ID H0WDA0_CAVPO Unreviewed; 394 AA.
AC H0WDA0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Cytohesin 4 {ECO:0000313|Ensembl:ENSCPOP00000020972.2};
GN Name=CYTH4 {ECO:0000313|Ensembl:ENSCPOP00000020972.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020972.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000020972.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020972.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02031240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003470514.1; XM_003470466.3.
DR AlphaFoldDB; H0WDA0; -.
DR STRING; 10141.ENSCPOP00000020972; -.
DR Ensembl; ENSCPOT00000025902.2; ENSCPOP00000020972.2; ENSCPOG00000027457.2.
DR GeneID; 100720523; -.
DR KEGG; cpoc:100720523; -.
DR CTD; 27128; -.
DR VEuPathDB; HostDB:ENSCPOG00000027457; -.
DR eggNOG; KOG0930; Eukaryota.
DR GeneTree; ENSGT00940000160865; -.
DR HOGENOM; CLU_032820_3_0_1; -.
DR InParanoid; H0WDA0; -.
DR OMA; MDLCRPE; -.
DR OrthoDB; 204547at2759; -.
DR TreeFam; TF352091; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000027457; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF323; CYTOHESIN-4; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 54..241
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 259..375
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 19..46
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 394 AA; 45552 MW; E1E8CE550D4B4E56 CRC64;
MDLCRPESAE LSSEDAEELQ RIKWHRKQLL EDIQKLKDEI SEVFAQIDCF EGSEDSRMAQ
KDKELCIGRK KFNMDPVKGI QYLTEHKLLK PSAQDIAQFL YKGEGLNKTA IGNYLGERDP
LNLEVLQAFV DCHEFANLNL VQALRQFLWS FRLPGEAQKI DRMMETFAAR YCLCNPGVFQ
STDTCYVLSF AVIMLNTSLH NPNVRDRPPF ERFVSMNRGI NGGGDLPEEQ LRNLFDSIKS
EPFSIPEDDG SDLTYTFFNP DREGWLLKLG GRVKTWKRRW FILTDNCLYY FEFTTDKEPR
GIIPLENLSV QKVDDPKKPF CLELYNPRCR GQRIKACKTD GDGRVVEGKH ESYRISAASA
EERDQWIQAI RASITRVPFY DLVSARKQKI ASKQ
//
