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Database: UniProt
Entry: H0WDH7_CAVPO
LinkDB: H0WDH7_CAVPO
Original site: H0WDH7_CAVPO 
ID   H0WDH7_CAVPO            Unreviewed;       372 AA.
AC   H0WDH7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-OCT-2019, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000021050};
GN   Name=ELF3 {ECO:0000313|Ensembl:ENSCPOP00000021050};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000021050};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000021050, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021050,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000021050}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021050};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSCPOP00000027730}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000027730};
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AAKN02017948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003474737.1; XM_003474689.2.
DR   STRING; 10141.ENSCPOP00000021050; -.
DR   Ensembl; ENSCPOT00000022686; ENSCPOP00000021050; ENSCPOG00000022807.
DR   Ensembl; ENSCPOT00000047362; ENSCPOP00000027730; ENSCPOG00000022807.
DR   GeneID; 100724220; -.
DR   CTD; 1999; -.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000158955; -.
DR   InParanoid; H0WDH7; -.
DR   OrthoDB; 837296at2759; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000022807; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0001824; P:blastocyst development; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0060056; P:mammary gland involution; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd08537; SAM_PNT-ESE-1-like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR042693; Elf-3_PNT.
DR   InterPro; IPR033074; Elf3.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF13; PTHR11849:SF13; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN       46    132       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      274    356       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      174    252       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    177    218       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    223    240       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   372 AA;  42043 MW;  A61B4A9F9B6F2142 CRC64;
     MAATCEISNV FSNYFSAMYS SEDPSLASVP PVSTFGADDL VLSLGNPQTS MEGTEKASWL
     GEQPQFWSKA QVLDWISYQV EKNKYDASSI DFSRCDMDGA TLCSCALEEL RLVFGPLGDQ
     LHAQLRDLTF SSSDELSWII ELLEKDSGVA FQEAGSFDQG SPFTQELPEV TEDGWQASPY
     YPTSYGTGTP SPDCSEVSTA GTGTPQSSHS SDCGGSDVDW DSTDSKLFPR DGFPDCKKGE
     PKHGKRKRGR PRKLSKEYWE CLEGKKNKHA PRGTHLWEFI RDILIHPELN EGLMKWENRH
     EGVFKFLRSE AVAQLWGQKK KNSNMTYEKL SRAMRYYYKR EILERVDGRR LVYKFGKNSS
     GWKEEEVVQS RK
//
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