO Unreviewed; 964 AA.
AC H0W7Q1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=SH3 domain binding protein 4 {ECO:0000313|Ensembl:ENSCPOP00000019005.1};
GN Name=SH3BP4 {ECO:0000313|Ensembl:ENSCPOP00000019005.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000019005.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000019005.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019005.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
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DR EMBL; AAKN02019296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003474628.1; XM_003474580.3.
DR AlphaFoldDB; H0W7Q1; -.
DR STRING; 10141.ENSCPOP00000019005; -.
DR Ensembl; ENSCPOT00000024011.2; ENSCPOP00000019005.1; ENSCPOG00000023889.2.
DR GeneID; 100730563; -.
DR KEGG; cpoc:100730563; -.
DR CTD; 23677; -.
DR VEuPathDB; HostDB:ENSCPOG00000023889; -.
DR eggNOG; ENOG502QTUW; Eukaryota.
DR GeneTree; ENSGT00390000013151; -.
DR HOGENOM; CLU_013080_2_0_1; -.
DR InParanoid; H0W7Q1; -.
DR OMA; HRIRANN; -.
DR OrthoDB; 4019548at2759; -.
DR TreeFam; TF105572; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000023889; Expressed in adult mammalian kidney and 12 other cell types or tissues.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR CDD; cd11757; SH3_SH3BP4; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035456; SH3BP4_SH3.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 55..114
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 317..454
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 655..725
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 964 AA; 107278 MW; 5078ED8E9B5846B0 CRC64;
MAAQRIRAAN SSGLPRCKSE GTLIDLSEGF SETSFNDVKV PSPSALLTDN PTPFGNAKEV
IAIKDYCPTN FTTLKFSKGD HLYVLDASGG EWWYAHNTTE MGYIPSSYVQ PLNYRNSTLS
DSGMIDNLPD SPDEVAKELD LLGGWTDDQK ESGKAYSNNP FWSGVQTNPF LNGNVPVGAG
LDELNPRSTV DLLLFDTGTS SFTESSSATT NSTGNIFDEL PATNGLHGEL PVRRDNPFFR
SKRSYSLSEL SVLQAKSDTP ATSSFFTGLK SPAPEQFQSR EDFRTAWLNH RKLARSCHDL
DLLGQSPGWG QTQAVETNIM CKLDSSGGAV QLPDTNISIH VPEGHVAPGE TQQISMKALL
DPPLELNSDK SSSISPVLEV KLSNLEVNTF LILEMKVSAE VKSDVFSRST VGLQCLRSDV
KEGPYVPIPL SYSYGDTVQV QLDSLEPCMY LAVVAHGPSI IYPSTVWDFI NKKVTVGLYG
PKHIHPSFKT VVTIFGHDCA PKTLLVSEVT RQAPSPAPVA LQLWGKHQFI LARPQDLKVC
MFSNMTNYEV KASEQAKVVR GFQMKLGKVS RLIFPIASQN PSELSDFTLR VQLKDEQEAI
LTQFCVQTPQ PPPKSAIKPS GQRRFLKKNE VGKIILSPFA TTTTRYPTFQ DRPVSSLKFG
KLLKTVVRQN KNQYLLEYKK GDVVALLSEE RIRLRGQLWT KEWYIGYCQG KVGLVHAKNV
LVVGKARPNL CPGPELSTSV LLEQMLRPCK FLTYIYASVR TLLMENVSSW RAFADALGYG
GLPLTSFCRA ELDSEPERVA SVLEKLKEDC NNPDHKDRKS FQKELVMALL KMDCQGLVVR
LIQDFVLLTT AVEVAQRWRE LAEKLAKVSK QQMDAYESPH RDRNGVVDSE AMWKPAYDFL
LTWSHQVGDS YRDVIQELHL GLDRMKSPIT KRWKHLTGTL ILVNSLDVLR AAAFSPMDHD
DFVI
//
