GenomeNet

Database: UniProt
Entry: H0W9F6_CAVPO
LinkDB: H0W9F6_CAVPO
Original site: H0W9F6_CAVPO 
ID   H0W9F6_CAVPO            Unreviewed;      2663 AA.
AC   H0W9F6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSCPOP00000019615};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSCPOP00000019615};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000019615};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000019615}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019615};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000019615}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019615};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AAKN02021497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000019615; -.
DR   Ensembl; ENSCPOT00000014249; ENSCPOP00000019615; ENSCPOG00000014107.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000157078; -.
DR   InParanoid; H0W9F6; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014107; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2193   2218       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2230   2248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2260   2280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2316   2341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2361   2383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2490   2513       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2628   2648       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2663 AA;  302350 MW;  6FCF57F886F00786 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQSKQD KEKIADVVLL QKLQHAAQME RKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASSYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDTPDP KAAGAGAQGR VGRRNAGEQI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDVDEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE
     LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRRNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK
     NSDILIRTEL RPVKEMAQSH EYLSIEYSEE EVWLMWTDKN NERHEKSVRQ LAQEARAGNA
     HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
     MLHVHVDRDP QELVTPVKFA RLWTEIPTVI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY
     LNNVVSEAVP FANEEKNMLT YEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA
     MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGAPN LPVSAGAPEP LDRSKFENNE
     AIVVMETKLK ILDILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT
     ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRTFLRVLI HLTMHDYAPL VSGALQLLFK
     HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSGKGEEGE
     AATAKDKKEG PADEEATGEK GSENYQIVKG ILERLNKMCG VGEQMRKKQQ RLLKNMDAHK
     VMLDLLQIPY DKGDAKMLEI LRYTHQFLQK FCAGNPGNQA LLHKHLHLFL TPGLLEAETM
     QHIFLNNYQL CSEVGEPVLQ HFVHLLATHG RHVQYLDFLH TVIKAEGKYV KKCQDMIMTE
     LTNAGDDVVV FYNDKASLAH LLEMMKAARD GVEDHSPLMY HISLVDLLAA CAEGKNVYTE
     IKCTSLLPLE DVVSVVTHED CITEVKMAYV NFVNHCYVDT EVEMKEIYTS NHIWTLFESF
     TLDMARVCSR REKRLPDPAL EKYVLTVVLD TINAFFSSPF SENSTSLQMH QTIVVQLLQS
     TMRLLECPWL QQQHKGSVEV CIRTLAMVAK GRAISLPMDL DAHISSLLSS GASCAAAAQR
     NAASYKTATR TFPRVTPTAN QWDYKNIIEK LQDIITALEE RLKPLVQAEL SVLVDVLHWP
     ELLFLEGSEA HQRCESGGFL SKLIQHTKDL MESEEKLCVK VLRTLQQMLL KKNKYGERGN
     QLRKMLLQNY LQNRKSSSRG DLPDPMGTGL DQDWSVIGAT QCRLDKEGAT KLVCDLITST
     KNEKIFQESI GLAIRLLDGG NTETQKSFYN LMTSDKKSEC FFKVLHDRMK RAQQETKSTV
     AVNMNDLGGQ PREDREPANP AAKGRVASFS MPGSPSGFSL GPSLRGRHEM SERVQSNEMG
     SSVLIMQPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV CETLQFLDIM CGSTTGGLGL
     LGLYINEDNV GLITQTLETL TEYCQGPCHE NQTCIVTHES NGIDIITALI LNDISPLCKY
     RMDLVLQLKD NASKLLLALM ESRHDSENAE RILISLRPQE LVDVIKKAYV QEEERENSEV
     SPREVGHNIY ILALQVGARA PPLPEAPPLR RPRPMPAPPQ LSLNNKQLSQ MLKSSVPAQE
     EEEDPLAYYE NHTSQIEIVR QDRSMEQIVF PVPAICQFLT EETKHRLFTT TEQDEQGSKV
     SDFFDQSSFL HNEMEWQRKL RSMPLIYWFS RRMTLWGSIS FNLAVFINII IAFFYPYVEG
     ASTGVLGSPL ISLLFWILIC FSIAALFTKR YSIRPLIVAL LLRSIYYLGI GPTLNILGTL
     NLTNKIVFVV SFVGNRGTFI RGYKAMVMDM EFLYHVGYIL TSVLGLFAHE LFYSILLFDL
     IYREETLFNV IKSVTRNGRS ILLTALLALI LVYLFSIVGF LFLKDDFILE VDRLPGNHSR
     ASPLGVPHGA ATFVGTCSGD KLDCVAEVAV PEVPEEDEAA DSMERACDTL LMCIVTVMNH
     GLRNGGGVGD ILRKPSKDES LFPARVVYDL LFFFIVIIIV LNLIFGVIID TFADLRSEKQ
     KKEEILKTTC FICGLERDKF DNKTVSFEEH IKLEHNMWSY LHFIVLVRVK NKTDYTGPES
     YVAQMIKNKN LDWFPRMRAM SLVSSEGEGE QNEIRILQDK LGSTMKLVSH LTAQLNELKE
     QMTEQRKRRQ RLGFVDVQNC MSR
//
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