ID H0WB65_CAVPO Unreviewed; 1884 AA.
AC H0WB65;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=PATJ crumbs cell polarity complex component {ECO:0000313|Ensembl:ENSCPOP00000020231.2};
GN Name=PATJ {ECO:0000313|Ensembl:ENSCPOP00000020231.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020231.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000020231.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020231.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02005164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02005165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02005166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003479178.1; XM_003479130.3.
DR STRING; 10141.ENSCPOP00000020231; -.
DR Ensembl; ENSCPOT00000019471.2; ENSCPOP00000020231.2; ENSCPOG00000024891.2.
DR GeneID; 100730516; -.
DR KEGG; cpoc:100730516; -.
DR CTD; 10207; -.
DR VEuPathDB; HostDB:ENSCPOG00000024891; -.
DR eggNOG; KOG0708; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000155136; -.
DR HOGENOM; CLU_002378_1_0_1; -.
DR InParanoid; H0WB65; -.
DR OMA; RQIEYIN; -.
DR OrthoDB; 2911488at2759; -.
DR TreeFam; TF330709; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000024891; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 11.
DR Gene3D; 2.30.42.10; -; 11.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR015132; L27_2.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR PANTHER; PTHR19964:SF44; PATJ HOMOLOG; 1.
DR Pfam; PF09045; L27_2; 1.
DR Pfam; PF00595; PDZ; 11.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 11.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 11.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 11.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 5..65
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 135..222
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 252..332
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 371..459
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 556..642
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 690..762
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1062..1154
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1237..1320
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1433..1516
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1529..1611
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1672..1758
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1795..1880
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 514..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1884 AA; 201789 MW; 7C68FD342607111E CRC64;
MPENPATDKL QVLQVLERLR AKLQDKGDTS QHDTLSTFCD VLQSPLFTQI LTLQKSLRQL
KGQLSHSPSA IPANFDFSRK GLLVFTEGTT ANGQAPRPAD ACVAVPGPGP WALQLGSDSF
NATVERLAQG RQVEYISIER PPTGGLGFSV VALRNQRLGE VDIFVKEVHP GSVAERDQRL
KENDQILAIN HTALDQSVSH QQAVALLQRS TGPLHLVVAR EPVLASSGCP GSPPGLAPLA
APDVVRWGHM EEVELINDGS GLGFGIVGGK SSGVVVRTIV PGGLADRDGR LHTGDHILRI
GGTDVQGLSS EQVAQVLRTC GSMVRMLVAR DPAGGIIVKP PTPTTSPVAL PAVLTSRSPA
SDSSSLFETH NVELVKQDGQ SLGIRIVGYV GTSHTGEPAG IYVKSIVPGS AAQHSGQIRV
DDQIVAVDGV DIQGLASKDV VQVLQASGRV VHLTLLRRKT PAPLPQRPSE TGSVVGPPRS
PALFLAGAVN TETSLDDEEE TRGDLDNYEQ ASICAPGKLE RASESPENEP KSRWEKLLGP
DYEVMVATLD PQIVDDAELQ KYSKLLPIHT LRLGMEVDSF DGHHYISSIV PGGPVDTLNL
LQPEDELLEV NGVQLFGKSR REAVSFLKEV PPPFTLVCCR RLFDDEASVD DEPRTADTSA
PEMQVEQSVD ANTEEDDDGE LALWSPEVKI VELVKDHKGL GFSILDYQDP LDPTRSVIVI
RSLVADGVAE RSGALLPGDR LVSVNEYSLE DASLADAVEV LKAVPPGTVQ LGICKPLVED
EKEGSCQALQ SGSNEDEAGP AGATGDVELP LLLEAPQGFR DEPYLREELV DEPFLDLGKT
FRSQQNEIND SPEAWEMQEF LSPALQDLGE EQEMLVDEEY ALYQHRLQAL ELRPASSLQD
ATPTPTCQEL HLGAQWLSDE CPGGAESPDA RSLRSVYSTD VQYMMEERFG IDPLSVPSDA
SGPHGTFDDP EHLGSSGESS LDLGMTIPGA DPGQSRLLDL PTGAQRREHD LPLYQLARPR
EATQPSEAWP SRHAADAREL PEREEGEGEE TPSFSHWGPP RIVEIFREPS VSLGISIVGG
QMVIKRLKNG EELKGIFIKQ VLEDSPAGRT NALKTGDKIL EVSGVDLQNA SHQEAVEAIK
NAGNPVVFVV QSLSSIPRVL PSPHNKGSKV ANAPDQDTQE KEEKRRGAAP PPMKLPPPYQ
DPAVEAEEEE EEKEPARQDQ DEKIRQRYAD LPGELHIIEL EKDRQGLGLS LAGNKDRSLM
SIFVVGIQPG SPAAVDGRMR VGDELLEINN QILYGRSHQN ASAIIKTAPR RVKLVFIRNE
GAVQQMAVPP LPCSSPTSTE DTSSPEPVSS EDDGGLEASN EPLPESQHSK PNTSERKEQD
HSPEASLASQ EDPSAPALPC HATEADITDY GDPQAPLSVD PATCPIIPGQ EMIIEISKGR
SGLGLSIVGG RDTPLEAIVI HEVYEEGAAA RDGRLWAGDQ ILEVNGVDLR GCSHEEAITA
LRQTPARVQL VVFRDTAQYR DEDSLEVFTV DLHKKAGRGL GLSIVGKRTG NGVFISAIVK
GGAAELDGRL TQGDQILAVN GEDMRSASQE TVATILKCAQ GLVQLEIGRL RASAWTSSRK
TSRHSQEDPR GAHGSCPTAL APVLAGLQNL VGARRATGPL ERSPGADAEP RTVEIIREHS
DALGISIAGG KGSPLGDVPV FIAMIQANGV AARTRRLKVG DRIVSINGQP LDGRSHADAV
ALLKNAFGRI VLQVVADTNI GAIATQLETM STGQHPSSPG TDHPSEDAEI PPAKMITLER
GSEGLGFSIV GGYGSPHGDL PVYVKTVSAK GAAAHDGRLK RGDQILAVNG ESLEGVTHEQ
AVAILQHQRG TITLAVLPRD PSCC
//
