ID H0WD87_CAVPO Unreviewed; 493 AA.
AC H0WD87;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Acid sensing ion channel subunit 2 {ECO:0000313|Ensembl:ENSCPOP00000020959.2};
GN Name=ASIC2 {ECO:0000313|Ensembl:ENSCPOP00000020959.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020959.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000020959.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020959.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAKN02033127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02033136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013007732.1; XM_013152278.1.
DR AlphaFoldDB; H0WD87; -.
DR STRING; 10141.ENSCPOP00000020959; -.
DR Ensembl; ENSCPOT00000024978.2; ENSCPOP00000020959.2; ENSCPOG00000025132.2.
DR GeneID; 100717745; -.
DR KEGG; cpoc:100717745; -.
DR VEuPathDB; HostDB:ENSCPOG00000025132; -.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000154991; -.
DR HOGENOM; CLU_020415_1_3_1; -.
DR InParanoid; H0WD87; -.
DR OrthoDB; 3415680at2759; -.
DR TreeFam; TF330663; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000025132; Expressed in hypothalamus and 8 other cell types or tissues.
DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:Ensembl.
DR GO; GO:0050974; P:detection of mechanical stimulus involved in sensory perception; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0007602; P:phototransduction; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0035418; P:protein localization to synapse; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0003026; P:regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; IEA:Ensembl.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:Ensembl.
DR GO; GO:0010447; P:response to acidic pH; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
SQ SEQUENCE 493 AA; 55693 MW; B7D7E3D3CF2EE51E CRC64;
MSRSRGAGLP AAALSGPGRF RMAREVAAAG QPGGDRGCER ALQRPGVARR GRPSLSRAKL
HGLRHMCAGR TAAGGSFQRR ALWVLAFCTS LGLLLSWSSN RLLYWLSFPS HTRVHREWSR
QLPFPAVTVC NNNPLRFPRL SKGDLYYAGH WLGLLLPNRT ARPLVSELLR GDEPRRQWFR
KLADFRLFLP PRHFEGISAA FMDRLGHQLE DMLLSCKYRG ELCGPHNFSS VFTKYGKCYM
FNSGEDGKPL LTTVKGGTGN GLEIMLDIQQ DEYLPIWGET EETTFEAGVK VQIHSQSEPP
FIQELGFGVA PGFQTFVATQ EQRLTYLPPP WGECRSSEMG LDFFPVYSIT ACRIDCETRY
IVENCNCRMV HMPGDAPFCT PEQHKECAEP ALGLLAEKDS NYCLCRTPCN LTRYNKELSM
VKIPSKTSAK YLEKKFNKSE KYISENILVL DIFFEALNYE TIEQKKAYEV AALLGKSHCY
TNFHISEGMG RRE
//
